甘茂罗   国家新药（微生物）筛选室   研究员   博士生导师

教育背景及工作经历：

2005/09-2008/07 北京协和医学院 药物化学 博士

2008/09-2012/09 中国医学科学院医药生物技术研究所 助理研究员

2012/10-2014/09 中国医学科学院医药生物技术研究所 副研究员

2014/10-2015/10 英国圣安德鲁斯大学 访问学者

2015/10-2019/09 中国医学科学院医药生物技术研究所 副研究员

2019/10-至今 中国医学科学院医药生物技术研究所 研究员

主要研究方向：微生物天然产物发现与基因组挖掘

专业研究领域：

1.微生物天然产物研究：以海洋等特境微生物为重点，发现具有抗耐药、抗病毒、抗肿瘤等活性的新型微生物天然产物。

2.微生物基因组挖掘与生物合成机制解析：运用多种沉默基因激活策略，发掘微生物次级代谢潜能，发现沉默基因表达的新型活性产物并解析其生物合成机制。

代表性论文：

1.Xiaomeng Hao, Shasha Li, Jianrui Li, Guiyang Wang, Jiao Li, Zonggen Peng*, Maoluo Gan*. Acremosides A–G, Sugar Alcohol-Conjugated Acyclic Sesquiterpenes from a Sponge-Derived Acremonium Species. J. Nat. Prod. 2024, 87, 1059-1066.

2.Qin Li#, Shasha Li#, Shunwang Li, Xiaomeng Hao, Anqi Wang, Shuyi Si, Yanni Xu, Jicheng Shu*, Maoluo Gan*. Antimicrobial and Anti-inflammatory Cyclic Tetrapeptides from the Co-cultures of Two Marine-Derived Fungi. J. Nat. Prod. 2024, 87, 365-370.

3.Xiaohong Zhu, Anqi Wang, Yifan Zheng, Dan Li, Yuanjuan Wei, Maoluo Gan*, Yan Li*, Shuyi Si. Anti-Biofilm Activity of Cocultimycin A against Candida albicans. Inter. J. Mol. Sci. 2023, 24, 17026. (IF: 5.6)

4.Shanshan Chang#, Meilian Cai#, Tongmei Xiao, Yuchuan Chen, Wuli Zhao, Liyan Yu, Rongguang Shao, Wei Jiang, Tao Zhang, Maoluo Gan*, Shuyi Si*, Minghua Chen*. Prenylemestrins A and B: Two Unexpected Epipolythiodioxopiperazines with a Thioethanothio Bridge from Emericella sp. Isolated by Genomic Analysis. Org. Lett. 2022, 24, 5941-5945. (IF: 6.072)

5.Xiaomeng Hao#, Shasha Li#, Guiyang Wang, Jianrui Li, Zonggen Peng, Yuqin Zhang, Liyan Yu, Maoluo Gan*. Zelkovamycins F and G, Cyclopeptides with Cα-Methyl-threonine Residues, from an Endophytic Kitasatospora sp. J. Nat. Prod. 2022, 85, 1715-1722. (IF: 5.1)

6.Xiaomeng Hao#, Shasha Li#, Jun Ni, Guiyang Wang, Fang Li, Qin Li, Shuzhen Chen, Jicheng Shu*, Maoluo Gan*. Acremopeptaibols A–F, 16-Residue Peptaibols from the Sponge-Derived Acremonium sp. IMB18-086 Cultivated with Heat-Killed Pseudomonas aeruginosa. J. Nat. Prod. 2021, 84, 2990-3000. (IF: 4.803)

7.Xiangjian Zhong#, Xin Wang#, Na Zhou, Jinjie Li, Jiachen Liu, Jianyu Yue, Xiaomeng Hao, Maoluo Gan*, Pengcheng Lin, Xiaoya Shang*. Chemical characterization of the polar antibacterial fraction of the ethanol extract from Rosmarinus officinalis. Food Chem. 2021, 344, 128674. (IF:6.306)

8.Jin-Yao Yong#, Wen-Rui Li#, Xiao-jing Wang, Guo-Zhu Su, Mi Li, Jian-Pei Zhang, Hong-Li Jia, Yu-Huan Li, Ru-Bing Wang*, Maoluo Gan*, Shuang-Gang Ma*. Illihenin A: An Antiviral Sesquiterpenoid with a Cage-like Tricyclo[6.2.2.01,5]dodecane Skeleton from Illicium henryi. J. Org. Chem. 2021, 86, 2017-2022. (IF:4.335)

9.Jiao Li#, Minghua Chen#, Xiaomeng Hao#, Shasha Li, Fang Li, Liyan Yu, Chunling Xiao, Maoluo Gan*. Structural Revision and Absolute Configuration of Burnettramic Acid A. Org. Lett. 2020, 22, 98-101. (IF: 6.091)

