庞旭 菌种保藏研究室 副研究员

教育背景及工作经历：

2021.10 –至今 中国医学科学院医药生物技术研究所 副研究员

2020.10 –2021.09 中国医学科学院医药生物技术研究所 助理研究员

2018.10 – 2020.09 军事科学院军事医学研究院 博士后

2016.09 − 2018.08 天津中医药大学 助理研究员

2013.09 − 2016.07 中国医学科学院医药生物技术研究所 博士

2008.09 − 2011.07 军事医学科学院 硕士

2004.09 − 2008.07 南方医科大学 学士

主要研究方向：天然产物化学

专业研究领域：目前主要从事微生物天然产物研究，内容包括：（1）基于特殊生境微生物资源以及沉默基因簇激活策略发掘新颖结构微生物次级代谢产物；（2）以生物活性为导向寻找活性微生物次级代谢产物，并开展特定类别活性成分的系统研究。

代表性论文：

1.Zhao Jianyuan#, Wang Jing #, Pang Xu#, Liu Zhenlong, Li Quanjie, Yi Dongrong, Zhang Yongxin, Fang Xiaomei, Zhang Tao, Zhou Rui, Zhang Tao, Guo Zhe, Liu Wancang, Li Xiaoyu, Liang Chen, Deng Tao, Guo Fei*, Yu Liyan*, Cen Shan*. An anti-influenza A virus microbial metabolite acts by degrading viral endonuclease PA. Nature Communications. 2022, 13(1), 2079.

2.Tao Zhang#*, Guowei Cai#, Xiaoting Rong, Yuquan Wang, KaiKai Gong, Wancang Liu, Lu Wang, Xu Pang*, and Liyan Yu*. A Combination of Genome Mining with an OSMAC Approach Facilitates the Discovery of and Contributions to the Biosynthesis of Melleolides from the Basidiomycete Armillaria tabescens. Journal of Agricultural and Food Chemistry. 2022. doi.org/10.1021/acs.jafc.2c04079.

3.Zhang Tao#, Pang Xu#, Zhao Jianyuan, Guo Zhe, He Wenni, Cai Guowei, Su Jing, Cen Shan, Yu Liyan*. Discovery and Activation of the Cryptic Cluster from Aspergillus sp. CPCC 400735 for Asperphenalenone Biosynthesis. ACS Chemical Biology. 2022, 17(6):1524-1533.

4.Pang Xu#, Wan Lingfei#, Yang Jie, Bai Peiyin, Zhang Jie, Chen Xiao-juan, Yan Xinlong*, Ma Baiping*. Steroidal saponins from Trillium tschonoskii rhizome repress cancer stemness and proliferation of intrahepatic cholangiocarcinoma. Bioorganic Chemistry. 2022, 121:105679.

5.Sun XinGuang#, Pang Xu#, Liang Haizhen#, Zhang Jie, Wang Bei, Li Qi, Wang Jie, Chen Xiaojuan, Guo Baolin, Ma Baiping*. New prenylated flavonoid glycosides derived from Epimedium wushanense by β-glucosidase hydrolysis and their testosterone production-promoting effects. Chinese Journal of Natural Medicines. 2022. 20(9):712-720.

6.Hao Feiran#, Pang Xu#, Xu Kaikun, Wang Meixi, Ma Zengchun, Tan Hongling, Han Lifeng, Chang Cheng, Chen Ming, Huang Zhanwen, Gao Yue*. Anaphylactic rare saponins separated from Panax notoginseng saponin and a proteomic approach to their anaphylactic mechanism. Evidence-Based Complementary and Alternative Medicine. 2022, 2022:7565177.

7.Pang Xu*, Duan Zhiwen, Liu Caiyan, Yu Haiyang, Han Lifeng, Ma Baiping*. N-containing compounds from Hymenocallis littoralis and their cytotoxicity against Hep3B cells. Phytochemistry Letters. 2022, 48:54-56.

8.Wang Chenxi#, Pang Xu#, Zhu Tongtong, Ma Shuhu, Liang Yunfei, Zhang Yi, Lan Xing, Wang Tao*, Han Lifeng*. Rapid discovery of potential ADRs compounds from Injection of total Saponins from Panax Notoginseng using data independent acquisition untargeted metabolomics. Analytical and Bioanalytical Chemistry. 2022, 414:1081-1093.

9.Pang Xu, Wang Mei, Wang Shuangyan, Zhang Jie, Du Yapeng, Zhao Ye, Zheng Xiaohui, Ma Baiping*. Phenolic compounds from the leaves of Crataegus pinnatifida Bge.var. major N. E. Br. and their lipid-lowering effects. Bioorganic & Medicinal Chemistry Letters. 2021, 47:128211.

10.Wang Chenxi, Xing Yanchao, Ding Hui, Wang Ping, Zhang Lihua, Fu Zhifei*, Han Lifeng, Pang Xu*. Multiple components-pharmacokinetic studies on ten bioactive constituents of Peiyuan Tongnao Capsule, using parallel reaction monitoring mode. Biomedical Chromatography. 2021, e5153.

