庞晶   药理室   副研究员   硕士生导师

教育背景及工作经历：

2019.9-至今 中国医学科学院医药生物技术研究所 副研究员

2012.6-2019.8中国医学科学院医药生物技术研究所 助理研究员

2007.9-2012.6中国医学科学院医药生物技术研究所 微生物与生化药学 博士

2003.9-2007.6 中南大学湘雅医学院 药学 学士

其中2014-2015年在美国佐治亚大学开展博士后工作。

主要研究方向：药物代谢动力学、抗感染药物药理

专业研究领域：药物代谢动力学、抗菌药物的PKPD研究、抗菌药物的发现、抗菌药效学和药物作用机制研究

代表性论文：

1. Pang J, Mortuza T, White CA, Muralidhara S, Cummings BS, Bruckner JV. Toxicokinetics of cis- and trans-Permethrin: Influence of Isomer, Maturation, and Sex. Toxicol Sci. 2020 Mar 1;174(1):25-37.

2. Fan T, Guo X, Zeng Q, Wei W, You X, Wang Y, Pang J*, Song D. Synthesis and Structure-Activity Relationship of Palmatine Derivatives as a Novel Class of Antibacterial Agents against Helicobacter pylori.Molecules. 2020 Mar 16;25(6):1352. doi: 10.3390/molecules25061352.

3. He S, Chen HT, Zhao R, Hu XX, Nie TY, Yang XY, Li CR, Lu X, Wang XK, Li X, Lu Y, Li GQ, Pang J*, You XF. Development and validation of a sensitive LC-MS/MS method for the quantitation of IMB-YH-4py5-2H, an antituberculosis candidate, and its application to the pharmacokinetic study. PLoS One. 2020 Feb 19;15(2):e0228797.

4. Wang G*, Pang J*, Hu X, Nie T, Lu X, Li X, Wang X, Lu Y, Yang X, Jiang J, Li C, Xiong YQ, You X. Daphnetin: A Novel Anti-Helicobacter pylori Agent. Int J Mol Sci. 2019 Feb 15;20(4).

5. Pang J, Li CR, Zhao R, Nie TY, Li GQ, Lu X, Hu XX, Wang XK, Yang XY, You XF. Simplified LC-MS/MS method for quantification of IG-105, a novel tubulin ligand, and its application to the pharmacokinetic study in rats at the anticancer effective dose. Pharmazie. 2019 Feb 1;74(2):79-82

6. Pang J, Li GQ, Li CR, Yang XY, Lu X, Hu XX, Zhai QQ, Zhang WX, Jiang JD, You XF. Toxicokinetic study of melamine in the presence and absence of cyanuric acid in rats.J Appl Toxicol. 2013 Jun;33(6):444-50.

7. 庞晶，胡辛欣，王跃明，李聪然，杨信怡，刘宗英，胡来兴，宋丹青，李卓荣，游雪甫，蒋建东，新型抗肿瘤微管抑制剂IG-105 的体外代谢及药物相互作用的研究，药学学报，2017年第6期

8. 庞晶，胡辛欣，李国庆，王秀坤，聂彤颖，卢曦，李雪，杨信怡，李聪然，游雪甫，注射用甲磺酸吉米沙星的体外抗菌活性研究，中国抗生素杂志，2017年第5期。

9. 庞晶，刘尚裕，张伟新，李国庆，杨信怡，李聪然，游雪甫，丹参有效部位的一般药理学和长期毒性研究，中国医药生物技术，2015 第 1 期 。

10. 庞晶，王秀坤，杨信怡，胡辛欣，宋坤改，聂彤颖，卢曦，李雪，李聪然，游雪甫，艾帕培南的小鼠泌尿道上行性感染药效学研究，中国抗生素杂志，2014年第11期。

11. Dong L, Pang J, Wang X, Zhang Y, Li G, Hu X, Yang X, Lu CD, Li C, You X. Mechanism of pyocyanin abolishment caused by mvaT mvaU double knockout in Pseudomonas aeruginosa PAO1. Virulence. 2019 Dec;11(1):57-67.

12. Liang Z, Pang J, Hu X, Nie T, Lu X, Li X, Wang X, Li C, Yang X, You X. Low Prevalence of mcr-1 Among Clinical Enterobacteriaceae Isolates and Co-transfer of mcr-1 and blaNDM-1 from Separate Donors. Microb Drug Resist. 2021 Apr;27(4):476-484.

13. Li X, Wang P, Hu X, Zhang Y, Lu X, Li C, Nie T, Li G, Wang X, Pang J, Lu Y, Yang X, You X. The combined antibacterial effects of sodium new houttuyfonate and berberine chloride against growing and persistent methicillin-resistant and vancomycin-intermediate Staphylococcus aureus. BMC Microbiol. 2020 Oct 19;20(1):317.

