刘明亮   合成室   研究员   硕士生导师

教育背景及工作经历：

2011/09 -至今  中国医学科学院医药生物技术研究所 研究员

2004/09 -2011/08  中国医学科学院医药生物技术研究所 副研究员

1996/08 -2004/08  中国医学科学院医药生物技术研究所 助理研究员

1994/07 -1996/07  北京市密云区第二中学 教师

1984/07-1994/06  青海省西宁市第十三中学 教师

2000/09 -2003/07 北京协和医学院 微生物与生化药学 硕士

1980/09 -1984/07 陕西师范大学化学系 化学 学士

主要研究方向：抗感染及抗肿瘤新化合物的筛选

专业研究领域：通过对抗感染（抗菌、抗结核、抗病毒）及抗肿瘤新化合物的设计、合成及构-效关系研究，发现若干有苗头的化合物。2个抗感染1.1类候选物分别获得II 期临床试验批件和完成初步临床前研究。

代表性论文（近3年）：

1. Apeng Wang, Shijie Xu, Yun Chai, Guimin Xia, Bin Wang, Kai Lv, Chao Ma, Dan Wang, Aoyu Wang, Xiaoyu Qin, Mingliang Liu, Yu Lu. Design, synthesis and biological activity of N-(amino)piperazine-containing benzothiazinones against Mycobacterium tuberculosis. Eur. J. Med. Chem., 2021, 218：113398

2. Zhanying Hu, Haiqun Ban, Haiyan Zheng, Mingliang Liu, Jinhong Chang, Jutao Guo. Protein phosphatase 1 catalyzes HBV core protein dephosphorylation and is co-packaged with viral pregenomic RNA into nucleocapsids. PLoS Pathog, 2020,16(7): e1008669

3. Apeng Wang, Yu Lu, Kai Lv, Chao Ma, Shijie Xu, Bin Wang, Yun Chai, Guimin Xia, Mingliang Liu. Design, synthesis and antimycobacterial activity of new benzothiazinones inspired by rifampicin / rifapentine. Bioorg. Chem., 2020, 94: 103363

4. Shaochen Guo, Lei Fu, Bin Wang, Xi Chen, Jiaojie Zhao, Mingliang Liu, Lu, Y. In vitro and in vivo antimicrobial activities of a novel piperazine-containing benzothiazinones candidate TZY-5-84 against Mycobacterium tuberculosis. Biopha, 2020，131：110777

5. Apeng Wang, Chao Ma, Yun Chai, Xiujun Liu, Kai Lv, Lei Fu, Bin Wang, Mingliang Liu, Yu Lu. Identification of benzothiazinones containing 2-benzyl-2,7-diazaspiro[3.5]nonane moieties as new antitubercular agents. Eur. J. Med. Chem., 2020, 200:112409

6. Kai Lv, Wenyan Li, Shuo Wu, Yunhe Geng, Apeng Wang, Lu Yang, Menghao Huang, Kushan Chowdhury, Yuhuan Li, Mingliang Liu. Amino acid prodrugs of NVR3-778: design, synthesis and anti-HBV activity. Bioorg Med Chem Lett, 2020, 30: 127103

7. Linhu Li, Apeng Wang, Bin Wang, Mingliang Liu, Kai Lv, Zeyu Tao, Chao Ma, Xican Ma, Bing Han, Aoyu Wang, Yu Lu. N-(2-Phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamides containing various amine moieties: design, synthesis and antitubercular activity. Chin Chem Lett, 2020, 31: 409–412

8. Kai Lv, Shuo Wu, Wenyan Li, Yunhe Geng, Meng Wu, Jinming Zhou, Yuhuan Li, Qiang Gao, Mingliang Liu. Design, synthesis and anti-HBV activity of NVR3-778 derivatives. Bioorg.Chem., 2020, 94: 103363

9. Hua Jin, Ting Zhu, Xiange Huang, Mo Sun, Hegen Li, Xinyuan Zhu, Mingliang Liu, Yibin Xie,Wei Huang, Deyue Yan. ROS-responsive nanoparticles based on amphiphilic hyperbranched polyphosphoester for drug delivery: Light-triggered size-reducing and enhanced tumor penetration. Biomaterials. 2019, 211: 68-80.