11.Pang Xu#, Zhao Jianyuan#, Wang Yujia, Zheng Wei, Zhang Jie, Chen Xiaojuan, Cen Shan, Yu Liyan, Ma Baiping*. Steroidal glycosides, homoisoflavanones and cinnamic acid derivatives from Polygonatum odoratum and their inhibitory effects against influenza A virus. Fitoterapia. 2020, 246:104689.

12.Yang Yinjun#, Pang Xu#, Wang Bei, Yang Jie, Chen Xiaojuan, Sun Xinguang, Li Qi, Zhang Jie, Guo Baolin, Ma Baiping*. Steroidal saponins from Trillium tschonoskii rhizomes and their cytotoxicity against HepG2 cells. Steroids. 2020, 156:108587.

13.Yin Shuangshuang, Qiu Yuling, Jin Chengyun, Wang Rui, Wu Song, Liu Hongwei, Koo Sangho, Han Lifeng, Zhang Yi, Gao Xiumei, Pang Xu*, Wang Tao*, Yu Haiyang*. 7-deoxynarciclasine shows promising antitumor efficacy by targeting Akt against hepatocellular carcinoma. International Journal of Cancer. 2019. 145(12):3334–3346.

14.Pang Xu#, Wang Liming#, Zhang Youcai, Kang Liping, Yu Heshui, Fan Guanwei*, Han Lifeng*. New anthraquinone and eurotinone analogue from the seeds of Senna obtusifolia and their inhibitory effects on human organic anion transporters 1 and 3. Natural Product Research. 2019, 33(23):3409–3416.

15.Pang Xu, Yin Shuangshuang, Yu Haiyang, Zhang Yi, Wang Tao, Hu Limin, Han Lifeng*. Prenylated flavonoids and dihydrophenanthrenes from the leaves of Epimedium brevicornu and their cytotoxicity against HepG2 cells. Natural Product Research. 2018, 32(19):2253–2259.

16.Pang Xu, Zhao Jianyuan, Yu Haiyang, Yu Liyan, Wang Tao, Zhang Yi, Gao Xiumei, Han Lifeng*. Secoiridoid analogues from the fruits of Ligustrum lucidum and their inhibitory activities against influenza A virus. Bioorganic & Medicinal Chemistry Letters. 2018, 28(9):1516–1519.

17.Pang Xu, Kang Liping, Fang Xiaomei, Yu Heshui, Han Lifeng, Zhao Yang, Zhang Lixia, Yu Liyan, Ma Baiping*. C21 steroid derivatives from the Dai herbal medicine Dai-Bai-Jie, the dried roots of Marsdenia tenacissima, and their screening for anti-HIV activities. Journal of Natural Medicines. 2018, 72(1):166–180.

18.Pang Xu#, Kang Liping#, Fang Xiaomei#, Zhao Yang, Yu Heshui, Han Lifeng, Li Haitao, Zhang Lixia*, Guo Baolin, Yu Liyan, Ma Baiping*. Polyoxypregnane glycosides from the roots of Marsdenia tenacissima and their anti-HIV activities. Planta Medica. 2017, 83:126–134.

19.Pang Xu, Zhao Jianyuan, Fang Xiaomei, Zhang Tao, Zhang Dewu, Liu Hongyu, Su Jing, Cen Shan, Yu Liyan*. Metabolites from the plant endophytic fungus Aspergillus sp. CPCC 400735 and their anti-HIV activities. Journal of Natural Products. 2017, 80(10):2595–2601.

20.Pang Xu, Zhao Jianyuan, Fang Xiaomei, Liu Hongyu, Zhang Yuqin, Cen Shan, Yu Liyan*. Surfactin derivatives from Micromonospora sp. CPCC 202787 and their anti-HIV activities. Journal of Antibiotics. 2017, 1:105–108.

授权专利：

1.一株曲霉菌的用途及由该曲霉菌制备的化合物及其用途（发明人：余利岩，庞旭，岑山，赵建元，张涛，方晓梅，刘红宇，苏静，张德武），专利号ZL 201910609383.5，授权日：2021.11.19

2.一种产生抗HIV活性物质的链霉菌及其应用（发明人：余利岩、庞旭、岑山、马玲、方晓酶、魏玉珍、李晓宇、刘红宇），专利号ZL 201510221567.6，授权日：2020.10.27

3.一种化合物、包含其的决明子提取物及其用途（发明人：韩立峰、庞旭、樊官伟、于海洋、张祎、王涛），专利号ZL 201711420209. 3，授权日：2020.10.13

4.聚酮在抗流感病毒中的应用（发明人：余利岩，岑山，赵建元，庞旭，张涛，方晓梅，张永欣），申请号ZL 201710077812.X 授权日：2019.12.31

一株曲霉菌及其应用（发明人：余利岩、庞旭、岑山、赵建元、张涛、方晓梅、刘红宇、苏静、张德武），专利号ZL 201610424586. 3，授权日：2019.07.12

5.聚酮在抑制HIV中的应用（发明人：余利岩、庞旭、岑山、赵建元、张涛、方晓梅、刘红宇、苏静、张德武），专利号ZL 201610425273.X，授权日：2019.07.12

联系电话：18610675242

电子邮箱：pangxu@imb.pumc.edu.cn；pangxu320@163.com