Name：YU Liyan

Department：China Pharmaceutical of Culture Collection

Tel: (8610) 63187118

Email: yly@cpcc.ac.cn

Education & Research

Education Experience

1996/09 – 1999/07: Ph.D. in microbial and biochemical pharmacy, Peking Union Medical College

1993/09 – 1996/07: M.S., in microbial and biochemical pharmacy, Peking Union Medical College (PUMC)

1987/09 – 1991/07: B.S. in Department of Microbiology, Shangdong University.

Research Experience

2007/9 to present: Professor and Director of China Pharmaceutical of Culture Collection, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences,

2002/9 to J2007/7: Associate Professor, Department of National Key laboratory for Screening New Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences,

2002/11 to 2005/01: Post-doctor, Department of Biology, Georgia State University.USA,

2000/03 to 2002/08: Assistant Professor, Department of National Key laboratory for Screening New Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences,

1998/03 to 2000/03: Visiting Scholar, Research Center for Biological Function, Kitasato Institute, Tokyo, Japan,

1996/08 to 1998/06: Assistant Professor, Department of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences,

1991/09 to 1993/08: Teaching assistant, Anhui Fuyang Normal College.

Research Field：

Microbial resource, Research & development of anti-infective drugs

Research Interests：

Research on microbial resources; Research & development of anti-infective drugs; Action Mechanism and target discovery of antimicrobial drugs; Isolation and functional development of intestinal microorganism .

Selected Publications

1. Daldispones A and B, two new cyclopentenones from Daldinia sp. CPCC 400770. Gu G, Cai G, Wang Y, Li L, Bai J, Zhang T, Cen S, Zhang D, Yu L*. J Antibiot (Tokyo). 2021 Mar;74(3):215-218.

2. New butyrolactone derivatives from the endophytic Fungus Talaromyces sp. CPCC 400783 of Reynoutria japonica Houtt. Zhang R, He W, Wang Y, Zhao J, Zhou R, Li L, He Y, Cen S, Yu L*. J Antibiot (Tokyo). 2021 Apr;74(4):225-232.

3. Saccharomycomorpha psychra n. g., n. sp., a Novel Member of Glissmonadida (Cercozoa) Isolated from Arctic and Antarctica. Feng JJ, He CY, Jiang SH, Zhang T, Yu LY*. J Eukaryot Microbiol. 2021 Jan 14:e12840.

4. Development of a New Bioprocess for Clean Diosgenin Production through Submerged Fermentation of an Endophytic Fungus. Liu W, Xiang H, Zhang T, Pang X, Su J, Liu H, Ma B, Yu L*. ACS Omega. 2021 Mar 31;6(14):9537-9548.

5. Screening and Selection of a New Medium for Diosgenin Production via Microbial Biocatalysis of Fusarium sp. Liu W, Xiang H, Zhang T, Pang X, Su J, Liu H, Ma B, Yu L*. Pharmaceuticals (Basel). 2021 Apr 21;14(5):390.

6. Microbial Transformation of neo-Clerodane Diterpenoid, Scutebarbatine F, by Streptomyces sp. CPCC 205437. Zhang D, Tao X, Gu G, Wang Y, Zhao W, Zhao W, Ren Y, Dai S, Yu L*. Front Microbiol. 2021 Apr 14;12:662321.

7. Anemarrhena asphodeloides modulates gut microbiota and restores pancreatic function in diabetic rats. Yan D.,Fan P.C.,Sun W.L., Ding Q.Z., Zheng W.,Xiao W.D., Zhang B.W., Zhang T., Zhang T., Shi J.H., Chen X.J., Chen P.R., Zhang J., Hao Y., Sun X.G., Pang X., Dong Y.S*., Xu P*., Yu L.Y*., Ma B.P. *Biomedicine & Pharmacotherapy, 2021, 133:110954.

8. Soil fungal community composition differs significantly among the Antarctic, Arctic, and Tibetan Plateau. Zhang, T.,Wang, N.F., Yu, L.Y. * Extremophiles, 2020, 24: 821-829.

9. Development of a New High-Cell Density Fermentation Strategy for Enhanced Production of a Fungus-Glucosidase in Pichia pastoris. Liu W, Xiang H, Zhang T, Pang X, Su J, Liu H, Ma B and Yu L*.Front. Microbiol, 2020, 11:1988.

