Name：LI Congran

Department：Pharmacology

Tel: (8610) 67058991

Email: congranli@imb.pumc.edu.cn

Education & Research Experience

2006/09 – Now Assistant professor (2006-2010), Associate professor (2010-2017), professor (2017-present), Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences

2016/04 – 2017/04 Visiting researcher, Uppsala University

2006/12 – 2009/06 Post-doctor, Georgia State University

2001/09 – 2006/07 Ph.D. in microbial and biochemical pharmacy, Peking Union Medical College

1997/09 – 2001/07 Bachelor in Pharmaceutical Chemistry, Shandong University

Research Field：

Pharmacodynamic study of antibacterial agents and mechanisms of bacterial resistance

Research Interests：

LI Congran has been working in areas of pharmacodynamic study of antibacterial agents and mechanisms of bacterial resistance for about 15 years. Her research interests are physiological study of bacteria and early diagnosis of bacterial infection; resistance mechanism study of bacteria to know how bacteria manage to fight against antibiotics; and new antibacterial compound / strategy exploration and development including pharmacodynamic study, action mechanism study, etc.

Selected Publications

1. Limin Dong, Jing Pang, Xiukun Wang, Youwen Zhang, Guoqing Li, Xinxin Hu, Xinyi Yang, Chung-Dar Lu, Congran Li*, Xuefu You*. Mechanism of pyocyanin abolishment caused by mvaT mvaU double knockout in Pseudomonas aeruginosa PAO1. Virulence,2020;11(1):57-67. (IF=5.542)

2. Qing Wang^#, Yuemeng Lv^#, Jing Pang, Xue Li, Xi Lu, Xiukun Wang, Xinxin Hu, Tongying Nie, Xinyi Yang, Yan Q. Xiong, Jiandong Jiang, Congran Li*, Xuefu You*. In vitro and in vivo activity of D-serine in combination with β-lactam antibiotics against methicillin-resistant Staphylococcus aureus. Acta Pharmaceutica Sinica B, 2019, 9(3): 496-504. (IF=5.808)

3. Genzhu Wang^#, Jing Pang^#, Xinxin Hu, Tongying Nie, Xi Lu, Xue Li, Xiukun Wang, Yun Lu, Xinyi Yang, Jiandong Jiang, Congran Li*, Yan Q Xiong* and Xuefu You*. Daphnetin: A Novel Anti-Helicobacter pylori Agent. Int J Mol Sci, 2019, 20(4), E850; https://doi.org/10.3390/ijms20040850. (IF=4.183)

4. Jian-Mei Zhang^#, Qing Wang^#, Tong-Yan Han, Jian-Hua Liu, Xin-Xin Hu, Feng Qiao, Xin-Yi Yang, Cong-Ran Li*, Xue-Fu You*. Structure Analysis of Transposons Carrying aac(6’)-aph(2’’) Gene in Enterococcus faecalis Isolated in Beijing China and Comparison of Their Transfer Efficiency. International Journal of Antimicrobial Agents, 2018, 52 (6) 799–804. (IF=4.615)

5. Yang Y, Li X, Zhang Y, Liu J, Hu X, Nie T, Yang X, Wang X, Li C*, You X*. Characterization of a hypervirulent multidrug-resistant ST23 Klebsiella pneumoniae carrying a blaCTX-M-24 IncFII plasmid and a pK2044-like plasmid. J Glob Antimicrob Resist, 2020; 22:674-679. (IF=2.706)

6. Cong-Ran Li^#, Qian-Qian Zhai^#, Xiu-Kun Wang, Xin-Xin Hu, Guo-Qing Li, Wei-Xin Zhang, Jing Pang, Xi Lu, Hong Yuan, Mikhail Fedorovich Gordeev, Le-Tian Chen, Xin-Yi Yang* and Xue-Fu You*. In vivo antibacterial activity of MRX-I, a new oxazolidinone. Antimicrob Agents Chemother, 2014, 58(4): 2418-2421. (IF= 4.476)

7. Xiangyu Yao^#, Congran Li^#, Jianmei Zhang and Chung-Dar Lu*. γ-Glutamyl Spermine Synthetase PauA2 as Potential Target of Antibiotic Development against Pseudomonas aeruginosa. Antimicrob Agents Chemother, 2012, 56(10): 5309-5314. (IF=4.659)

8. Cong-Ran Li^#, Yi Li^#, Guo-Qing Li, Xin-Yi Yang, Wei-Xin Zhang, Ren-Hui Lou, Jing-Fang Liu, Min Yuan, Philip Huang, Shan Cen, Li-Yan Yu, Li-Xun Zhao, Jian-Dong Jiang* and Xue-Fu You*. In vivo antibacterial activity of nemonoxacin, a novel non-fluorinated quinolone. J Antimicrob Chemother, 2010, 65(11): 2411-2415. (IF=4.7)

9. Congran Li and Chung-Dar Lu*. Arginine racemization by coupled catabolic and anabolic dehydrogenases. Proc Natl Acad Sci USA, 2009, 106(3): 906-911. (IF=9.4)

10. Congran Li, Hassan Wally, Shearman J Miller and Chung-Dar Lu*. The multifaceted proteins MvaT and MvaU, members of the H-NS family, control arginine metabolism, pyocyanin synthesis, and prophage activation in Pseudomonas aeruginosa PAO1. J Bacteriol, 2009, 191(20): 6211-6218. (IF=3.94)

Awards and Honors

1. Beijing Novel Star of Sciences &Technology in 2009

2. Innovation Team of Key Fields of Ministry of Science and Technology: Antimicrobial Agents Innovation Team in 2016

3. Novel Star of Peking Union Medical College in 2010

4. Institut Merieux - Chinese Academy of Medical Sciences Young Investigator Award on Antimicrobioal Resistance in 2016

5. Chinese Pharmaceutical Association - Sanofi-Aventis Young Investigator Award on Biopharmaceutical drugs in 2010

Academic Appointments

1. 2012/04 - 2016/03, Member of the Editorial Committee of Chinese Medicinal Biotechnology

2. 2014/11 – 2019/11, Vice director member of the Youth Committee of the second Anti-infective Pharmacology Committee of Beijing Pharmacological Society

3. 2020/10 – Now, Member of the third Anti-infective Pharmacology Committee of Beijing Pharmacological Society