Name：XIE Yunying

Department：Department of Microbial Chemistry

Tel: (8610) 63165276

Email:xieyy@imb.pumc.edu.cn

Education & Research Experience

2011/11 – Now Associate Professor, Institute of Medicinal Biotechnology, Chinese Academy of Medical Science

2017/07 – 2017/09 Visiting Academic, Institute for Molecular Bioscience, The University of Queensland, St. Lucia QLD 4072, Australia.

2007/09 – 2011/10 Assistant Professor, Institute of Medicinal Biotechnology, Chinese Academy of Medical Science

2002/09 – 2007/08 Ph.D. in microbial and biochemical pharmacy, Peking Union Medical College

1998/09 – 2002/07 Bachelor of Science, School of Pharmaceutical Sciences, Shandong University, Shandong, P. R. China.

Research Field：

The discovery of microbial drugs against infection, tumor and hyperlipemia

Research Interests：

Dr. Xie has been engaged in the discovery of microbial drugs, especially those against infection, tumor and hyperlipemia: On the basis of traditional bioassay-guided method, she has established a more efficient platform for the discovery of new leading compounds by the combination of new technologies such as genome sequencing, bioinformatics, synthetic biology and metabolomics.

Selected Publications

1. Li Y, He N, Luo M, Hong B*, Xie Y*. Application of Untargeted Tandem Mass Spectrometry with Molecular Networking for Detection of Enniatins and Beauvericins from Complex Samples. Journal of Chromatography A 2020: 461626

2. Li,Y.; Liu, L.; Zhang, G.; He, N.; Guo, W.; Hong, B.; Xie, Y.*,Potashchelins, a Suite of Lipid Siderophores Bearing Both L-threo and L-erythroBeta-Hydroxyaspartic Acids, Acquired From the Potash-Salt-Ore-Derived ExtremophileHalomonas sp. MG34. Frontiers inChemistry 2020, 8.

3. Shi, Y.; Gu, R.; Li, Y.; Wang,X.; Ren, W.; Li, X.; Wang, L.; Xie, Y. *; Hong, B. *, Exploring novelherbicidin analogues by transcriptional regulator overexpression and MS/MSmolecular networking. Microb Cell Fact 2019, 18, 175.

4. Shi, Y.; Wang, X.; He, N.; Xie,Y. *; Hong, B. *, Rescrutiny of the sansanmycin biosynthetic gene cluster leads tothe discovery of a novel sansanmycin analogue with more potency againstMycobacterium tuberculosis. J Antibiot(Tokyo) 2019, 72, 769-774.

5.  Qi, X.; Li, X.; Zhao, J.; He,N.; Li, Y.; Zhang, T.; Wang, S.; Yu, L. *; Xie, Y. *, GKK1032C, a newalkaloid compound from the endophytic fungus Penicillium sp. CPCC 400817 withactivity against methicillin-resistant S. aureus. J Antibiot (Tokyo) 2019,72, 237-240.

6.  Jiang, Z. B.; Ren, W. C.; Shi,Y. Y.; Li, X. X.; Lei, X.; Fan, J. H.; Zhang, C.; Gu, R. J.; Wang, L. F.; Xie,Y. Y.*; Hong, B.*, Structure-based manual screening and automaticnetworking for systematically exploring sansanmycin analogues using highperformance liquid chromatography tandem mass spectroscopy. J Pharm BiomedAnal 2018, 158, 94-105.

7. Qi,X.; Wang, X.; Ren, H.; Zhang, F.; Zhang, X.; He, N.; Guo, W.; Chen, R.; Xie, Y.*; He, Q.*, NC1404, a novelderivative of Bleomycin with modified sugar moiety obtained during thepreparation of Boningmycin. J Antibiot(Tokyo) 2017, 70, 970-973.

8. Wang, S.; Zhang, N.; He, N.; Guo, W.; Lei, X.; Cai, Q.; Hong,B.; Xie, Y. *, Exploiting SubstrateDiversity of NRPS led to the generation of new sansanmycin analogs. Nat Prod Commun 2017,12(5),781-783.

9. Zhang, N.;Liu, L.; Shan, G.; Cai, Q.; Lei, X.; Hong, B.; Wu, L.; Xie, Y.*; Chen, R.*, Precursor-directed biosynthesis of newsansanmycin analogs bearing para-substituted-phenylalanines with high yields. J Antibiot (Tokyo) 2016, 69, (10), 765-768.

10.  Shi, Y.;Jiang, Z.; Lei, X.; Zhang, N.; Cai, Q.; Li, Q.; Wang, L.; Si, S.; Xie, Y.*; Hong, B.*, Improving theN-terminal diversity of sansanmycin through mutasynthesis. Microb Cell Fact 2016,15, (1), 77.

11. Xie, Y.; Cai, Q.;Ren, H.; Wang, L.; Xu, H.; Hong, B.; Wu, L.; Chen, R., NRPS substratepromiscuity leads to more potent antitubercular sansanmycin analogues. J Nat Prod 2014, 77, (7), 1744-8.

12.  Li, Q.; Wang,L.; Xie, Y.; Wang, S.; Chen, R.;Hong, B., SsaA, a member of a novel class of transcriptional regulators,controls sansanmycin production in Streptomyces sp. strain SS through afeedback mechanism. J Bacteriol 2013, 195, (10), 2232-43.

13. Tang, X.;Gross, M.; Xie, Y.; Kulik, A.; Gust,B., Identification of mureidomycin analogues and functional analysis of anN-acetyltransferase in napsamycin biosynthesis. Chembiochem 2013, 14,(17), 2248-55.

14.  Wang, L.; Xie, Y. （co-first author）; Li, Q.; He, N.; Yao, E.; Xu, H.; Yu, Y.; Chen, R.; Hong,B., Draft genome sequence of Streptomyces sp. strain SS, which produces aseries of uridyl peptide antibiotic sansanmycins. Journal of bacteriology 2012,194, (24), 6988-9.

15. Li, Y. B.; Xie, Y. Y. (co-first author); Du, N.N.; Lu, Y.; Xu, H. Z.; Wang, B.; Yu, Y.; Liu, Y. X.; Song, D. Q.; Chen, R. X.,Synthesis and in vitro antitubercular evaluation of novel sansanmycinderivatives. Bioorganic & medicinalchemistry letters 2011, 21,(22), 6804

Academic Appointments

Youth editorial board member of Chinese Journal of Antibiotics, Expert in the field of random testing of national cosmetics, Communication evaluation committee member of China Academic Degrees & Graduate Education, Reviewers for Journal of Medicinal Chemistry, Journal of natural Products, Journal of Chromatography A, et al.