Name：Guangzhi Shan

Department：Analysis and Testing Center

Tel: (8610)67019851

Email: shanguangzhi@imb.pumc.edu.cn

Education & Research Experience

2010/09-Now: Associate Professor, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences

2002/09-2010/07: Chinese Academy of Medical Sciences, Institute of Medicinal Biotechnology, Degree: Doctor & Master

1994/09-1999/07: Yantai University, Degree: Bachelor

Research Field：

Pharmaceutical analysis：Development of analytical methods for biological drugs; Impurity identification

Fragment-Based Drug Design: SPR, NMR, WAC, ITC, X-Ray

Research Interests：

Dr. Shan has been conducting research on drug discovery, especially the screening and design of antibacterial drugs; has participated in a number of fund projects related to drug discovery, such as National Major Scientific and Technological Special Project and National Natural Science Foundation of China; has also been engaging in the development of detection methods and technologies for biological drugs, as well as the identification of their impurity profiles.

Selected Publications

1. Xiaodan Qiu, Limin Zuo, Shengnan Sun, Xuejia Zhao, Shijie Xu, Zhiling Zhu, Ting Zhao, Zhonghao Sun, Jing Yao^*, Guangzhi Shan^*, Impurity profiling of Compound Amino Acid Injection (6AA) using ion-pair high performance liquid chromatography coupled with corona-charged aerosol detection and high resolution mass spectrometry. Journal of pharmaceutical and biomedical analysis, 2021,114099.

2. Kewei Sunn^‡, Zhonghao Sun^‡, Fenglan Zhao, Guangzhi Shan^*, Qingguo Men^*. Recent Advance in Research of Colchicine Binding Site Inhibitors and Their Interaction Modes with Tubulin. Future Medicinal Chemistry, online, 10.4155/fmc-2020-0376.

3. Zhiling Zhu¹, Xiaodan Qiu¹, Shuo Wu¹, Yitong Liu, Ting Zhao, Zhonghao Sun, Zhuorong Li^*, Guangzhi Shan^*. Blocking Effect of Demethylzeylasteral on the Interaction between Human ACE2 Protein and SARS-CoV-2 RBD Protein Discovered Using SPR Technology, Molecules, 12(2020)57-60.4.

4. Shuo Zhang¹, Xiaodan Qiu^1, Ran Wang, Lianqi Sun, Zhiling Zhu, Guangzhi Shan^**, Zhuorong Li*. Discovery of indolyl-containing peptides as novel antibacterial agents targeting on tryptophanyl-tRNA synthetase, Future Medicinal Chemistry, (2020) 12 (10): 877-896.

5. Yajun Bai¹, Xirui He¹, Yujun Bai, Ying Sun, Zefeng Zhao, Xufei Chen, Bin Li, Jing Xie, Yang Li, Pu Jia, Xue Meng, Ye Zhao, Yanrui Ding, Chaoni Xiao, Shixiang Wang, Jie Yu, Sha Liao, Yajun Zhang, Zhiling Zhu, Qiang Zhang, Yuhui Zhao, Fanggang Qin, Yi Zhang, Xiaoyang Wei, Min Zeng, Jing Liang, Ye Cuan, Guangzhi Shan^***, Tai-Ping Fan^**, Biao Wu, Xiaohui Zheng^*. Polygala tenuifolia-Acori tatarinowii herbal pair as an inspiration for substituted cinnamic a-asaronol esters: Design, synthesis, anticonvulsant activity, and inhibition of lactate dehydrogenase study. European Journal of Medicinal Chemistry. (2019) 183: 111650.

6. Zhiling Zhu, Mengxue Feng, Limin Zuo, Jinghua Li, Guangzhi Shan^*, Shi-Zhong Luo^*. An aptamer based surface plasmon resonance biosensor for the detection of ochratoxin A in wine and peanut oil. Biosensors and Bioelectronics, (2015). 65: 320-326.

7. Wei Sun, Limin Zuo, Ting Zhao, Zhiling Zhu, Guangzhi Shan^*. Five solvates of a multicomponent pharmaceutical salt formed by berberine and diclofenac. Acta Cryst. (2019). C75, 1644–1651.

8. Ran Wang¹, Zhiling Zhu¹, Xiaodan Qiu, Liping Bai, Weiwei Guo, Limin Zuo, Ting Zhao, Guangzhi Shan*. Determination of epoxide impurity in sarpogrelate hydrochloride intermediate by UHPLC and column-switching liquid chromatography, Journal of Pharmaceutical and Biomedical Analysis, (2019)174: 57-62.

