Name：YANG Zhaoyong

Department：Microbiology Metabolic Engineering

Tel: (8610)63165283

Email:zhaoyongy@imb.pumc.edu.cn

Education & Research Experience

2011.09-Present: Professor, Peking Union Medical College

2008.02-2011.05: Post-doc., University of Kentucky

2004.09-2007.06: Ph.D. in microbial and biochemical pharmacy, Peking Union Medical College

Research Field：

Structural Biology; Computational Chemistry

Research Interests：

Our lab had three major objectives: (1) exploring the catalytic mechanism key enzymes in natural product biosyntheses by MD and QM/MM calculations; (2) undergoing the structural biology research on bio-macromolecules, based on X-ray crystallography. The structural study on our drug-targeted bio-macromolecules will further contribute to the computer-aided drug design research on anti-infective drug leads in my group; (3) activity and pharmaceutical properties of small molecule natural peptide.

established experimental facility including the fermentation systems will be a solid resource to perform large-scale screenings on the purpose of discovering anti-TB lead compounds.

Dr. Wang has been engaged in the systematics and evolution of insects. On the basis of inheriting the traditional taxonomy, he has opened up a new research direction of the new taxonomy driven by new technologies such as quantification, Big Data and Artificial Intelligence……..

Selected Publications

1. Ying Huang, Xiaodong Liu, Zheng Cui, Daniel Wiegmann, Giuliana Niro, Christian Ducho, Yuan Song, Zhaoyong Yang* and Steven G. Van Lanen*, Pyridoxal-5′-phosphate as an oxygenase cofactor: Discovery of a carboxamide-forming, α-amino acid monooxygenase-decarboxylase[J]. Proceedings of the National Academy of Sciences, 2018: 201718667.

2. Masanori Funabashi^#, Zhaoyong Yang^#, Koichi Nnonaka1*, Masahiko Hosobuchi, Yoko Fujita, Ttomoyuki Sshibata, Xiuling Chi, Ssteven G Van Lanen*, An ATP-independent strategy for amide bond formation in antibiotic biosynthesis[J]. Nature chemical biology, 2010, 6(8): 581.

3. Ka Lu^#, Xiao Feng^#, ChaoXian Yan, FangLing Yang, Xing Yang, PanPan Zhou* and Zhaoyong Yang*, Chiral phosphoric acid catalyzed asymmetric arylation of indoles via nucleophilic aromatic substitution: mechanisms and origin of enantioselectivity [J]. Catalysis Science & Technology, (2020) 10, 2277.

4. Quanjie Li^#, Shuai Fan^#, Xiaoyu Li, Yuanyuan Jin, Weiqing He, Jinming Zhou*, Shan Cen*, Zhaoyong Yang*, Insights into the Phosphoryl Transfer Mechanism of Human Ubiquitous Mitochondrial Creatine Kinase, Scientific reports, 2016, 6: 38088

5. Zhaoyong Yang^#, Masanori Funabashi^#, Koichi Nonaka*, Masahiko Hosobuchi, Tomoyuki Shibata, Pallab Pahari, and Steven G. Van Lanen*, Functional and kinetic analysis of the phosphotransferase CapP conferring selective self-resistance to capuramycin antibiotics[J]. Journal of Biological Chemistry, 2010, 285(17): 12899-12905.