Name：Jing Pang

Department：Pharmacology

Tel: (8610)67058991

Email: pangjing@imb.pumc.edu.cn

Education & Research

2019/9-Now, Associate Professor, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences

2012/6-2019/8, Assistant Professor, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences

2007/9-2012/6 Ph.D. in microbial and biochemical pharmacy, Peking Union Medical College

2003/9-2007/6 Bachelor in pharmacy, Xiangya Medical School of Central South University.

2014/4-2015/12 Postdoctoral, University of Georgia

Research Field：

Pharmacokinetics, Pharmacology of antimicrobial agent

Research Interests：

Dr. Pang’s research encompasses pharmacokinetics, and PKPD study of antimicrobial agents. Besides, she devotes to the discovery, pharmacodynamic and mechanisms of action study of the new antibacterial compounds.

Selected Publications

1. Pang J, Mortuza T, White CA, Muralidhara S, Cummings BS, Bruckner JV. Toxicokinetics of cis- and trans-Permethrin: Influence of Isomer, Maturation, and Sex. Toxicol Sci. 2020 Mar 1;174(1):25-37.

2. Fan T, Guo X, Zeng Q, Wei W, You X, Wang Y, Pang J*, Song D. Synthesis and Structure-Activity Relationship of Palmatine Derivatives as a Novel Class of Antibacterial Agents against Helicobacter pylori.Molecules. 2020 Mar 16;25(6):1352. doi: 10.3390/molecules25061352.

3. He S, Chen HT, Zhao R, Hu XX, Nie TY, Yang XY, Li CR, Lu X, Wang XK, Li X, Lu Y, Li GQ, Pang J*, You XF. Development and validation of a sensitive LC-MS/MS method for the quantitation of IMB-YH-4py5-2H, an antituberculosis candidate, and its application to the pharmacokinetic study. PLoS One. 2020 Feb 19;15(2):e0228797.

4. Wang G*, Pang J*, Hu X, Nie T, Lu X, Li X, Wang X, Lu Y, Yang X, Jiang J, Li C, Xiong YQ, You X. Daphnetin: A Novel Anti-Helicobacter pylori Agent. Int J Mol Sci. 2019 Feb 15;20(4).

5. Pang J, Li CR, Zhao R, Nie TY, Li GQ, Lu X, Hu XX, Wang XK, Yang XY, You XF. Simplified LC-MS/MS method for quantification of IG-105, a novel tubulin ligand, and its application to the pharmacokinetic study in rats at the anticancer effective dose. Pharmazie. 2019 Feb 1;74(2):79-82

6. Pang J, Li GQ, Li CR, Yang XY, Lu X, Hu XX, Zhai QQ, Zhang WX, Jiang JD, You XF. Toxicokinetic study of melamine in the presence and absence of cyanuric acid in rats.J Appl Toxicol. 2013 Jun;33(6):444-50.

7. Dong L, Pang J, Wang X, Zhang Y, Li G, Hu X, Yang X, Lu CD, Li C, You X. Mechanism of pyocyanin abolishment caused by mvaT mvaU double knockout in Pseudomonas aeruginosa PAO1. Virulence. 2019 Dec;11(1):57-67.

8. Liang Z, Pang J, Hu X, Nie T, Lu X, Li X, Wang X, Li C, Yang X, You X. Low Prevalence of mcr-1 Among Clinical Enterobacteriaceae Isolates and Co-transfer of mcr-1 and blaNDM-1 from Separate Donors. Microb Drug Resist. 2021 Apr;27(4):476-484.

9. Li X, Wang P, Hu X, Zhang Y, Lu X, Li C, Nie T, Li G, Wang X, Pang J, Lu Y, Yang X, You X. The combined antibacterial effects of sodium new houttuyfonate and berberine chloride against growing and persistent methicillin-resistant and vancomycin-intermediate Staphylococcus aureus. BMC Microbiol. 2020 Oct 19;20(1):317.

