Name：ZHANG Dewu

Department：China Pharmaceutical Culture Collection

Tel:

Email: zhangdewu@imb.pumc.edu.cn

Education & Research Experience

2016/07 – Now Associate Professor, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences

2013/09 – 2016/07 Assistant Professor, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences

2010/09 – 2013/07 Ph.D. in pharmacognosy, Peking Union Medical College

2007/09 – 2010/07 M.S. in medicinal chemistry, Yantai University

2003/09 – 2007/07 B.S. in pharmacy, Yantai University

Research Field：

Microbial Natural Products Chemistry and Synthetic Biology

Research Interests：

The overall goal of the research is to discovery new biologically active natural products with diverse biological activities from microbes, mainly including actinomycetes and fungi. Our research focused on discovering bioactive novel secondary metabolites from Microorganisms collected from medicinal plants, lichen, desert, Tibet, ocean, and polar region. In the course of the study, synthetic biology approach containing genome mining, gene regulation, and gene knockout were used in order to produce more bioactive molecules. Over fifty articles have been published on Organic Letters, Journal of Natural Products, et al.

Selected Publications

1. Su Cong, Tao Xiaoyu, Yin Zhen, Zhang Xiaolin, Tian Jinying, Chen Ridao, Liu Jimei, Li Li, Ye Fei, Zhang Peicheng, Zhang Dewu*, Dai Jujgui*. Morusalones A-D, Diels-Alder adducts with 6/7/6/6/6/6 hexacyclic ring systems as potential PTP1B inhibitors from cell culutres of Morus alba. Org. Lett. 2019, 21: 9463-9467.

2. Fan Yijun^#, Zhang Dewu^#, Tao Xiaoyu, Wang Yuanhao, Liu Jimei, Li Li, Zhao Jianyuan, Yu Liyan, He Yupeng, Dai Jungui*, Tang Yefeng*. Biosynthetic hypothesis-guided discovery and total syntheses of PKS-NRPS hybrid metabolites from endophytic fungus Periconia species. Org. Lett. 2019, 21: 1794-1798. (# co-first author)

3. Zhang Dewu, Tao Xiaoyu, Chen Ridao, Liu Jimei, Li Li, Fang Xiaomei, Yu Liyan, Dai Jungui *. Pericoannosin A, a polyketide synthase-nonribosomal peptide synthetase hybrid metabolite with new carbon skeleton from the endophytic fungus Periconia sp. Org. Lett. 2015, 17: 4304-4307.

4. Zhang Dewu, Ge Hanlin, Zou Jian-Huan, Tao Xiaoyu, Chen Ridao, Dai Jungui*. Periconianone A, a new 6/6/6 carbocyclic sesquiterpenoid from endophytic fungus Periconia sp. with anti-inflammatory activity. Org. Lett. 2014, 16: 1410-1413.

5. Zhang Dewu, Ge Hanlin, Xie Dan, Chen Ridao, Zou Jian-Hua, Tao Xiaoyu, Dai Jungui*. Periconiasins A-C, new cytotoxic cytochalasans with an unprecedented 9/6/5 tricyclic ring system from endophytic fungus Periconia sp. Org. Lett. 2013, 15: 1674-1677.

6. Zhang Dewu, Zhao Lili, Wang Lining, Fang Xiaomei, Zhao Jianyuan, Wang Xinwei, Li Li, Liu Hongyu, Wei Yuzhen, You Xuefu, Cen Shan, Yu Liyan*. Griseofulvin derivative and indole alkaloids from Penicillium griseofulvum CPCC 400528. J. Nat. Prod. 2017, 80: 371-376.

7. Zhang Dewu^#, Guo Jiamei^#, Zhang Min, Liu Xiao, Ba Mingyu, Tao Xiaoyu, Yu Liyan, Guo Ying*, Dai Jungui*. Oxazole-containing diterpenoids from cell cultures of Salvia miltiorrhiza and their anti-HIV-1 activities. J. Nat. Prod. 2017, 80: 3241-3246. (# co-first author)

8. Zhang Dewu, Tao Xiaoyu, Gu Guowei, Wang Yujia, Zhao Wenxia, Zhao Wuli, Ren Yan*, Dai Shengjun*, Yu Liyan*. Microbial transformation of neo-clerodane diterpenoid, scutebarbatine F, by Streptomyces sp. CPCC 205437. Front. Microbiol. 2021, 12, 62321.

