微生物与生化药学——药理学方向

王真

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时间:2021-07-02    

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王真   生化室副主任   研究员   博士生导师

教育背景及工作经历:1997年毕业于山东医科大学临床医学专业,获学士学位;2002年毕业于中国协和医科大学微生物与生化药学专业,获博士学位。2002年起在中国医学科学院医药生物技术研究所工作至今。曾分别在新加坡基因组研究所及美国密歇根大学进行博士后和访问学者研究。

主要研究方向:围绕泛素蛋白酶体途径介导的蛋白质降解程序研究肿瘤和骨代谢发生的分子机制,并寻找有效的药物干预分子靶标,进行候选新药的发现和作用机制研究

代表性论文:

1. Zhao X, Lin S, Li H, Si S*, Wang Z*. Myeloperoxidase controls bone turnover by suppressing osteoclast differentiation through modulating reactive oxygen species level. J Bone Mineral Res. 2021, 36(3):591-603.

2. Lin S, Zhao X, Wang Z*. TANK-binding kinase 1 mediates osteoclast differentiation by regulating NF-kB, MAPK and Akt signaling pathways. Immunology & Cell Biology. 2021, 99(2):223-233.

3. Shen J, Zhan Y, Li H and Wang Z*, Ouabain impairs cancer metabolism and activates AMPK-Src signaling pathway in human cancer cell lines. Acta Pharmacologica Sinica. 2019, i0:1-9.

4. Shen J, Li P, Shao X, Yang Y, Liu XJ, Feng M, Yu Q, Hu R*, Wang Z*. The E3 ligase RING1 targets p53 for degradation and promotes cancer cell proliferation and survival. Cancer Research. 2018;78(2):359-371.

5. Sha MQ, Zhao XL, Li L, Li LH, Li Y, Dong TG, Niu WX, Jia LJ, Shao RG, Zhen YS, Wang Z*. EZH2 mediates lidamycin-induced cellular senescence through regulating p21 expression in human colon cancer cells. Cell Death Dis. 2016, 24;7(11):e2486.

6. Sha M, Mao G, Wang G, Chen Y, Wu X, Wang Z*. DZNep inhibits the proliferation of colon cancer HCT116 cells by inducing senescence and apoptosis. Acta Pharmaceutica Sinica B. 2015; 5(3):188-193.

7. Wang Y, Zhan Y, Xu R, Shao R, Jiang J*, Wang Z*. Src mediates extracellular signal-regulated kinase 1/2 activation and autophagic cell death induced by cardiac glycosides in human non-small cell lung cancer cell lines. Molecular Carcinogenesis. 2015;54 Suppl 1:E26-34.

8. Ji X, Xue S, Zhan Y, Shen J, Wu L, Jin J, Wang Z*, Li Z*. Design, synthesis and antiproliferative activity of a novel class of indole-2-carboxylate derivatives. European Journal of Medicinal Chemistry. 2014, 83C:409-418.

9.Wang Y, Qiu Q, Shen JJ, Li DD, Jiang Xuejun, Si Suyi, Shao RG, Wang Z*. Cardiac glycosides induce autophagy in human non-small cell lung cancer cells through regulation of dual signaling pathways. International Journal of Biochemistry & Cell Biology. 2012, 44:1813-1824.

10.Wang Z, Zheng M, Li Z, Li R, Jia L, Xiong X, Southall N, Wang S, Xia M, Austin CP, Zheng W, Xie Z, Sun Y*. Cardiac Glycosides Inhibit p53 Synthesis by a Mechanism Relieved by Src or MAPK Inhibition. Cancer Research. 2009, 69(16): 6556-6564.

专利:第一发明人获授权专利五项:ZL201811368333.4; ZL2018113671892; ZL201510319767.5; ZL201110007943.3; ZL200910136168.4

专著:«分子细胞生物学»(编委2012);衰老分子生物学(副主译2009);«当代药理学»(编委2008

荣誉奖励:中国药理学会Servier青年药理工作者奖(2013);中国药学会赛诺菲-安万特青年生物药物奖(2009);北京市科学技术奖(2005);北京市科技新星(2004)。

学术任职:中国抗癌协会青年理事会理事、中国抗癌协会抗癌药物委员会常委、中国老年学和老年医学学会抗衰老专业委员会委员、美国AACR active member等。

联系电话:010-63165289

电子邮箱:wangzhen@imb.pumc.edu.cn