Name：WANG Jing

Department：Immunology

Tel: (8610)63131011

Email: jingwang@imb.pumc.edu.cn

Education & Research Experience

2019/10 – Now Associate Professor, Institute of Medicinal Biotechnology, Chinese Academy of Medical Science

2013/09 –2019/09 Assistant Professor, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences

2008/09 –2013/07 Ph.D. in biochemistry and molecular biology, Peking Union Medical College

2004/09 –2008/07 B.S. in biology science, Minzu University of China

Research Field：

Basic research in virology and application of antiviral drugs

Research Interests：

Dr. Wang has been engaged in the virus-host interaction and identification of potential antiviral drug targets. In recent years, she has focused on the roles and molecular mechanisms of host lncRNAs in IAV replication. A group of functional lncRNAs were identified in a loss-of-function screen, and further study first revealed the important roles and novel mechanisms of the candidate lncRNAs in IAV replication. These findings help to unravel a complete IAV-lncRNA regulatory network and may open avenues to the development of antiviral therapeutics.

Selected Publications

1. Jing Wang^#, Yongxin Zhang^#, Quanjie Li, Jianyuan Zhao, Dongrong Yi, Jiwei Ding, Fei Zhao, Siqi Hu, Jinming Zhou, Tao Deng, Xiaoyu Li*, Fei Guo, Chen Liang, and Shan Cen*, Influenza virus exploits an interferon-independent lncRNA to preserve viral RNA synthesis through stabilizing viral RNA polymerase PB1. Cell Reports, 2019, 27, 3295–3304.

2. Jing Wang* and Shan Cen*. Roles of lncRNAs in influenza virus infection. Emerg Microbes Infect. 2020, 9 (1):1407-1414.

3. Jing Wang, Yujia Wang, Rui Zhou, Jianyuan Zhao, Yongxin Zhang, Dongrong Yi, Quanjie Li, Jinming Zhou, Fei Guo, Chen Liang, Xiaoyu Li and Shan Cen*, Host long noncoding RNA lncRNA-PAAN regulates the replication of Influenza A Virus. Viruses, 2018, 10, 330.

4. Ling-xia Wang^#, Jing Wang^#, Ting-ting Qu, Ye Zhang*, Yu-fei Shen*, Reversible acetylation of Lin28 mediated by PCAF and SIRT1. Biochimica et Biophysica Acta: Molecular Cell Research, 2014, 1843(6): 1188-1195.

5. Jianyuan, Saisai Guo, Dongrong Yi, Quanjie Li, Ling Ma, Yongxin Zhang, Jing Wang, Xiaoyu Li, Fei Guo, Rongtuan Lin, Chen Liang, Zhenlong Liu*, Shan Cen*, A cell-based assay to discover inhibitors of SARS-CoV-2 RNA dependent RNA polymerase. Antiviral Research.

6. Dong-Rong Yi^#, Ni An^#, Zhen-Long Liu, Feng-Wen Xu, Kavita Raniga, Quan-Jie Li, Rui Zhou, Jing Wang, Yong-Xin Zhang, Jin-Ming Zhou, Lei-Liang Zhang, Jing An, Cheng-Feng Qin, Fei Guo, Xiao-Yu Li, Chen Liang, Shan Cen*, Human MxB inhibits the replication of hepatitis C virus. J Virol, 2019, 93:e01285-18.

7. Quanjie Li^#, Ling Ma^#, Dongrong Yi^#, Han Wang, Jing Wang, Yongxin Zhang, Ying Guo, Xiaoyu Li, Jinming Zhou*, Yi Shi*, George F. Gao, Shan Cen*, Novel cyclo-peptides inhibit Ebola pseudotyped virus entry by targeting primed GP protein. Antiviral Res., 2018, 155:1-11.

8. Ling Ma, Zhixin Zhang, Zhenlong Liu, Qinghua Pan, Jing Wang, Xiaoyu Li, Fei Guo, Chen Liang, HuLaixing Hu, Jinming Zhou*, Shan Cen*, Identification of small molecule compounds targeting the interaction of HIV-1 Vif and human APOBEC3G by virtual screening and biological evaluation. Sci Rep., 2018, 8(1):8067.

9. Ting-ting Qu^#, Fei Chen^#, Jing Wang, Yan-jun Zhang, Mo-bin Cheng, Wen-zheng Sun, Yu-fei Shen and Ye Zhang*, PCAF-mediated acetylation of Lin28B increases let-7 biogenesis in lung adenocarcinoma H1299 cells. BMC Cancer, 2018, 18: 27.

10. Congjie Zhai, Ling Ma, Zhixin Zhang, Jiwei Ding, Jing Wang, Yongxin Zhang, Xiaoyu Li, Fei Guo, Liyan Yu, Jinming Zhou, Shan Cen*, Identification and characterization of loop7 motif and its role in regulating biological function of human APOBEC3G through molecular modeling and biological assay. Acta Pharm Sin B, 2017,7(5):571-582.

11. Quan Zhang^#, Zeyun Mi^#, Yuming Huang^#, Ling Ma, Jiwei Ding, Jing Wang, Yongxin Zhang, Yang chen, Jinming Zhou, Fei Guo, Xiaoyu Li and Shan Cen*, 2-thio-6-azauridine inhibits Vpu mediated BST-2 degradation. Retrovirology, 2016, 13:13.