10. Ornithinimicrobium cerasi sp. nov., isolated from the fruit of Cerasus pseudocerasus and emended description of the genus Ornithinimicrobium. Fang XM, Du HJ, Bai JL, He WN, Li J, Wang H, Su J, Liu HY, Zhang YQ, Yu LY*. Int J Syst Evol Microbiol. 2020 Mar; 70(3):1691-1697.

11. Fed-batch high-cell-density fermentation strategies for Pichia pastoris growth and production.Liu WC, Inwood S, Gong T, Sharma A, Yu LY*, Zhu P*.Crit Rev Biotechnol. 2019 Mar; 39(2): 258-271. IF=7.054(综述)；

12. Bacterial community pattern along the sediment seafloor of the Arctic fjorden (Kongsfjorden, Svalbard). Fang XM, Zhang T, Li J, Wang NF, Wang Z, Yu LY*. Antonie Van Leeuwenhoek. 2019 Aug;112(8):1121-1136.

13. GKK1032C, a new alkaloid compound from the endophytic fungus Penicillium sp. CPCC 400817 with activity against methicillin-resistant S. aureus. Qi X, Li X, Zhao J, He N, Li Y, Zhang T, Wang S, Yu L*, Xie Y*. J Antibiot (Tokyo). 2019 Apr;72(4):237-240.

14. Design, synthesis, and bioevaluation of a novel class of (E)-4-oxo-crotonamide derivatives as potent antituberculosis agents. Ren J, Xu J, Zhang G, Xu C, Zhao L, You X, Wang Y, Lu Y, Yu L*, Wang J*. Bioorg Med Chem Lett. 2019 Feb 15;29(4):539-543.

15. Isolation of endophytic fungi from Dioscorea zingiberensis C. H. Wrightand application for diosgenin production by solidstate fermentation. Haibo Xiang，Tao Zhang，Xu Pang，Yuzhen Wei ，Hongyu Liu， Yuqin Zhang，Baiping Ma，Liyan Yu*.Appl Microbiol Biotechnol. 2018 Jul; 102(13):5519-5532.

16. Roseomonas globiformis sp. nov., an airborne bacteria isolated from an urban area of Beijing. Fang XM, Bai JL, Zhang DW, Su J, Zhao LL, Liu HY, Zhang YQ, Yu LY*. Int J Syst Evol Microbiol. 2018 Oct;68(10):3301-3306

17. Glycomyces paridis sp. nov., isolated from the medicinal plant Paris polyphylla. Fang XM, Bai JL, Su J, Zhao LL, Liu HY, Ma BP, Zhang YQ, Yu LY*. Int J Syst Evol Microbiol. 2018 May;68(5):1578-1583.

18. Structural Variation in the Bacterial Community Associated with Airborne Particulate Matter in Beijing, China, during Hazy and Nonhazy Days. Yan D, Zhang T, Su J, Zhao LL, Wang H, Fang XM, Zhang YQ, Liu HY, Yu LY*.Appl Environ Microbiol. 2018 Apr 16;84(9). pii: e00004-18.

19. Peniazaphilin A, a new azaphilone derivative produced by Penicillium sp. CPCC 400786. Zhang D, Zhao J, Wang X, Zhao L, Liu H, Wei Y, You X, Cen S, Yu L*. J Antibiot (Tokyo). 2018 Oct;71(10):905-907.

20. Griseofulvin Derivative and Indole Alkaloids from Penicillium griseofulvum CPCC 400528. Zhang D, Zhao L, Wang L, Fang X, Zhao J, Wang X, Li L, Liu H, Wei Y, You X, Cen S, Yu L*. J Nat Prod. 2017 Feb 24;80(2):371-376.

21. Metabolites from the Plant Endophytic Fungus Aspergillus sp. CPCC 400735 and Their Anti-HIV Activities. Pang X, Zhao JY, Fang XM, Zhang T, Zhang DW, Liu HY, Su J, Cen S, Yu LY*. J Nat Prod. 2017 Oct 27;80(10):2595-2601.

