余利岩   菌种保藏研究室主任   研究员   博士生导师

教育背景及工作经历：

1996/9–1999/7  中国协和医科大学 微生物与生化药学 博士

1993/9–1996/7  中国协和医科大学 微生物与生化药学 硕士

1987/9–1991/7  山东大学 微生物系 学士

2007/9-至今 中国医学科学院医药生物技术研究所 研究员

2002/9-2007/9  中国医学科学院医药生物技术研究所 副研究员

2000/3-2002/7  中国医学科学院医药生物技术研究所 助理研究员

1998/3-2000/3  日本北里研究所微生物资源室 访问学者

1997/7-1998/3  中国医学科学院医药生物技术研究所 新抗生素室 助理研究员

1996/9-1997/7  中国医学科学院医药生物技术研究所 新抗生素室 实习研究员

1991/8-1993/8  安徽阜阳师范学院 化学系 助教

2002/10-2005/1 美国佐治亚州立大学 博士后

主要研究方向：微生物菌种资源、抗感染药物的研发。

专业研究领域：微生物菌种资源分离、分类及多样性和新颖性研究；抗感染药物研发与抗菌药物作用机制与靶标发现；肠道微生物分离与功能研究。

Selected Publications（近5年责任作者论文）

1. Daldispones A and B, two new cyclopentenones from Daldinia sp. CPCC 400770. Gu G, Cai G, Wang Y, Li L, Bai J, Zhang T, Cen S, Zhang D, Yu L*. J Antibiot (Tokyo). 2021 Mar;74(3):215-218.

2. New butyrolactone derivatives from the endophytic Fungus Talaromyces sp. CPCC 400783 of Reynoutria japonica Houtt. Zhang R, He W, Wang Y, Zhao J, Zhou R, Li L, He Y, Cen S, Yu L*. J Antibiot (Tokyo). 2021 Apr;74(4):225-232.

3. Saccharomycomorpha psychra n. g., n. sp., a Novel Member of Glissmonadida (Cercozoa) Isolated from Arctic and Antarctica. Feng JJ, He CY, Jiang SH, Zhang T, Yu LY*. J Eukaryot Microbiol. 2021 Jan 14:e12840.

4. Development of a New Bioprocess for Clean Diosgenin Production through Submerged Fermentation of an Endophytic Fungus. Liu W, Xiang H, Zhang T, Pang X, Su J, Liu H, Ma B, Yu L*. ACS Omega. 2021 Mar 31;6(14):9537-9548.

5. Screening and Selection of a New Medium for Diosgenin Production via Microbial Biocatalysis of Fusarium sp. Liu W, Xiang H, Zhang T, Pang X, Su J, Liu H, Ma B, Yu L*. Pharmaceuticals (Basel). 2021 Apr 21;14(5):390.

6. Microbial Transformation of neo-Clerodane Diterpenoid, Scutebarbatine F, by Streptomyces sp. CPCC 205437. Zhang D, Tao X, Gu G, Wang Y, Zhao W, Zhao W, Ren Y, Dai S, Yu L*. Front Microbiol. 2021 Apr 14;12:662321.

7. Anemarrhena asphodeloides modulates gut microbiota and restores pancreatic function in diabetic rats. Yan D.,Fan P.C.,Sun W.L., Ding Q.Z., Zheng W.,Xiao W.D., Zhang B.W., Zhang T., Zhang T., Shi J.H., Chen X.J., Chen P.R., Zhang J., Hao Y., Sun X.G., Pang X., Dong Y.S*., Xu P*., Yu L.Y*., Ma B.P. *Biomedicine & Pharmacotherapy, 2021, 133:110954.

8. Soil fungal community composition differs significantly among the Antarctic, Arctic, and Tibetan Plateau. Zhang, T.,Wang, N.F., Yu, L.Y. * Extremophiles, 2020, 24: 821-829.

9. Development of a New High-Cell Density Fermentation Strategy for Enhanced Production of a Fungus-Glucosidase in Pichia pastoris. Liu W, Xiang H, Zhang T, Pang X, Su J, Liu H, Ma B and Yu L*.Front. Microbiol, 2020, 11:1988.

10. Ornithinimicrobium cerasi sp. nov., isolated from the fruit of Cerasus pseudocerasus and emended description of the genus Ornithinimicrobium. Fang XM, Du HJ, Bai JL, He WN, Li J, Wang H, Su J, Liu HY, Zhang YQ, Yu LY*. Int J Syst Evol Microbiol. 2020 Mar; 70(3):1691-1697.

11. Fed-batch high-cell-density fermentation strategies for Pichia pastoris growth and production.Liu WC, Inwood S, Gong T, Sharma A, Yu LY*, Zhu P*.Crit Rev Biotechnol. 2019 Mar; 39(2): 258-271. IF=7.054(综述)；

12. Bacterial community pattern along the sediment seafloor of the Arctic fjorden (Kongsfjorden, Svalbard). Fang XM, Zhang T, Li J, Wang NF, Wang Z, Yu LY*. Antonie Van Leeuwenhoek. 2019 Aug;112(8):1121-1136.