10. Fan TY, Wang YX, Tang S, Hu XX, Zen QX, Pang J, Yang YS, You XF, Song DQ. Synthesis and antibacterial evaluation of 13-substituted cycloberberine derivatives as a novel class of anti-MRSA agents. Eur J Med Chem. 2018,157:877-886.

11. Zhang Y, Wang X, Li X, Dong L, Hu X, Nie T, Lu Y, Lu X, Pang J, Li G, Yang X, Li C, You X. Synergistic effect of colistin combined with PFK-158 against colistin-resistant Enterobacteriaceae. Antimicrob Agents Chemother. 2019 Apr 15

12. Wang Q, Lv Y, Pang J, Li X, Lu X, Wang X, Hu X, Nie T, Yang X, Xiong YQ, Jiang J, Li C, You X. In vitro and in vivo activity of d-serine in combination with β-lactam antibiotics against methicillin-resistant Staphylococcus aureus. Acta Pharm Sin B. 2019 May;9(3):496-504.

13. Yang YS, Wei W, Hu XX, Tang S, Pang J, You XF, Fan TY, Wang YX, Song DQ. Evolution and Antibacterial Evaluation of 8-Hydroxy-cycloberberine Derivatives as a Novel Family of Antibacterial Agents Against MRSA. Molecules. 2019 Mar 11;24(5)

14. Yang YS, Lu X, Zeng QX, Pang J, Fan TY, You XF, Tang S, Wang YX, Song DQ. Synthesis and biological evaluation of 7-substituted cycloberberine derivatives as potent antibacterial agents against MRSA. Eur J Med Chem. 2019 Apr 15

15. Fan TY, Wang YX, Tang S, Hu XX, Zen QX, Pang J, Yang YS, You XF, Song DQ. Synthesis and antibacterial evaluation of 13-substituted cycloberberine derivatives as a novel class of anti-MRSA agents. Eur J Med Chem. 2018,157:877-886.

16. Amaraneni M, Pang J, Bruckner JV, Muralidhara S, Mortuza TB, Gullick D, Hooshfar S, White CA, Cummings BS. Influence of Maturation on In Vivo Tissue to Plasma Partition Coefficients for Cis- and Trans-Permethrin. J Pharm Sci. 2017, 106(8):2144-2151

17. Amaraneni M, Pang J, Mortuza TB, Muralidhara S, Cummings BS, White CA, Vorhees CV, Zastre J, Bruckner JV. Brain uptake of deltamethrin in rats as a function of plasma protein binding and blood-brain barrier maturation. Neurotoxicology. 2017, 62:24-29.

18. Zhai Q, Pang J, Li G, Li C, Yang X, Yu L, Wang Y, Li J, You X. Validated LC--MS/MS method for determination of YH-8, a novel PKnB inhibitor, in rat plasma and its application to pharmacokinetic study. Acta Pharm Sin B. 2015 Sep;5(5):467-72.

19. Amaraneni M, Sharma A, Pang J, Muralidhara S, Cummings BS, White CA, Bruckner JV, Zastre J. Plasma protein binding limits the blood brain barrier permeation of the pyrethroid insecticide, deltamethrin. Toxicol Lett. 2016, 21-28.

20. Zhai Qianqian, Pang Jing, Li Guoqing, Li Congran, Wang Yucheng, Yu Liyan, Li Jian, You Xuefu. Preclinical pharmacokinetic analysis of (E)-methyl-4-aryl-4-oxabut-2-enoate, a novel Ser/Thr protein kinase kinaseB inhibitor, in rats. Acta Poloniae Pharmaceutica-Drug Research. 2017, 74:299-307.

21. Li CR, Zhai QQ, Wang XK, Hu XX, Li GQ, Zhang WX, Pang J, Lu X, Yuan H, Gordeev MF, Chen LT, Yang XY, You XF. In vivo antibacterial activity of MRX-I, a new oxazolidinone. Antimicrob Agents Chemother. 2014;58(4):2418-21