10. Apeng Wang, Kai Lv, Zeyu Tao, Jian Gu, Lei Fu, Mingliang Liu, Baojie Wand, Scott G. Franzblau, Chao Ma, Xican Ma, Bing Han, Aoyu Wang, Shijie Xu, Yu Lu. Identification of Benzothiazinones Containing an Oxime Functional Moiety as New Anti-tuberculosis Agents. Eur. J. Med. Chem., 2019, 181: 111595

11. Apeng Wang, Kai Lv, Linhu Li, Hongtao Liu, Zeyu Tao, Bin Wang, Mingliang Liu, Chao Ma, Xican Ma, Bing Han, Yu Lu. Design, synthesis and biological activity of N-(2-phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamides as new antitubercular agents. Eur. J. Med. Chem., 2019,175: 715-725

12. Kai Lv, Apeng Wang, Zeyu Tao, Hongtao Liu, Lei Fu, Bin Wang, Chao Ma, Hongjian Wang, Xican Ma, Bing Han, Auyu Wang, Kai Zhang, Mingliang Liu, Yu Lu. hERG optimizations of IMB1603, discovery of alternative Benzothiazinone candidates as new antitubercular agents. Eur. J. Med. Chem., 2019,179: 208-217

13. Apeng Wang, Shuo Wu, Zeyu Tao, Xiaoning Li, Kai Lv, Chao Ma, Yuhuan Li, Linhu Li, Mingliang Liu. Design, synthesis and anti-HBV activity of new bis(L-amino acid) ester tenofovir prodrugs. ACS Med. Chem. Lett., 2019, 10: 991-995

14. Meng Wu, Yongli Xie, Xiangling Cui, Chenchao Huang, Rongyu Zhang, Yang He, Xiaoyu Li, Mingliang Liu, Shan Cen, Jinming Zhou. Rational drug design for androgen receptor and glucocorticoids receptor dual antagonist. Eur. J. Med. Chem., 2019, 166：232-242

15. Hongjian Wang, Apeng Wang, Jian Gu, Fu Lei, Yun Chai, Kai Lv, Chao Ma, Zeyu Tao, Bin Wang, Mingliang Liu, Huiyuan Guo, Yu Lu. Design, synthesis and antimycobacterial activity of less lipophilic imidazo[1,2-a]pyridine-3-carboxamide derivatives as new antitubercular agents. Eur. J. Med. Chem., 2019, 165：11-17

16. Hongjian Wang, Kai Lv, Apeng Wang, Bin Wang, Zeyu Tao, Mingliang Liu, Huiyuan Guo, Yu Lu. Design, synthesis and antimycobacterial activity of novel nitrobenzamide derivatives. Chin. Chem. Lett., 2019, 30：413-416

17. Apeng Wang, Hongjian Wang, Yunhe Geng, Bin Wang, Kai Lv, Mingliang Liu, Zeyu Tao, Huiyuan Guo, Yu Lu. Design, synthesis and antimycobacterial activity of Q203 derivatives containing alkaline fused ring moieties. Bioorg. Med. Chem., 2019, 27：813-821

18. Yangguang Liu, Meng Wu, Tianqi Wang, Yongli Xie, Xiangling Cui, Liujun He, Yang He, Xiaoyu Li, Mingliang Liu, Laixing Hu, Shan Cen and Jinming Zhou. Structural Based Screening of Antiandrogen Targeting Activation Function-2 Binding Site. Front Pharmacol, 2018, 9:1419

19. Qing-Cheng Ren, Chuan Gao, Zhi Xu, Lian-Shun Feng, Ming-liang Liu, Xiang Wu, Feng Zhao. Bis-coumarin Derivatives and Their Biological Activities. Curr. Top Med. Chem., 2018, 18(2): 101-113

