微生物与生化药学——微生物学方向

甘茂罗

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时间:2021-07-01    

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甘茂罗   国家新药(微生物)筛选室   研究员   博士生导师

教育背景及工作经历:

2019/10-至今 中国医学科学院医药生物技术研究所 研究员

2015/10-2019/09 中国医学科学院医药生物技术研究所 副研究员

2014/10-2015/10 英国圣安德鲁斯大学 访问学者

2012/10-2014/09 中国医学科学院医药生物技术研究所 副研究员

2008/09-2012/09 中国医学科学院医药生物技术研究所 助理研究员

2005/09-2008/07 北京协和医学院 药物化学 博士

2002/09-2005/07 江西中医学院 药物化学 硕士

主要研究方向:微生物天然产物发现与基因组挖掘

专业研究领域:

1.微生物天然产物研究:以海洋(放线菌和真菌)等特境微生物为研究重点,基于活性筛选和化学排重以发现具有抗耐药、抗病毒、抗肿瘤等活性的新型抗生素

2.微生物基因组挖掘与生物合成:运用多种策略激活菌株沉默基因表达,发掘微生物次级代谢潜能以发现沉默基因编码的新型活性分子,并对其生物合成通路开展研究

代表性论文:

1.Xiangjian Zhong#, Xin Wang#, Na Zhou, Jinjie Li, Jiachen Liu, Jianyu Yue, Xiaomeng Hao, Maoluo Gan*, Pengcheng Lin, Xiaoya Shang*. Chemical characterization of the polar antibacterial fraction of the ethanol extract from Rosmarinus officinalis. Food Chem. 2021, 344, 128674. (IF:6.306,并列通讯)

2.Jin-Yao Yong#, Wen-Rui Li#, Xiao-jing Wang, Guo-Zhu Su, Mi Li, Jian-Pei Zhang, Hong-Li Jia, Yu-Huan Li, Ru-Bing Wang*, Maoluo Gan*, Shuang-Gang Ma*. Illihenin A: An Antiviral Sesquiterpenoid with a Cage-like Tricyclo[6.2.2.01,5]dodecane Skeleton from Illicium henryi. J. Org. Chem. 2021, 86, 2017-2022. (IF:4.335,并列通讯)

3.Jiao Li#, Minghua Chen#, Xiaomeng Hao#, Shasha Li, Fang Li, Liyan Yu, Chunling Xiao, Maoluo Gan*. Structural Revision and Absolute Configuration of Burnettramic Acid A. Org. Lett. 2020, 22, 98-101. (IF: 6.091, 通讯作者)

4.Xiaomeng Hao, Jiaqing Yu, Yujia Wang, Jack A. Connolly, Yufeng Liu, Yuqin Zhang, Liyan Yu, Shan Cen*, Rebecca J. M. Goss*, Maoluo Gan*. Zelkovamycins B–E, Cyclic Octapeptides Containing Rare Amino Acid Residues from an Endophytic Kitasatospora sp. Org. Lett. 2020, 22, 9346–9350. (IF:6.091,第一通讯)

5.Xinran Qiao#, Maoluo Gan#, Chen Wang, Bin Liu, Yue Shang, Yi Li, Shuzhen Chen*. Tetracenomycin X Exerts Antitumour Activity in Lung Cancer Cells through the Downregulation of Cyclin D1. Mar. Drugs 2019, 17, 63. IF:4.073,并列一作)

6.Jiao Li#, Yuanyuan Hu#, Xiaomeng Hao, Jiali Tan, Fang Li, Xinran Qiao, Shuzhen Chen, Chunling Xiao, Minghua Chen*, Zonggen Peng*, Maoluo Gan*. Raistrickindole A, an Anti-HCV Oxazinoindole Alkaloid from Penicillium raistrickii IMB17-034. J. Nat. Prod. 2019, 82, 1391-1395. IF: 3.779,通讯作者)

7.Minghua Chen#, Renzhong Wang#, Wuli Zhao, Liyan Yu, Conghui Zhang, Shanshan Chang, Yan Li, Tao Zhang, Jianguo Xing, Maoluo Gan*, Feng Feng*, Shuyi Si*. Isocoumarindole A, a Chlorinated Isocoumarin and Indole Alkaloid Hybrid Metabolite from an Endolichenic Fungus Aspergillus sp. Org. Lett. 2019, 21, 1530-1533. IF: 6.091, 并列通讯)

8.Christopher S. Bailey, Joseph Zarins Tutt, Mathias Onyebuchi Agbo, Hong Gao, Alberto Diego-Taboada, Maoluo Gan, Refaat B. Hamed, Emily Abraham, Grahame Mackenzie, P. Andrew Evans, Rebecca Jane Miriam Goss. A Natural Solution to Photoprotection and Isolation of the Potent Polyene Antibiotic, Marinomycin A. Chemical Science 2019, 10, 7549-7553. (IF:9.556)

