Name：WANG Yucheng

Department：Organic Chemistry

Tel: (8610)63165263

Email:wangyucheng@imb.pumc.edu.cn

Education & Research

Professor, Institute of Medicinal Biotechnology, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China Aug. 2006-Present

Ph.D., 2004

Major: Medicinal Chemistry

Peking Union Medical College & Chinese Academy of Medical Sciences

Beijing, China

Research Associate, Department of Organic Chemistry, Xuzhou Normal University, Xuzhou, Jiangsu Province, China Aug.1997-July 2006

M.S.,1991

Major: Medicinal Chemistry

Peking Union Medical College & Chinese Academy of Medical Sciences

Beijing, China

Research Scientist, R&D, Xuzhou pharmaceuticals, Xuzhou, Jiangsu Province, China. Aug. 1988-July 1997 

B.S. 1988

Major: Medicinal Chemistry

Shanghai Medical University

Research Field：Medicinal Chemistry

Research Interests：

Our research efforts are focused on antibacterial agents against multidrug resistant bacteria and metabolic diseases and discovery of drug leads and candidates.

(1) Minghua Wang¹, Guoning Zhang¹, Jianyuan Zhao¹, Ningning Cheng, Yujia Wang, Yuanhui Fu, Yanpeng Zheng, Juxian Wang, Mei Zhu, Shan Cen^*, Jinsheng He^**, Yucheng Wang^*. Synthesis and antiviral activity of a series of novel quinoline derivatives as anti-RSV or anti-IAV agents. Eur. J. Med. Chem., 2021, 113208. Doi: 10.1016/j.ejmech.2021.113208

(2) Guoning Zhang ¹, Minghua Wang ¹, Jianyuan Zhao ¹, Yujia Wang, Mei Zhu, Juxian Wang^**, Shan Cen^***, Yucheng Wang^*. Design, synthesis and in vitro anti-influenza A virus evaluation of novel quinazoline derivatives containing S-acetamide and NHacetamide moieties at C-4. Eur. J. Med. Chem., 2020, 206: 112706.

(3) Mei Zhu, Ling Ma, Huiyu Zhou, Biao Dong, Yujia Wang, Zhen Wang, Jinming Zhou, Guoning Zhang, Juxian Wang, Chen Liang, Shan Cen^**, Yucheng Wang^*. Preliminary SAR and biological evaluation of potent HIV-1 protease inhibitors with pyrimidine bases as novel P2 ligands to enhance activity against DRV-resistant HIV-1 variants. Eur. J. Med. Chem., 2020, 185: 111866.

(4) Mei Zhu¹, Ling Ma¹, Jiajia Wen, Biao Dong, Yujia Wang, Zhen Wang, Jinming Zhou, Guoning Zhang, Juxian Wang, Ying Guo, Chen Liang, Shan Cen ^**, Yucheng Wang ^*. Rational design and Structure_Activity relationship of coumarin derivatives effective on HIV-1 protease and partially on HIV-1 reverse transcriptase. Eur. J. Med. Chem., Eur. J. Med. Chem, 2020, 186: 111900.

(5) Guo-Ning Zhang ¹, Qiang Li ¹, Jianyuan Zhao, Xuandi Zhang, Zhuxin Xu, Yujia Wang, Yuanhui Fu, Qi Shan, Yanpeng Zheng, Juxian Wang, Mei Zhu, Ziqiang Li, Shan Cen **, Jinsheng He ***, Yucheng Wang *. Design and synthesis of 2-((1H-indol-3-yl)thio)-N-phenyl-acetamides as novel dual inhibitors of respiratory syncytial virus and influenza virus A. Eur. J. Med. Chem., 2020, 186: 111861.