Name：Mingliang Liu

Department: Department of Chemistry

Tel: (8610)63036965

Email: liumingliang@imb.pumc.edu.cn

Research Experience

2011/09 – Now Professor, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences

2004/09 – 2011/08 Associate Professor, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences

1996/08 – 2004/08 Assistant Professor, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences

1994/07-1996/07 Teacher, No. 2 middle School of Miyun, Beijing

1984/07-1994/06 Teacher, No. 13 middle School of Xining, Qinghai

Education

2000/09 - 2003/07 Master in Microbial and Biochemical Pharmacy, Peking Union Medical College

1980/09 – 1984/07 Bachelor in Chemistry, Shaanxi Normal University

Research Field：

Anti-infections; Anti-tumor; Drug Discovery

Research Interests：

Our group has focused on the discovery of new candidates through design, synthesis, and SAR research of novel compounds with anti-infection (anti-virus, anti-TB, anti-bacterial) or anti-tumor activity. Antibacterial candidate IMB-031124 gained Phase II clinical approval, and the pre-clinical study of another IMB-070593 has been nearly completed.

Recent Publications：

1. Apeng Wang, Shijie Xu, Yun Chai, Guimin Xia, Bin Wang, Kai Lv, Chao Ma, Dan Wang, Aoyu Wang, Xiaoyu Qin, Mingliang Liu, Yu Lu. Design, synthesis and biological activity of N-(amino)piperazine-containing benzothiazinones against Mycobacterium tuberculosis. Eur. J. Med. Chem., 2021, 218：113398

2. Zhanying Hu, Haiqun Ban, Haiyan Zheng, Mingliang Liu, Jinhong Chang, Jutao Guo. Protein phosphatase 1 catalyzes HBV core protein dephosphorylation and is co-packaged with viral pregenomic RNA into nucleocapsids. PLoS Pathog, 2020,16(7): e1008669

3. Apeng Wang, Yu Lu, Kai Lv, Chao Ma, Shijie Xu, Bin Wang, Yun Chai, Guimin Xia, Mingliang Liu. Design, synthesis and antimycobacterial activity of new benzothiazinones inspired by rifampicin / rifapentine. Bioorg. Chem., 2020, 94: 103363

4. Shaochen Guo, Lei Fu, Bin Wang, Xi Chen, Jiaojie Zhao, Mingliang Liu, Lu, Y. In vitro and in vivo antimicrobial activities of a novel piperazine-containing benzothiazinones candidate TZY-5-84 against Mycobacterium tuberculosis. Biopha, 2020，131：110777

5. Apeng Wang, Chao Ma, Yun Chai, Xiujun Liu, Kai Lv, Lei Fu, Bin Wang, Mingliang Liu, Yu Lu. Identification of benzothiazinones containing 2-benzyl-2,7-diazaspiro[3.5]nonane moieties as new antitubercular agents. Eur. J. Med. Chem., 2020, 200:112409

6. Kai Lv, Wenyan Li, Shuo Wu, Yunhe Geng, Apeng Wang, Lu Yang, Menghao Huang, Kushan Chowdhury, Yuhuan Li, Mingliang Liu. Amino acid prodrugs of NVR3-778: design, synthesis and anti-HBV activity. Bioorg Med Chem Lett, 2020, 30: 127103

7. Linhu Li, Apeng Wang, Bin Wang, Mingliang Liu, Kai Lv, Zeyu Tao, Chao Ma, Xican Ma, Bing Han, Aoyu Wang, Yu Lu. N-(2-Phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamides containing various amine moieties: design, synthesis and antitubercular activity. Chin Chem Lett, 2020, 31: 409–412

8. Kai Lv, Shuo Wu, Wenyan Li, Yunhe Geng, Meng Wu, Jinming Zhou, Yuhuan Li, Qiang Gao, Mingliang Liu. Design, synthesis and anti-HBV activity of NVR3-778 derivatives. Bioorg.Chem., 2020, 94: 103363

9. Hua Jin, Ting Zhu, Xiange Huang, Mo Sun, Hegen Li, Xinyuan Zhu, Mingliang Liu, Yibin Xie,Wei Huang, Deyue Yan. ROS-responsive nanoparticles based on amphiphilic hyperbranched polyphosphoester for drug delivery: Light-triggered size-reducing and enhanced tumor penetration. Biomaterials. 2019, 211: 68-80.

