Name：FU Haigen

Department：Organic Chemistry

Tel: (+86) 18770473850

Email: fuhaigen@imb.pumc.edu.cn

Education & Research Experience

2023/2 – Now    Professor, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences

2021/01 – 2023/01   Postdoctoral Fellow, Cornell University

2020/01 – 2020/12  Postdoctoral Fellow, Princeton University

2015/10 – 2019/09   Ph.D. in Pharmaceutical Biology, University of Groningen

2012/09 – 2015/07   M.S. in Microbial and Biochemical Pharmacy, Peking Union Medical College

2008/09 – 2012/07  B.S. in Pharmaceutical Engineering, Qingdao University of Science and Tech

Research Field

Biocatalysis, Medicinal Chemistry

Research Interests

Dr. Fu has been engaged in pushing the boundary of biocatalysis. His group is interested in discovering new enzymes or unlocking new reactivities by exploiting non-natural mechanisms with photochemical strategies to address challenges in organic synthesis. He is also interested in developing enzymatic or chemoenzymatic cascade to prepare chiral pharmaceutical molecules. In Med Chem part, he is interested in developing anti-bacterial/virus drugs.

1. H. Fu, J. Cao, T. Qiao, Y. Qi, S.J. Charnock, S. Garfinkle, T.K. Hyster*. An asymmetric sp³–sp³ cross-electrophile coupling using ‘ene’-reductases. Nature 2022, 610, 302–307.

2. H. Fu^#, J. Zhang^#, M. Saifuddin^#, G. Cruiming, P.G. Tepper, G.J. Poelarends*. Chemoenzymatic asymmetric synthesis of the metallo-β-lactamase inhibitor Aspergillomarasmine A and related aminocarboxylic acids. Nat. Catal., 2018, 1, 186–189.

3. H. Fu^#, T. Qiao^#, J.M. Carceller, S.N. MacMillan, T.K. Hyster*. Asymmetric C-alkylation of nitroalkanes via enzymatic photoredox catalysis. J. Am. Chem. Soc., 2023, 145, 787–793.

4. H. Fu, H. Lam, M. Emmanuel, J.H. Kim, B.A. Sandoval, T.K. Hyster*. Ground state electron transfer as an initiation mechanism for biocatalytic C–C bond forming reactions. J. Am. Chem. Soc., 2021, 143, 9622–9629.

5. H. Fu, A. Prats-Luján, L. Bothof, J. Zhang, P.G. Tepper, and G.J. Poelarends*. Biocatalytic asymmetric synthesis of N-aryl-functionalized amino acids and substituted pyrazolidinones. ACS Catal., 2019, 9, 7292–7299.

6. H. Fu, J. Zhang, P.G. Tepper, L. Bunch, A.A. Jensen*, and G.J. Poelarends*. Chemoenzymatic synthesis and pharmacological characterization of functionalized aspartate analogues as novel excitatory amino acid transporter inhibitors. J. Med. Chem., 2018, 61, 7741–7753.

Awards and Honors

Reaxys PhD Prize Finalist (2020)

PhD degree with the highest distinction of Cum Laude, University of Groningen (2019)