Microbial and Biochemical Pharmacy
LI Yinghong
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time：2021-12-08
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Name：Li Yinghong
Department：Organic Chemistry
Tel: (8610)63033012
Email: liyinghong@imb.pumc.edu.cn
Education & Research
Education：
2004/09 – 2009/06 Ph.D. in microbial and biochemical pharmacy, Peking Union Medical College
1999/09 – 2004/06 Bachelor, in Pharmacy, Shenyang Pharmaceutical University
Research:
2014/09 – Now Research Associate, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences
2010/09 –2012/09 Postdoc, Department of Pharmacy, South Dakota State University
2009/09 –2014/09 Research Assistant, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences
Research Field：
Medicinal chemistry and chemobiological studies on anti-bacterial and anti-tumor drugs
Research Interests：
Dr. Li has been engaged in medicinal chemistry and Chemical Biology. On one hand, she is engaged in searching for innovative drug candidates by the rational modification and optimization of Chinese natural quinolizidine alkaloids, for example, matrine and aloperine, and clarifying their anti-tumor and anti-metabolic biological activities, chemical biological mechanisms and chemical basis. On the other hand, she has devoted herself to the chemical biology of antibacterial agent. She is interested in explaining of antimicrobial resistance mechanism through chemibiological methods, so as to find new antimicrobial candidates.
Selected Publications：
1. Zeng Q#, Deng H#, Li Y#, Fan T, Liu Y, Tang S, Wei W, Liu X, Guo X, Jiang J, Wang Y*, Song D*. Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity. J Med Chem. 2021 Jan 14;64(1):768-781.
2. Fan T†, Ge M†, Guo Z, He H, Zhang N*, Li Y*, Song D. Discovery of 9O-Substituted Palmatine Derivatives as a New Class of anti-COL1A1 Agents via Repressing TGF-β1/Smads and JAK1/STAT3 Pathways. Molecules 2020, 25(4):773.
3. Wang K, Guo Z, Bao Y, Pang Y, Li Y*, He H*, Song D. Structure-Activity Relationship of Aloperine Derivatives as New Anti-Liver Fibrogenic Agents. Molecules 2020, 25(21): 4977.
4. Zhang D, Zhang X, Li Z, Tang S, Guo Z, Hu C, Zhang J, Song D, Li Y#. Comprehensive 2D-Quantitative Structure-Activity Relationship Study on Monobactam Analogues Against Gram-Negative Bacteria. J. Biomed. Nanotechnol. 2020,16, 941–953.
5. Liu T, Zeng Q, Zhao X,Wei W, Li Y*, Deng H*, Song D. Synthesis and Biological Evaluation of Fangchinoline Derivatives as Anti-Inflammatory Agents through Inactivation of Inflammasome. Molecules 2019, 24(6):1154.
6. Tang S†, Li Y†, Bao Y, Dai Z, Niu T, Wang K, He H*, Song D*. Novel cytisine derivatives exert anti-liver fibrosis effect via PI3K/Akt/Smad pathway. Bioorg Chem. 2019 Sep;90:103032.
7. Bao Y†, Pang Y†, Tang S, Niu T, Guo Z, He H*, Li Y*, Song D. 12N-Substituted Matrinol Derivatives Inhibited the Expression of Fibrogenic Genes via Repressing Integrin/FAK/PI3K/Akt Pathway in Hepatic Stellate Cells. Molecules 2019, 24, 3748.
8. Fan T†, Hu X†, Tang S, Liu X, Wang Y, Deng H, You X, Jiang J, Li Y*, Song D*. Discovery and Development of 8-Substituted Cycloberberine Derivatives as Novel Antibacterial Agents against MRSA. ACS Med Chem Lett. 2018, 9(5):484-489.
9. Niu T†, Niu W†, Bao Y, Liu T, Song D, Li Y*, He H*. Discovery of Matrinic Thiadiazole Derivatives as a Novel Family of Anti-Liver Fibrosis Agents via Repression of the TGFβ/Smad Pathway. Molecules 2018, 23(7): E1644.
10. Cheng XY†, Li YH†, Tang S, Zhang X, Wang YX, Wang SG, Jiang JD, Li YH*, Song DQ*. Synthesis and evaluation of halogenated 12N-sulfonyl matrinic butanes as potential anti-coxsackievirus agents. Eur J Med Chem. 2017, 126:133-142.
11. Li YH†, Wu ZY†, Tang S, Zhang X, Wang YX, Jiang JD, Peng ZG*, Song DQ*. Evolution of matrinic ethanol derivatives as anti-HCV agents from matrine skeleton. Bioorg Med Chem Lett. 2017, 27(9): 1962-1966.
12. Li YH†, Tang S†, Li YH, Cheng XY, Zhang X, Wang YX, Su F*, Song DQ*. Novel 12N-substituted matrinanes as potential anti-coxsackievirus agents. Bioorg Med Chem Lett. 2017, 27(4): 829-833.
13. Li Y, Peng Z, Gao L, Song D*. Synthesis and biological evaluation of sophocarpinic acid derivatives as anti-HCV agents, Acta Pharmaceutica Sinica B 2014, 4(4):307-312.
14. Li Y, Liu Y, Wang Y, Tang S, Song D*. Synthesis and biological evaluation of new 13-n-nonylprotoberberine derivatives as antitubercular agents. Acta Pharmaceutica Sinica B 2013, 3(1): 38-45.
15. Li YH†, Fu HG†, Su F, Gao LM, Tang S, Bi CW, Li YH, Wang YX*, Song DQ*. Synthesis and structure-activity relationship of 8-substituted protoberberine derivatives as a novel class of antitubercular agents. Chem Cent J. 2013, 7(1): 117.
16. Li Y, Yang Y, Guan X*. Benzofurazan sulfides for thiol imaging and quantification in live cells through fluorescence microscopy, Anal Chem. 2012.8.7, 84(15): 6877-6883.
17. Li YH†, Li Y†, Yang P, Kong WJ, You XF, Ren G, Deng HB, Wang YM, Wang YX, Jiang JD*, Song DQ*. Design, synthesis, and cholesterol-lowering efficacy for prodrugs of berberrubine. Bioorg Med Chem. 2010, 18(17): 6422-6428.
18. Li YH†, Yang P†, Kong WJ†, Wang YX, Hu CQ, Zuo ZY, Wang YM, Gao H, Gao LM, Feng YC, Du NN, Liu Y, Song DQ*, Jiang JD*. Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. J Med Chem. 2009, 52(2): 492-501.
Awards and Honors
1. 2019 Second Class Prize of Science and Technology of Chinese Pharmaceutical Association
2. 2016 Second Class Prize of Science and Technology of Chinese Pharmaceutical Association
3. Second prize of the 13th youth achievement exchange forum of Chinese Pharmaceutical Association, Sep 2016, Nanchang
4. Outstanding Poster in the 9th International Symposium for Chinese Medicinal Chemists, Aug 2014, Shenyang
5. "Zhen Yongsu Youth Science and Technology Award" of the 24th May 4th Youth thesis of Institute of medicinal biotechnology, May 2009, Beijing
