Professor
FU Haigen
Source:
time：2023-05-16
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Name：FU Haigen
Department：Organic Chemistry
Tel: (+86) 18770473850
Email: fuhaigen@imb.pumc.edu.cn
Education & Research Experience
2023/2 – Now Professor, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences
2021/01 – 2023/01 Postdoctoral Fellow, Cornell University
2020/01 – 2020/12 Postdoctoral Fellow, Princeton University
2015/10 – 2019/09 Ph.D. in Pharmaceutical Biology, University of Groningen
2012/09 – 2015/07 M.S. in Microbial and Biochemical Pharmacy, Peking Union Medical College
2008/09 – 2012/07 B.S. in Pharmaceutical Engineering, Qingdao University of Science and Tech
Research Field
Biocatalysis, Medicinal Chemistry
Research Interests
Dr. Fu has been engaged in pushing the boundary of biocatalysis. His group is interested in discovering new enzymes or unlocking new reactivities by exploiting non-natural mechanisms with photochemical strategies to address challenges in organic synthesis. He is also interested in developing enzymatic or chemoenzymatic cascade to prepare chiral pharmaceutical molecules. In Med Chem part, he is interested in developing anti-bacterial/virus drugs.
1. H. Fu, J. Cao, T. Qiao, Y. Qi, S.J. Charnock, S. Garfinkle, T.K. Hyster*. An asymmetric sp3–sp3 cross-electrophile coupling using ‘ene’-reductases. Nature 2022, 610, 302–307.
2. H. Fu#, J. Zhang#, M. Saifuddin#, G. Cruiming, P.G. Tepper, G.J. Poelarends*. Chemoenzymatic asymmetric synthesis of the metallo-β-lactamase inhibitor Aspergillomarasmine A and related aminocarboxylic acids. Nat. Catal., 2018, 1, 186–189.
3. H. Fu#, T. Qiao#, J.M. Carceller, S.N. MacMillan, T.K. Hyster*. Asymmetric C-alkylation of nitroalkanes via enzymatic photoredox catalysis. J. Am. Chem. Soc., 2023, 145, 787–793.
4. H. Fu, H. Lam, M. Emmanuel, J.H. Kim, B.A. Sandoval, T.K. Hyster*. Ground state electron transfer as an initiation mechanism for biocatalytic C–C bond forming reactions. J. Am. Chem. Soc., 2021, 143, 9622–9629.
5. H. Fu, A. Prats-Luján, L. Bothof, J. Zhang, P.G. Tepper, and G.J. Poelarends*. Biocatalytic asymmetric synthesis of N-aryl-functionalized amino acids and substituted pyrazolidinones. ACS Catal., 2019, 9, 7292–7299.
6. H. Fu, J. Zhang, P.G. Tepper, L. Bunch, A.A. Jensen*, and G.J. Poelarends*. Chemoenzymatic synthesis and pharmacological characterization of functionalized aspartate analogues as novel excitatory amino acid transporter inhibitors. J. Med. Chem., 2018, 61, 7741–7753.
Awards and Honors
Reaxys PhD Prize Finalist (2020)
PhD degree with the highest distinction of Cum Laude, University of Groningen (2019)