9. Liu Jimei^#, Zhang Dewu^#, Zhang Min, Zhao Jinlian, Chen Ridao, Wang Nan, Zhang Dan, Dai Jungui*. Eremophilane sesquiterpenes from an endophytic fungus Periconia species. J. Nat. Prod. 2016, 79: 2229-2235. (# co-first author)

10. Guo Guowei, Cai Guowei, Wang Yujia, Li Li, Bai Jinglin, Zhang Tao, Cen Shan, Zhang Dewu*, Yu Liyan*. Daldispones A and B, two new cyclopentenones from Daldinia sp. CPCC 400770. J. Antibiot. 2021, 74, 215-218.

11. Zhang Dewu, Zhao Jianyuan, Wang Xinwei, Zhao Lili, Liu Hongyu, Wei Yuzhen, You Xuefu, Cen Shan, Yu Liyan*. Peniazaphilin A, a new azaphilone derivative produced by Penicillium sp. CPCC 400786. J. Antibiot. 2018, 71: 905-907.

12. Zhang Dewu, Tao Xiaoyu, Liu Jimei, Chen Ridao, Zhang Min, Li Li, Fang Xiaomei, Yu Li-Yan*, Dai Jungui*. Periconiasin G, a new cytochalasan with unprecedented 7/6/5 tricyclic ring system from the endophytic fungus Periconia sp. Tetrahedron Lett. 2016, 57: 796-799.

13. Liu Ji-Mei^#, Zhang De-Wu^#, Zhang Min, Chen Ri-Dao, Yan Zheng, Zhao Jian-Yuan, Zhao Jin-Lian, Wang Nan, Dai Jun-Gui*. Periconones B-E, new meroterpenoids from endophytic fungus Periconia sp. Chin. Chem. Lett. 2017, 28: 248-252. (# co-first author)

14. Zhang De-Wu, Tao Xiao-Yu, Liu Ji-Mei, Chen Ri-Dao, Zhang Min, Fang Xiao-Mei, Yu Li-Yan*, Dai Jun-Gui*. A new polyketide synthase-nonribosomal peptide synthetase hybrid metabolite from plant endophytic fungus Periconia sp. Chin. Chem. Lett. 2016, 27: 640-642.

15. Liu Ji-Mei^#, Zhang De-Wu^#, Du Wen-Yu, Zhang Min, Zhao Jin-Lian, Chen Ri-Dao, Xie Ke-Bo, Dai Jun-Gui*. Four new monoterpenoids from an endophytic fungus Periconia sp. F-31. J. Asian Nat. Prod. Res. 2017, 19: 541-549. (# co-first author)

16. Zhang De-Wu^#, Tao Xiao-Yu^#, Chen Ri-Dao, Yu Li-Yan, Dai Jun-Gui*. Regio-selective deglycosylation of icariin by cell suspension cultures of Glycyrrhiza uralensis and Morus alba. J. Asian Nat. Prod. Res. 2015, 17: 656-661. (# co-first author)

17. Zhang De-Wu^#, Tao Xiao-Yu^#, Yu Li-Yan, Dai Jun-Gui*. New 2-arylbenxofuran metabolite from cell cultures of Morus alba. J. Asian Nat. Prod. Res. 2015, 17: 683-688. (# co-first author)

18. Zhang De-Wu, Liu Xiao, Xie Dan, Chen Ridao, Tao Xiao-Yu, Zou Jian-Hua, Dai Jungui*. Two new diterpenoids from cell cultures of Salvia miltiorrhiza. Chem. Pharm. Bull. 2013, 61: 576-580.

19. Zhang De-Wu, Yang Yan, Yao Fang, Yu Qun-Ying, Dai Sheng-Jun*. Solalyratins A and B, new anti-inflammatory metabolites from Solanum lyratum. J. Nat. Med. 2012, 66: 362-366.

20. Zhang De-Wu, Li Gui-Hai, Yu Qun-Ying, Dai Sheng-Jun*. New anti-inflammatory 4-hydroxyisoflavans from Solanum lyratum. Chem. Pharm. Bull. 2010, 58: 840-842.

21. Zhang De-Wu, Dai Sheng-Jun, Liu Wan-Hui, Li Gui-Hai*. Chemical constituents from the vines of Pueraria lobata. Chin. J. Nat. Med. 2010, 8 (3): 196-198.