10. Apeng Wang, Kai Lv, Zeyu Tao, Jian Gu, Lei Fu, Mingliang Liu, Baojie Wand, Scott G. Franzblau, Chao Ma, Xican Ma, Bing Han, Aoyu Wang, Shijie Xu, Yu Lu. Identification of Benzothiazinones Containing an Oxime Functional Moiety as New Anti-tuberculosis Agents. Eur. J. Med. Chem., 2019, 181: 111595

11. Apeng Wang, Kai Lv, Linhu Li, Hongtao Liu, Zeyu Tao, Bin Wang, Mingliang Liu, Chao Ma, Xican Ma, Bing Han, Yu Lu. Design, synthesis and biological activity of N-(2-phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamides as new antitubercular agents. Eur. J. Med. Chem., 2019,175: 715-725

12. Kai Lv, Apeng Wang, Zeyu Tao, Hongtao Liu, Lei Fu, Bin Wang, Chao Ma, Hongjian Wang, Xican Ma, Bing Han, Auyu Wang, Kai Zhang, Mingliang Liu, Yu Lu. hERG optimizations of IMB1603, discovery of alternative Benzothiazinone candidates as new antitubercular agents. Eur. J. Med. Chem., 2019,179: 208-217

13. Apeng Wang, Shuo Wu, Zeyu Tao, Xiaoning Li, Kai Lv, Chao Ma, Yuhuan Li, Linhu Li, Mingliang Liu. Design, synthesis and anti-HBV activity of new bis(L-amino acid) ester tenofovir prodrugs. ACS Med. Chem. Lett., 2019, 10: 991-995

14. Meng Wu, Yongli Xie, Xiangling Cui, Chenchao Huang, Rongyu Zhang, Yang He, Xiaoyu Li, Mingliang Liu, Shan Cen, Jinming Zhou. Rational drug design for androgen receptor and glucocorticoids receptor dual antagonist. Eur. J. Med. Chem., 2019, 166：232-242

15. Hongjian Wang, Apeng Wang, Jian Gu, Fu Lei, Yun Chai, Kai Lv, Chao Ma, Zeyu Tao, Bin Wang, Mingliang Liu, Huiyuan Guo, Yu Lu. Design, synthesis and antimycobacterial activity of less lipophilic imidazo[1,2-a]pyridine-3-carboxamide derivatives as new antitubercular agents. Eur. J. Med. Chem., 2019, 165：11-17

16. Hongjian Wang, Kai Lv, Apeng Wang, Bin Wang, Zeyu Tao, Mingliang Liu, Huiyuan Guo, Yu Lu. Design, synthesis and antimycobacterial activity of novel nitrobenzamide derivatives. Chin. Chem. Lett., 2019, 30：413-416

17. Apeng Wang, Hongjian Wang, Yunhe Geng, Bin Wang, Kai Lv, Mingliang Liu, Zeyu Tao, Huiyuan Guo, Yu Lu. Design, synthesis and antimycobacterial activity of Q203 derivatives containing alkaline fused ring moieties. Bioorg. Med. Chem., 2019, 27：813-821

18. Yangguang Liu, Meng Wu, Tianqi Wang, Yongli Xie, Xiangling Cui, Liujun He, Yang He, Xiaoyu Li, Mingliang Liu, Laixing Hu, Shan Cen and Jinming Zhou. Structural Based Screening of Antiandrogen Targeting Activation Function-2 Binding Site. Front Pharmacol, 2018, 9:1419