9.Bin Liu#, Jiao Li#, Minghua Chen, Xiaomeng Hao, Fei Cao, Yi Tan, Yuhui Ping, Yiguang Wang, Chunling Xiao, Maoluo Gan*. Seco-Tetracenomycins from the Marine-Derived Actinomycete Saccharothrix sp. 10-10. Mar. Drugs 2018, 16, 345. IF:3.772,通讯作者)

10.Yuanyuan Hu#, Mian Wang#, Chunyan Wu, Yi Tan, Jiao Li, Xiaomeng Hao, Yanbo Duan, Yan Guan, Xiaoya Shang, Yiguang Wang, Chunling Xiao, Maoluo Gan*. Identification and proposed relative and absolute configurations of niphimycins C–E from the marine-derived Streptomyces sp. IMB7-145 by genomic analysis. J. Nat. Prod. 2018, 81, 178-187. IF: 4.257,通讯作者)

11.Qiang Wang, Yixuan Zhang, Mian Wang, Yi Tan, Xinxin Hu, Hongwei He, Chunling Xiao, Xuefu You, Yiguang Wang, Maoluo Gan*. Neo-actinomycins A and B, natural actinomycins bearing the 5H-oxazolo[4,5-b]phenoxazine chromophore, from the marine-derived Streptomyces sp. IMB094. Sci. Rep. 2017, 7, 3591. (IF:4.112,通讯作者)

12.Yi Tan, Yuanyuan Hu, Qiang Wang, Hongxia Zhou, Yiguang Wang, Maoluo Gan*. Tetrocarcins N and O, glycosidic spirotetronates from a marine-derived Micromonospora sp. identified by PCR-based screening. RSC Advances 2016, 6, 91773-91778. (IF: 3.108,通讯作者)

13.Maoluo Gan#,*, Bin Liu, Yi Tan#, Qiang Wang, Hongxia Zhou, Hongwei He, Yuhui Ping, Zhaoyong Yang, Yiguang Wang, Chunling Xiao*. Saccharothrixones A–D, Tetracenomycin-Type Polyketides from the Marine-Derived Actinomycete Saccharothrix sp. 10-10. J. Nat. Prod. 2015, 78, 2260-2265. IF: 3.798)

14.Chunyan Wu, Yi Tan, Maoluo Gan*, Yiguang Wang, Yan Guan, Xinxin Hu, Hongxia Zhou, Xiaoya Shang, Xuefu You, Zhaoyong Yang, Chunling Xiao. Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening. J. Nat. Prod. 2013, 76, 2153-2157. (IF: 3.798, 通讯作者)

15.Maoluo Gan, Yufeng Liu, Yinlei Bai, Yan Guan, Li Li, Rongmei Gao, Weiying He, Xuefu You, Yuhuan Li, Liyan Yu, Chunling Xiao. Polyketides with New Delhi Metallo-β-lactamase 1 Inhibitory Activity from Penicillium sp. J. Nat. Prod. 2013, 76, 1535-1540. (IF: 3.798)

专利:

1.甘茂罗,郝晓萌,张玉琴,岑山,余利岩,彭宗根,王宇佳,李健蕊.环肽化合物及其制备方法和抗病毒用途 专利申请号:202011238493.4

2.甘茂罗,胡媛媛,李娇,陈明华,郝晓萌,肖春玲,彭宗根. 一种制备抗丙型肝炎病毒活性化合物雷斯吲哚甲的海洋青霉菌.专利申请号:202010224119.2

3.甘茂罗,肖春玲,王冕,郝晓萌,李娇,胡媛媛,刘忆霜,关艳,王以光,周红霞. 一种产星形孢菌素的海洋链霉菌及其制备方法,专利号:ZL201810075696.2

4.甘茂罗,胡媛媛,李娇,陈明华,郝晓萌,肖春玲,彭宗根. 雷斯吲哚甲及其制备方法和抗丙型肝炎病毒用途. 专利号:ZL201910241023.4

5.甘茂罗 ,李娇, 陈明华, 郝晓萌, 李莎莎, 李芳. 海洋曲霉菌产生的抗真菌化合物及其制备方法,专利申请号:201911156556.9

6.甘茂罗,王强,王冕,胡媛媛,谭亿,何红伟,王以光,肖春玲,周红霞. 新放线菌素A及其制备方法和用途,专利号:ZL201710154052.8

7.甘茂罗,王以光,肖春玲,谭亿,吴春彦,周红霞,洋橄榄叶素衍生物及其在抗耐药菌和耐药结核分枝杆菌感染中的应用. 专利号:ZL201310658925.0

专著:

1、石建功主编,甘茂罗副主编. 《木脂素化学》. 化学工业出版社,北京20101月第1版。

2、方起程主编《天然药物化学研究》.中国协和医科大学出版社,北京20069月第1版。

荣誉奖励:2015年度中国药学会-赛诺菲青年生物药物奖

学术任职:中国药理学会海洋药物专业委员会委员;中国药学会高级会员;中国化学会会员

联系电话:010-63165277

电子邮箱:ganml@imb.pumc.edu.cn