13. GKK1032C, a new alkaloid compound from the endophytic fungus Penicillium sp. CPCC 400817 with activity against methicillin-resistant S. aureus. Qi X, Li X, Zhao J, He N, Li Y, Zhang T, Wang S, Yu L*, Xie Y*. J Antibiot (Tokyo). 2019 Apr;72(4):237-240.

14. Design, synthesis, and bioevaluation of a novel class of (E)-4-oxo-crotonamide derivatives as potent antituberculosis agents. Ren J, Xu J, Zhang G, Xu C, Zhao L, You X, Wang Y, Lu Y, Yu L*, Wang J*. Bioorg Med Chem Lett. 2019 Feb 15;29(4):539-543.

15. Isolation of endophytic fungi from Dioscorea zingiberensis C. H. Wrightand application for diosgenin production by solidstate fermentation. Haibo Xiang，Tao Zhang，Xu Pang，Yuzhen Wei ，Hongyu Liu， Yuqin Zhang，Baiping Ma，Liyan Yu*.Appl Microbiol Biotechnol. 2018 Jul; 102(13):5519-5532.

16. Roseomonas globiformis sp. nov., an airborne bacteria isolated from an urban area of Beijing. Fang XM, Bai JL, Zhang DW, Su J, Zhao LL, Liu HY, Zhang YQ, Yu LY*. Int J Syst Evol Microbiol. 2018 Oct;68(10):3301-3306

17. Glycomyces paridis sp. nov., isolated from the medicinal plant Paris polyphylla. Fang XM, Bai JL, Su J, Zhao LL, Liu HY, Ma BP, Zhang YQ, Yu LY*. Int J Syst Evol Microbiol. 2018 May;68(5):1578-1583.

18. Structural Variation in the Bacterial Community Associated with Airborne Particulate Matter in Beijing, China, during Hazy and Nonhazy Days. Yan D, Zhang T, Su J, Zhao LL, Wang H, Fang XM, Zhang YQ, Liu HY, Yu LY*.Appl Environ Microbiol. 2018 Apr 16;84(9). pii: e00004-18.

19. Peniazaphilin A, a new azaphilone derivative produced by Penicillium sp. CPCC 400786. Zhang D, Zhao J, Wang X, Zhao L, Liu H, Wei Y, You X, Cen S, Yu L*. J Antibiot (Tokyo). 2018 Oct;71(10):905-907.

20. Griseofulvin Derivative and Indole Alkaloids from Penicillium griseofulvum CPCC 400528. Zhang D, Zhao L, Wang L, Fang X, Zhao J, Wang X, Li L, Liu H, Wei Y, You X, Cen S, Yu L*. J Nat Prod. 2017 Feb 24;80(2):371-376.

21. Metabolites from the Plant Endophytic Fungus Aspergillus sp. CPCC 400735 and Their Anti-HIV Activities. Pang X, Zhao JY, Fang XM, Zhang T, Zhang DW, Liu HY, Su J, Cen S, Yu LY*. J Nat Prod. 2017 Oct 27;80(10):2595-2601.

22. Ornithinimicrobium flavum sp. nov., isolated from the leaf of Paris polyphylla. Fang XM, Yan D, Bai JL, Su J, Liu HY, Ma BP, Zhang YQ, Yu LY*.Int J Syst Evol Microbiol. 2017 Nov;67(11):4541-4545.

23. A novel protein kinase inhibitor IMB-YH-8 with anti-tuberculosis activity. Sci Rep. Xu J, Wang JX, Zhou JM, Xu CL, Huang B, Xing Y, Wang B, Luo R, Wang YC, You XF, Lu Y, Yu LY*. 2017 Jul 11;7(1):5093. doi: 10.1038/s41598-017-04108-7

24. Paenibacillus eucommiae sp. nov., isolated from a traditional Chinese medicinal herbal plant, Eucommia ulmoides Oliver. Fang XM, Su J, Wang H, Zhang T, Zhao LL, Liu HY, Ma BP, Zhang YQ, Yu LY*. Int J Syst Evol Microbiol. 2017 Apr;67(4):993-997.

25. Surfactin derivatives from Micromonospora sp. CPCC 202787 and their anti-HIV activities. Pang X, Zhao J, Fang X, Liu H, Zhang Y, Cen S, Yu L*. J Antibiot (Tokyo). 2017 Jan;70(1):105-108.

26. Diversity and distribution of cultured endolichenic fungi in the Ny-Ålesund Region, Svalbard (High Arctic). Zhang T, Wei XL, Wei YZ, Liu HY, Yu LY*. Extremophiles. 2016 Jul; 20(4):461-70.

27. Diversity and Composition of Airborne Fungal Community Associated with Particulate Matters in Beijing during Haze and Non-haze Days. Yan D, Zhang T, Su J, Zhao LL, Wang H, Fang XM, Zhang YQ, Liu HY, Yu LY*. Front Microbiol. 2016 Apr 14; 7:487.