14. Fan TY, Wang YX, Tang S, Hu XX, Zen QX, Pang J, Yang YS, You XF, Song DQ. Synthesis and antibacterial evaluation of 13-substituted cycloberberine derivatives as a novel class of anti-MRSA agents. Eur J Med Chem. 2018,157:877-886.

15. Zhang Y, Wang X, Li X, Dong L, Hu X, Nie T, Lu Y, Lu X, Pang J, Li G, Yang X, Li C, You X. Synergistic effect of colistin combined with PFK-158 against colistin-resistant Enterobacteriaceae. Antimicrob Agents Chemother. 2019 Apr 15

16. Wang Q, Lv Y, Pang J, Li X, Lu X, Wang X, Hu X, Nie T, Yang X, Xiong YQ, Jiang J, Li C, You X. In vitro and in vivo activity of d-serine in combination with β-lactam antibiotics against methicillin-resistant Staphylococcus aureus. Acta Pharm Sin B. 2019 May;9(3):496-504.

17. Yang YS, Wei W, Hu XX, Tang S, Pang J, You XF, Fan TY, Wang YX, Song DQ. Evolution and Antibacterial Evaluation of 8-Hydroxy-cycloberberine Derivatives as a Novel Family of Antibacterial Agents Against MRSA. Molecules. 2019 Mar 11;24(5)

18. Yang YS, Lu X, Zeng QX, Pang J, Fan TY, You XF, Tang S, Wang YX, Song DQ. Synthesis and biological evaluation of 7-substituted cycloberberine derivatives as potent antibacterial agents against MRSA. Eur J Med Chem. 2019 Apr 15

19. Fan TY, Wang YX, Tang S, Hu XX, Zen QX, Pang J, Yang YS, You XF, Song DQ. Synthesis and antibacterial evaluation of 13-substituted cycloberberine derivatives as a novel class of anti-MRSA agents. Eur J Med Chem. 2018,157:877-886.

20. Amaraneni M, Pang J, Bruckner JV, Muralidhara S, Mortuza TB, Gullick D, Hooshfar S, White CA, Cummings BS. Influence of Maturation on In Vivo Tissue to Plasma Partition Coefficients for Cis- and Trans-Permethrin. J Pharm Sci. 2017, 106(8):2144-2151

21. Amaraneni M, Pang J, Mortuza TB, Muralidhara S, Cummings BS, White CA, Vorhees CV, Zastre J, Bruckner JV. Brain uptake of deltamethrin in rats as a function of plasma protein binding and blood-brain barrier maturation. Neurotoxicology. 2017, 62:24-29.

22. Zhai Q, Pang J, Li G, Li C, Yang X, Yu L, Wang Y, Li J, You X. Validated LC--MS/MS method for determination of YH-8, a novel PKnB inhibitor, in rat plasma and its application to pharmacokinetic study. Acta Pharm Sin B. 2015 Sep;5(5):467-72.

23. Amaraneni M, Sharma A, Pang J, Muralidhara S, Cummings BS, White CA, Bruckner JV, Zastre J. Plasma protein binding limits the blood brain barrier permeation of the pyrethroid insecticide, deltamethrin. Toxicol Lett. 2016, 21-28.

24. Zhai Qianqian, Pang Jing, Li Guoqing, Li Congran, Wang Yucheng, Yu Liyan, Li Jian, You Xuefu. Preclinical pharmacokinetic analysis of (E)-methyl-4-aryl-4-oxabut-2-enoate, a novel Ser/Thr protein kinase kinaseB inhibitor, in rats. Acta Poloniae Pharmaceutica-Drug Research. 2017, 74:299-307.

25. Li CR, Zhai QQ, Wang XK, Hu XX, Li GQ, Zhang WX, Pang J, Lu X, Yuan H, Gordeev MF, Chen LT, Yang XY, You XF. In vivo antibacterial activity of MRX-I, a new oxazolidinone. Antimicrob Agents Chemother. 2014;58(4):2418-21

专利：

1. 发明人：游雪甫，王根柱，李聪然，杨信怡，王秀坤，熊雁琼，庞晶，卢曦，胡辛欣，聂彤颖，李雪，卢芸。发明名称：瑞香素在抗幽门螺杆菌中的应用。ZL201711240522.9[P], 2020.02.18。

2. 发明人：游雪甫，张友文，胡辛欣，李雪，王秀坤，董立民，杨信怡，李聪然，李国庆，庞晶，卢曦，卢芸，聂彤颖 发明名称：杂环丙烯酮类化合物作为抗菌剂的用途 专利号：CN201811539050 .1[P]

3. 李聪然，游雪甫，张健美，胡辛欣，王青，杨信怡，李国庆，张伟新，王秀坤，庞晶。一种抗菌药物组合物及其应用。2013.1.16-2032.9.10，中国，CN201210333694.1。

专著：高等药理学（第二版），科学出版社，2019.7.编者。

联系电话：010-67058991；15810286349

电子邮箱：pangjing@imb.pumc.edu.cn