9. Panpan Li, Wei Sun, Limin Zuo, Zhiling Zhu, Ting Zhao, Ran Wang, Minghui Zhu, Xiaoyun Leng, Xiaodan Qiu, Liping Bai, Guangzhi Shan^*. Fast simultaneous determination of main components and impurity sodium ion in PAMA injection by mixed-mode chromatography, Journal of Pharmaceutical and Biomedical Analysis, (2018)161: 407-413.

10. Wenbo Wu, Zhiling Zhu, Bingjie Li, Zhuqing Liu, Lili Jia, Limin Zuo, Long Chen, Zhentai Zhu, Guangzhi Shan^**, Shi-Zhong Luo^*. A direct determination of AFBs in vinegar by aptamer-based surface plasmon resonance biosensor. Toxicon,(2018) 146, 24-30.

11. Wei Sun, Li-Min Zuo, Ting Zhao, Zhi-Ling Zhu, Yong-Hua Liu, Guang-Zhi Shan^*. Crystal structure of N-(4-chlorophenyl)-2-(2,6-dichlorophenyl)acetamide, C14H10Cl3NO, Zeitschrift fr Kristallographie-New Crystal Structures. 2018, 233(5):913-914.

12. Wei Sun, Zhi-Ling Zhu, Li-Min Zuo, Ting Zhao, Ming-Hui Zhu, Guang-Zhi Shan^*. Crystal structure of tert-butyl (R)-(1-(benzylamino)-3-methoxy-1-oxopropan-2-yl) carbamate, C16H24N2O4. Zeitschrift fr Kristallographie-New Crystal Structures. 2018, 234(1):119-120.

13. Mengxue Feng, Zhiling Zhu, Limin Zuo, Long Chen, Qipeng Yuan, Guangzhi Shan^*, Shi-Zhong Luo^*. A strategy for rapid structural characterization of saponins and flavonoids from the testa of Camellia oleifera Abel seeds by ultra-high-pressure liquid chromatography combined with electrospray ionization linear ion trap-orbitrap mass spectrometry. Analytical methods, (2015), 7(14): 5942-5953.

14. Wei Sun, Yanping Li, Jie Jin, Zhuorong Li, Guangzhi Shan^*. Crystal structure of 17-(2 '-(1'-oxa-4'-aza-heterocyclohexyl-1'-)ethylamino)-17-demethoxygeldanamycin dihydrate, C34H54N4O11. Zeitschrift fr Kristallographie-New Crystal Structures, (2015).6 230(2): 180-182

15. Yanping Li ; Linyan Gao ; Kaitong Li; Shuai Meng; Jianhua Zhu; Dong Li; Jie Jin; Guangzhi Shan^*, Zhuorong Li^*. LC–MS/MS method for determination of geldanamycin derivative GM-AMPL in rat plasma to support preclinical development. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, (2013), 1, 912, 43-49.

16. Guangzhi Shan¹, Zonggen Peng¹, Yuhuan Li, Dong Li, Yanping Li, Shuai Meng, Linyan Gao, Jiandong Jiang* and Zhuorong Li*. A novel class of geldanamycin analogues as HCV replication inhibitors targeting on Hsp90: synthesis, structure-activity relationships, and anti HCV activity in GS4.3 replicon cells. Journal of Antibiotics ,(2011) 64: 177-182

17. Yanping Li¹, Guangzhi Shan¹, Zonggen Peng1, Jianhua Zhu, Shuai Meng, Tian Zhang, Lin-yan Gao, Peizhen Tao, Rongmei Gao, Yuhuan Li*, Jiandong Jiang* and Zhuorong Li*. Synthesis and biological evaluation of heat-shock protein 90 inhibitors geldanamycin derivatives with broad antiviral activities Antiviral Chemistry & Chemotherapy 2010, 20: 259-268.

Academic Appointments

Supervisory Research Expert Committee on Generic Drug Consistency of China Society for Drug Regulation, Commissioner

Medical Modernization and Clinical Professional Committee of China Ethnic Medical Association, Director

Expert Committee of China Biochemical Pharmaceutical Industry Association, Commissioner

Pharmaceutical Chemistry Professional Committee of Beijing Pharmaceutical Association, Commissioner

Chinese Journal of Antibiotics，Youth member of the Editorial Board