10.Xiaomeng Hao, Jiaqing Yu, Yujia Wang, Jack A. Connolly, Yufeng Liu, Yuqin Zhang, Liyan Yu, Shan Cen*, Rebecca J. M. Goss*, Maoluo Gan*. Zelkovamycins B–E, Cyclic Octapeptides Containing Rare Amino Acid Residues from an Endophytic Kitasatospora sp. Org. Lett. 2020, 22, 9346–9350. (IF:6.091)

11.Jiao Li#, Yuanyuan Hu#, Xiaomeng Hao, Jiali Tan, Fang Li, Xinran Qiao, Shuzhen Chen, Chunling Xiao, Minghua Chen*, Zonggen Peng*, Maoluo Gan*. Raistrickindole A, an Anti-HCV Oxazinoindole Alkaloid from Penicillium raistrickii IMB17-034. J. Nat. Prod. 2019, 82, 1391-1395. （IF: 3.779）

12.Minghua Chen#, Renzhong Wang#, Wuli Zhao, Liyan Yu, Conghui Zhang, Shanshan Chang, Yan Li, Tao Zhang, Jianguo Xing, Maoluo Gan*, Feng Feng*, Shuyi Si*. Isocoumarindole A, a Chlorinated Isocoumarin and Indole Alkaloid Hybrid Metabolite from an Endolichenic Fungus Aspergillus sp. Org. Lett. 2019, 21, 1530-1533. （IF: 6.091）

13.Christopher S. Bailey, Joseph Zarins Tutt, Mathias Onyebuchi Agbo, Hong Gao, Alberto Diego-Taboada, Maoluo Gan, Refaat B. Hamed, Emily Abraham, Grahame Mackenzie, P. Andrew Evans, Rebecca Jane Miriam Goss. A Natural Solution to Photoprotection and Isolation of the Potent Polyene Antibiotic, Marinomycin A. Chem. Sci. 2019, 10, 7549-7553. (IF:9.556)

14.Bin Liu#, Jiao Li#, Minghua Chen, Xiaomeng Hao, Fei Cao, Yi Tan, Yuhui Ping, Yiguang Wang, Chunling Xiao, Maoluo Gan*. Seco-Tetracenomycins from the Marine-Derived Actinomycete Saccharothrix sp. 10-10. Mar. Drugs 2018, 16, 345. （IF:3.772）

15.Yuanyuan Hu#, Mian Wang#, Chunyan Wu, Yi Tan, Jiao Li, Xiaomeng Hao, Yanbo Duan, Yan Guan, Xiaoya Shang, Yiguang Wang, Chunling Xiao, Maoluo Gan*. Identification and proposed relative and absolute configurations of niphimycins C–E from the marine-derived Streptomyces sp. IMB7-145 by genomic analysis. J. Nat. Prod. 2018, 81, 178-187. （IF: 4.257）

#：并列一作；*：通讯作者

专利：

1.甘茂罗，郝晓萌，张玉琴，岑山，余利岩，彭宗根，王宇佳，李健蕊.环肽化合物及其制备方法和抗病毒用途. 专利号：ZL202011238493.4。

2.甘茂罗，肖春玲，王冕，郝晓萌，李娇，胡媛媛，刘忆霜，关艳，王以光，周红霞. 一种产星形孢菌素的海洋链霉菌及其制备方法. 专利号：ZL201810075696.2。

3.甘茂罗，胡媛媛，李娇，陈明华，郝晓萌，肖春玲，彭宗根. 雷斯吲哚甲及其制备方法和抗丙型肝炎病毒用途.  专利号：ZL201910241023.4。

4.甘茂罗 ,李娇, 陈明华, 郝晓萌, 李莎莎, 李芳. 海洋曲霉菌产生的抗真菌化合物及其制备方法. 专利号：ZL201911156556.9。

5.甘茂罗，王以光，肖春玲，谭亿，吴春彦，周红霞，洋橄榄叶素衍生物及其在抗耐药菌和耐药结核分枝杆菌感染中的应用. 专利号：ZL201310658925.0。

专著：

1.石建功主编，甘茂罗副主编. 《木脂素化学》. 化学工业出版社，北京2010年1月第1版。

2.方起程主编《天然药物化学研究》.中国协和医科大学出版社，北京2006年9月第1版。

荣誉奖励：2015年度中国药学会-赛诺菲青年生物药物奖

学术任职：中国药理学会海洋药物专业委员会委员；中国化学会高级会员

联系电话：010-63165277

电子邮箱：ganml@imb.pumc.edu.cn