28. Soil pH is a Key Determinant of Soil Fungal Community Composition in the Ny-Ålesund Region, Svalbard (High Arctic). Zhang T, Wang NF, Liu HY, Zhang YQ, Yu LY*.Front Microbiol. 2016 Feb 26;7:227.

29. Diversity and Distribution of Aquatic Fungal Communities in the Ny-Ålesund Region, Svalbard (High Arctic): Aquatic Fungi in the Arctic. Zhang T, Wang NF, Zhang YQ, Liu HY, Yu LY*. Microb Ecol. 2016 Apr;71(3):543-54.

30. Periconiasin G, a new cytochalasan with unprecedented 7/6/5 tricyclic ring system from the endophytic fungus Periconia sp.，Dewu Zhang, Xiaoyu Tao, Jimei Liu, Ridao Chen, Min Zhang, Li Li, Xiaomei Fang, Yu LY*, Jungui Dai* .Tetrahedron Letters, 2016, 57(7) :796-799

31. A new polyketide synthase nonribosomal peptide synthetase hybrid metabolite from plant endophytic fungus Periconia sp. De-Wu Zhang, Xiao-Yu Tao, Ji-Mei Liu, Ri-Dao Chen, Min Zhang, Xiao-Mei Fang, Li-Yan Yu,*, Jun-Gui Dai*. Chinese Chemical Letters, 2016, 47(5):640-642

32. Diversity and distribution of fungal communities in the marine sediments of Kongsfjorden, Svalbard (High Arctic). Zhang T, Wang NF, Zhang YQ, Liu HY, Yu LY*. Sci Rep. 2015 Oct 23;5:14524.

33. Diversity and distribution of lichen-associated fungi in the Ny-Ålesund Region (Svalbard, High Arctic) as revealed by 454 pyrosequencing. Zhang T, Wei XL, Zhang YQ, Liu HY, Yu LY*.Sci Rep. 2015 Oct 14;5:14850.

专利：（第一发明人专利）

1. 以SecA动力泵为靶点的抗革兰氏阴性细菌药物筛选模型及用途，ZL 200810097816.5，授权日期：2013-07-31

2. 一种筛选PknB抑制剂的反应体系及其筛选方法，ZL 201110138454.1，授权日期：2014-04-30

3. 灰黄青霉、由其产生的抗菌活性化合物及应用，ZL 201210034285.1，授权日期：2014-11-26

4. 两株游动放线菌及其在抗细菌中的应用，ZL201110175099.5，授权日期：2015-10-07

5. β-羰基丙烯酰胺类化合物、其制备方法及应用，ZL 201510369945.5，授权日期：2018-04-27

6. 4-氧代-2-丁烯酰胺衍生物在制备抑菌剂中的应用，ZL 201710072890.0 ，授权日期：2019-12-31

7. 一株曲霉菌及其应用，ZL 201610424586.3，授权日期：2019-07-12

8. 聚酮在抑制HIV中的应用，ZL 201610425273.X ，授权日期：2019-07-12

9. 聚酮在抑制流感病毒中的应用，ZL 201710077812.X ，授权日期：2019-12-31

10. 生物催化制备薯蓣皂苷元的方法及其所用菌剂，ZL 201710220575.8，授权日期：2020-12-29

11. 一种产生抗HIV活性物质的链霉菌及其应用，ZL 201510221567.6，授权日期：2020-10-27

12. 一种糖基水解酶及其相关生物材料与应用，201811113393.1，申请日期：2018-09-25

13. 来源于篮状菌的抗流感病毒化合物及其制备方法与应用，202010697042.0，申请日期：2020-07-20

14. 用于制备薯蓣皂苷元的菌剂及其应用，202011385285.7，申请日期：2017-04-05

15. 利用生物酶制备薯蓣皂苷元的方法及其所用生物材料，201811113218.2，申请日期：2018-09-25

16. 一株曲霉菌的用途及由该曲霉菌制备的化合物及其用途，201910609383.5，申请日期：2016-06-15

17. 液态发酵盾叶薯蓣制备薯蓣皂苷元的方法，202011245284.2 ，申请日期：2020-11-10

专著：

1. 《微生物菌种资源收集、整理、保藏技术规程汇编》.副主编，2011，中国农业科技出版社

2. 《微生物菌种资源描述规范汇编》.副主编，2009年，中国农业科技出版社

3. 《药物微生物学》·主译·2007.10，化学出版社

4. 《中国药用微生物菌种目录》，副主编，2006年，方正出版社

5. 《药物筛选方法与实践》，编写人员，2007年，化学出版社

6. 《微生物制药》，编写人员，2002年，化学工业出版社

获奖情况：

教育部"新世纪优秀人才支持计划"；协和学者特聘教授

学术任职：现任酶工程与发酵工程专业委员会主任委员，微生物资源专业委员会副主任，中国医学科学院/北京协和医学院第七届学术委员会委员以及《微生物学通报》、《中国抗生素杂志》、《中国医药生物技术》杂志编委等。

联系电话：010-63187118

电子邮箱：yly@cpcc.ac.cn（Liyanyu@imb.pumc.edu.cn）