20. Dan Jiang, Gang-Qiang Wang, Xiaofeng Liu, Zhenbin Zhang, Lian-Shun Feng, Ming-Liang Liu. Isatin Derivatives with Potential Antitubercular Activities. J. Heterocyclic Chem., 2018, 55, 1263-1279

21. Guo-Cheng Huang, Yan Xu, Zhi Xu, Zao-Sheng Lv, Jun Zhang, Hui-Yuan Guo, Yuan-Qiang Hu, Ming-Liang Liu, Jian-Guo Guan, Lu Yu. Propylene-1H-1,2,3-triazole-4-methylene-tethered Isatin-coumarin Hybrids: Design, Synthesis, and In Vitro Anti-tubercular Evaluation. J. Heterocyclic. Chem., 2018, 55, 830-835

22. Zeyu Tao, Ruiyuan Cao, Yunzheng Yan, Guocheng Huang, Kai Lv, Wei Li, Yunhe Geng, Lei Zhao, Apeng Wang, Qinghao He, Jingjing Yang, Shiyong Fan, Menghao Huang, Huiyuan Guo, Wu Zhong, Mingliang Liu. Design, Synthesis and in vitro Anti-Zika virus evaluation of novel Sinefungin derivatives. Eur. J. Med. Chem., 2018, 157：994-1004.

23. Yang Gao, Lu-Xin Na, Zhi Xu, Lian-Shun Feng, A-Peng Wang, Kai Lv, Hui-yuan Guo, Ming-Liang Liu. Design, Synthesis and Antibacterial Evaluation of 1-[(1R, 2S)-2-Fluorocyclopropyl] ciprofloxacin-1,2,4-triazole-5(4H)-thione Hybrids. Chem Biodiv，2018, e1800261

24. Apeng Wang Guocheng Huang, Bin Wang, Kai Lv, Hongjian Wang, Zeyu Tao, Mingliang Liu, Huiyuan Guo, Yu Lu. Design, synthesis and antimycobacterial activity of 3,5-dinitrobenzamide derivatives containing fused ring moieties. Bioorg. Med. Chem. Lett.，2018, 28: 2945-2948

25. Linhu Li, Kai Lv, Genhua Chen, Apeng Wang, Bin Wang, Mingliang Liu, Huiyuan Guo, Yu Lu. Identification of N-benzyl 3,5-dinitrobenzamides as New Antitubercular Agents. ACS Med. Chem. Lett., 2018, 9:741-745.peng Wang, Wenyan Li, Bin Wang, Kai Lv, Hongjian Wang, Mingliang Liu, Huiyuan Guo, Yu Lu. Design, synthesis and evaluation of nitrofuranyl methyl N-heterocycles derivatives as novel antitubercular agents. Future Med. Chem., 2018, 10 (17): 2059-2068

26. Kai Lv, Zeyu Tao, Qian Liu, Lu Yang, Bin Wang, Shuo Wu, Apeng Wang, Mingliang Liang Liu, Yu Lu. Design, synthesis and antitubercular evaluation of benzothiazinones containing a piperidine moiety. Eur. J. Med. Chem., 2018, 151：1-8

27. Apeng Wang, Yang Yang, Genhua Chen, Bin Wang, Kai Lv, Mingliang Liu, Huiyuan Guo, Yu Lu. Nitrofuranyl Methyl derivatives as novel antitubercular agents. Bioorg. Med. Chem., 2018, 26: 2073-2084. Gui-Fu Zhang, Xiaofeng Liu, Shu Zhang, Baofeng Pan, Ming-Liang Liu. Ciprofloxacin derivatives and their antibacterial activities. Eur. J. Med. Chem., 2018, 146: 599-612.

专利：申请中国发明专利47件（其中授权31件）

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电子邮箱：liumingliang@imb.pumc.edu.cn