Name：Zhang Zhuan

Department：Microbial metabolic engineering Laboratory

Tel: (86)13661784825

Email: zhangzhuan@imb.pumc.edu.cn

Education & Research Experience：

2022/10- Present Assistant Professor, Institute of Medical Biotechnology, Chinese Academy of Medical Science & Peking Union Medical college, Peking, China

2020/08-2022/09 Postdoctoral Research Fellow, The University of Texas Health Science Center at Houston (UThealth), TX, USA.

2017/09-2020/07 Postdoctoral Research Fellow, University of California, Los Angeles (UCLA), CA, USA.

2014/01-2017/07 Research Associate, Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences, Shanghai, China

2008/09-2014/01 Ph.D. Organic chemistry, Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences, Shanghai, China

2004/09-2008/06 B.S.，Chemistry Shannxi Normal University, Xi’an, China

Research Field：

Discovery and innovation of antifungal and immunosuppressive drugs

Research Interests：

Our research goal is to investigate bioactive natural product biosynthetic pathways to discover valuable enzymology as biocatalysts to develop scalable routes for target molecules, to employ genetic engineering to generate chemotherapeutic agents, and to explore bioactive natural products by targeted genome mining.

Selected Publications：

9.  Zhang Z*, Bills Gerald F*, An Z* “Advances in the treatment of invasive fungal

disease”. PLoS Pathog. 2023, 19. e1011322

8.  Zhang Z, Tamura Y, Tang M, Qiao T, Sato M, Otsu Y, Sasamura S, Taniguchi M, Watanabe K*, and Tang Y*. “Biosynthesis of the Immunosuppressant (-)-FR901483”. J Am Chem Soc. 2021, 143, 132-136.

7.  Kim L^*, Ohashi M^*, Zhang Z^*, Tan D, Asay M, Cascio D, Rodriguez J, Tang Y*, and Nelson H*. “Prospecting for natural products by genome mining and microcrystal electron diffraction”. Nat. Chem. Biol. 2021, 17, 872-877 (﹡Co-first author).

6.  Zhang Z, Qiao TZ, Watanabe K*, Tang Y*. “Concise biosynthesis of phenylfuropyridones from fungi”. Angew Chem Int Ed Engl. 2020, 59, 19889-19893.

5.  Hu Y^*, Zhang Z^*, Yin Y, Tang GL*. “Directed Biosynthesis of Iso-aclacinomycins with Improved Anticancer Activity”. Org Lett. 2020, 22, 150-154 (﹡Co-first author).

4.  Zhang Z, Jamieson CS, Zhao YL, Li D, Ohashi M*, Houk KN*, Tang Y*. “Enzyme-Catalyzed Inverse-Electron Demand Diels-Alder Reaction in the Biosynthesis of Antifungal Ilicicolin H”. J Am Chem Soc. 2019, 141, 5659-5663.

3.  Zhang Z^*, Gong YK^*, Zhou Q, Hu Y, Ma HM, Chen YS, Igarashi Y, Pan L*, Tang GL*. “Hydroxyl Regioisomerization of Anthracycline Catalyzed by a Four-enzyme cascade”. Proc Natl Acad Sci U S A. 2017, 114, 1554-1559.

2.  Zhang Z, Pan HX, and Tang GL*, “New Insights into Bacterial Type II Polyketide Biosynthesis”. F1000 Research Rev 172, 2017 (doi:10.12688/f1000research.10466.1).

1.  Ma HM^*, Zhou Q^*, Tang YM^*, Zhang Z^*, Chen YS, He HY, Pan HX, Tang MC, Gao JF, Zhao SY, Igarashi Y, Tang GL*. “Unconventional Origin and Hybrid System for Construction of Pyrrolopyrrole Moiety in Kosinostatin Biosynthesis”. Cell Chem. Biol. 2013, 20, 796–805 (﹡Co-first author).

Awards and Honors：

2022 National Excellent Youth (Overseas)