19. Qing-Cheng Ren, Chuan Gao, Zhi Xu, Lian-Shun Feng, Ming-liang Liu, Xiang Wu, Feng Zhao. Bis-coumarin Derivatives and Their Biological Activities. Curr. Top Med. Chem., 2018, 18(2): 101-113

20. Dan Jiang, Gang-Qiang Wang, Xiaofeng Liu, Zhenbin Zhang, Lian-Shun Feng, Ming-Liang Liu. Isatin Derivatives with Potential Antitubercular Activities. J. Heterocyclic Chem., 2018, 55, 1263-1279

21. Guo-Cheng Huang, Yan Xu, Zhi Xu, Zao-Sheng Lv, Jun Zhang, Hui-Yuan Guo, Yuan-Qiang Hu, Ming-Liang Liu, Jian-Guo Guan, Lu Yu. Propylene-1H-1,2,3-triazole-4-methylene-tethered Isatin-coumarin Hybrids: Design, Synthesis, and In Vitro Anti-tubercular Evaluation. J. Heterocyclic. Chem., 2018, 55, 830-835

22. Zeyu Tao, Ruiyuan Cao, Yunzheng Yan, Guocheng Huang, Kai Lv, Wei Li, Yunhe Geng, Lei Zhao, Apeng Wang, Qinghao He, Jingjing Yang, Shiyong Fan, Menghao Huang, Huiyuan Guo, Wu Zhong, Mingliang Liu. Design, Synthesis and in vitro Anti-Zika virus evaluation of novel Sinefungin derivatives. Eur. J. Med. Chem., 2018, 157：994-1004.

23. Yang Gao, Lu-Xin Na, Zhi Xu, Lian-Shun Feng, A-Peng Wang, Kai Lv, Hui-yuan Guo, Ming-Liang Liu. Design, Synthesis and Antibacterial Evaluation of 1-[(1R, 2S)-2-Fluorocyclopropyl] ciprofloxacin-1,2,4-triazole-5(4H)-thione Hybrids. Chem Biodiv，2018, e1800261

24. Apeng Wang Guocheng Huang, Bin Wang, Kai Lv, Hongjian Wang, Zeyu Tao, Mingliang Liu, Huiyuan Guo, Yu Lu. Design, synthesis and antimycobacterial activity of 3,5-dinitrobenzamide derivatives containing fused ring moieties. Bioorg. Med. Chem. Lett.，2018, 28: 2945-2948

25. Linhu Li, Kai Lv, Genhua Chen, Apeng Wang, Bin Wang, Mingliang Liu, Huiyuan Guo, Yu Lu. Identification of N-benzyl 3,5-dinitrobenzamides as New Antitubercular Agents. ACS Med. Chem. Lett., 2018, 9:741-745

Apeng Wang, Wenyan Li, Bin Wang, Kai Lv, Hongjian Wang, Mingliang Liu, Huiyuan Guo, Yu Lu. Design, synthesis and evaluation of nitrofuranyl methyl N-heterocycles derivatives as novel antitubercular agents. Future Med. Chem., 2018, 10 (17): 2059-2068

26. Kai Lv, Zeyu Tao, Qian Liu, Lu Yang, Bin Wang, Shuo Wu, Apeng Wang, Mingliang Liang Liu, Yu Lu. Design, synthesis and antitubercular evaluation of benzothiazinones containing a piperidine moiety. Eur. J. Med. Chem., 2018, 151：1-8

27. Apeng Wang, Yang Yang, Genhua Chen, Bin Wang, Kai Lv, Mingliang Liu, Huiyuan Guo, Yu Lu. Nitrofuranyl Methyl derivatives as novel antitubercular agents. Bioorg. Med. Chem., 2018, 26: 2073-2084.

Gui-Fu Zhang, Xiaofeng Liu, Shu Zhang, Baofeng Pan, Ming-Liang Liu. Ciprofloxacin derivatives and their antibacterial activities. Eur. J. Med. Chem., 2018, 146: 599-612