论文题目：Chiral phosphoric acid catalyzed asymmetric arylation of indoles via nucleophilic aromatic substitution: mechanisms and origin of enantioselectivity

作者：Ka Lu，Xiao Feng,Chao-Xian Yan,Fang-Ling Yang, Xing Yang，Pan-Pan Zhou*，Zhaoyong Yang*

期刊名称：Catal Sci Technol

IF：5.721

年份：2020

卷期页：10:2277–2292

Asymmetric arylation of indole via a nucleophilic aromatic substitution reaction can be effectively realized when chiral phosphoric acid serves as a catalyst in the reaction between azobenzene derivative and indole, producing chiral pyrroloindolines with high yields and excellent enantioselectivity. To elaborate on the reaction processes and origin of enantioselectivity, quantum mechanical calculations were carried out. Both global and local reactivity indexes were employed to understand the reactivity of substrates. The calculations show that eight pathways exist that lead to the products. It was found that chiral phosphoric acid interacts with the substrates via dual hydrogen-bonding activation modes, and it can tautomerize itself to realize both proton and electron transfer and thus promote C–C and C–N bond formation. Quantum theory of atoms in molecules and noncovalent interaction analyses were used to illustrate the roles of weak intermolecular interactions. The origin of enantioselectivity was illustrated by analyzing the stability of the complex and transition state.