国家优秀青年科学基金获得者

彭宗根

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时间:2021-07-07    

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彭宗根   病毒室   研究员   博士生导师

教育背景及工作经历:

曾先后就读于南昌大学生命科学工程系微生物学专业(本科)、福建医科大学病原生物学专业(硕士)和中国协和医科大学微生物与生化药学专业(博士)。毕业后留所工作至今,先后在美国和加拿大做短期访问学者和学习。

主要研究方向: 抗肝炎、抗病毒药物药理学。

专业研究领域:以宿主因子为靶的抗病毒、抗非酒精性脂肪性肝炎药物的研发。

代表性论文:

1. Zou LL, Li JR, Li H, Tan JL, Wang MX, Liu NN, Gao RM, Yan HY, Wang XK, Dong B, Li YH, Peng ZG*. TGF-β isoforms inhibit hepatitis C virus propagation in transforming growth factor beta/SMAD protein signalling pathway dependent and independent manners. J Cell Mol Med. 2021 Apr;25(7):3498-3510.

2. Lv XQ, Zou LL, Tan JL, Li H, Li JR, Liu NN, Dong B, Song DQ, Peng ZG*. Aloperine inhibits hepatitis C virus entry into cells by disturbing internalisation from endocytosis to the membrane fusion process. Eur J Pharmacol.  2020 Sep 15, 883173323.

3. Jiang X#, Tan J#, Wang Y, Chen J, Li J, Jiang Z, Quan Y, Jin J, Li Y, Cen S, Li Y*, Peng Z*, Li Z*. 2-((4-Arylpiperazin-1-yl)methyl)benzonitrile Derivatives as Orally Available Inhibitors of Hepatitis C Virus with a Novel Mechanism of Action. J Med Chem. 2020 Jun 11;63(11):5972-5989.

4. Li H#, Tan JL#, Li JR#, Liu NN, Chen JH, Lv XQ, Zou LL, Dong B, Peng ZG*, Jiang JD*. A proof-of-concept study in HCV-infected Huh7.5 cells for shortening the duration of DAA-based triple treatment regimens. Biomed Pharmacother. 2019 Aug; 116: 108976.

5. Wu ZY#, Li H #, Li JR, Lv XQ, Jiang JD, Peng ZG*. Farnesoid X receptor agonist GW4064 indirectly inhibits HCV entry into cells via down-regulating scavenger receptor class B type I. Eur J Pharmacol, 2019, 15 June, 853: 111-120.

6. Huang MH#, Li H#, Xue R, Li JR, Wang LH, ChengJJ, Wu ZY, Li WJ, Chen JH, Lv XQ, Li Q, Lan P, Zhao LM, Yang YF*, Peng ZG*, Jiang JD*. Up-regulation of glycolipid transfer protein by bicyclol causes spontaneous restriction of hepatitis C virus replication. Acta Pharmaceutica Sinica B. 2019 Jul; 9(4):769-781.

7. Li H, Li JR, Huang MH, Chen JH, Lv XQ, Zou LL, Tan JL, Dong B, Peng ZG*, Jiang JD* . Bicyclol attenuates liver inflammation induced by infection of hepatitis C virus via repressing ROS-mediated activation of MAPKs/NF-κB signaling pathway. Front. Pharmacol. 2018, Dec 19; 9:1438

8.Zhang X#, Lv XQ#, Tang S, Mei L, Li YH, Zhang JP, Jiang JD, Peng ZG*, Song DQ*. Discovery and evolution of aloperine derivatives as a new family of HCV inhibitors with novel mechanism. Eur J Med Chem. 2018 Jan 1;143:1053-1065.

9. Ji XY#, Chen JH#, Zheng GH, Huang MH, Zhang L, Jin J, Yi H, Jiang JD, Peng ZG*, Li ZR*. Design and Synthesis of Cajanine Analogues against Hepatitis C Virus through Down-regulating Host Chondroitin Sulfate N-acetylgalactosaminyltransferase 1. J Med Chem. 2016 Nov 23;59(22):10268-10284

10. Cheng JJ, Li JR, Huang MH, Ma LL, Wu ZY, Jiang CC, Li WJ, Li YH, Han YX, Li H, Chen JH, Wang YX, Song DQ, Peng ZG*, Jiang JD*. CD36 is a co-receptor for hepatitis C virus E1 protein attachment. Sci Rep. 2016 Feb 22;6:21808.

荣誉奖励:

国家万人计划科技创新领军人才,科技部中青年科技创新领军人才,国家自然科学基金委优秀青年基金获得者,教育部新世纪优秀人才,北京市科技新星;国家科学技术进步奖二等奖。

学术任职:

《药学学报》中、英文刊青年编委,《中国医药生物技术》、《病毒学报》等期刊编委,中国医学科学院第七届学术委员会委员

联系电话:010-63166129

电子邮箱: pumcpzg@126.compengzonggen@imb.pumc.edu.cn