22. Ornithinimicrobium flavum sp. nov., isolated from the leaf of Paris polyphylla. Fang XM, Yan D, Bai JL, Su J, Liu HY, Ma BP, Zhang YQ, Yu LY*.Int J Syst Evol Microbiol. 2017 Nov;67(11):4541-4545.

23. A novel protein kinase inhibitor IMB-YH-8 with anti-tuberculosis activity. Sci Rep. Xu J, Wang JX, Zhou JM, Xu CL, Huang B, Xing Y, Wang B, Luo R, Wang YC, You XF, Lu Y, Yu LY*. 2017 Jul 11;7(1):5093. doi: 10.1038/s41598-017-04108-7

24. Paenibacillus eucommiae sp. nov., isolated from a traditional Chinese medicinal herbal plant, Eucommia ulmoides Oliver. Fang XM, Su J, Wang H, Zhang T, Zhao LL, Liu HY, Ma BP, Zhang YQ, Yu LY*. Int J Syst Evol Microbiol. 2017 Apr;67(4):993-997.

25. Surfactin derivatives from Micromonospora sp. CPCC 202787 and their anti-HIV activities. Pang X, Zhao J, Fang X, Liu H, Zhang Y, Cen S, Yu L*. J Antibiot (Tokyo). 2017 Jan;70(1):105-108.

26. Diversity and distribution of cultured endolichenic fungi in the Ny-Ålesund Region, Svalbard (High Arctic). Zhang T, Wei XL, Wei YZ, Liu HY, Yu LY*. Extremophiles. 2016 Jul; 20(4):461-70.

27. Diversity and Composition of Airborne Fungal Community Associated with Particulate Matters in Beijing during Haze and Non-haze Days. Yan D, Zhang T, Su J, Zhao LL, Wang H, Fang XM, Zhang YQ, Liu HY, Yu LY*. Front Microbiol. 2016 Apr 14; 7:487.

28. Soil pH is a Key Determinant of Soil Fungal Community Composition in the Ny-Ålesund Region, Svalbard (High Arctic). Zhang T, Wang NF, Liu HY, Zhang YQ, Yu LY*.Front Microbiol. 2016 Feb 26;7:227.

29. Diversity and Distribution of Aquatic Fungal Communities in the Ny-Ålesund Region, Svalbard (High Arctic): Aquatic Fungi in the Arctic. Zhang T, Wang NF, Zhang YQ, Liu HY, Yu LY*. Microb Ecol. 2016 Apr;71(3):543-54.

30. Periconiasin G, a new cytochalasan with unprecedented 7/6/5 tricyclic ring system from the endophytic fungus Periconia sp.，Dewu Zhang, Xiaoyu Tao, Jimei Liu, Ridao Chen, Min Zhang, Li Li, Xiaomei Fang, Yu LY*, Jungui Dai* .Tetrahedron Letters, 2016, 57(7) :796-799

31. A new polyketide synthase nonribosomal peptide synthetase hybrid metabolite from plant endophytic fungus Periconia sp. De-Wu Zhang, Xiao-Yu Tao, Ji-Mei Liu, Ri-Dao Chen, Min Zhang, Xiao-Mei Fang, Li-Yan Yu,*, Jun-Gui Dai*. Chinese Chemical Letters, 2016, 47(5):640-642

32. Diversity and distribution of fungal communities in the marine sediments of Kongsfjorden, Svalbard (High Arctic). Zhang T, Wang NF, Zhang YQ, Liu HY, Yu LY*. Sci Rep. 2015 Oct 23;5:14524.

33. Diversity and distribution of lichen-associated fungi in the Ny-Ålesund Region (Svalbard, High Arctic) as revealed by 454 pyrosequencing. Zhang T, Wei XL, Zhang YQ, Liu HY, Yu LY*.Sci Rep. 2015 Oct 14;5:14850.

Awards and Honors

New Century Excellent Talents in University of Ministry of Education of China

Xihe Scholar

Academic Appointments

Vice director, Committee of Microbial Resources, Chinese Society for Microbiology

Chairman of Enzyme Engineering and Fermentation Engineering Committee，China Medicinal Biotech Association

Member of the 7th Academic Committee of Chinese Academy of Medical Sciences/Peking Union Medical College

Editorial board member of Microbiology China, Chinese Journal of Antibiotics, Chinese Medicinal Biotechnology