Name：YOU Xuefu

Department：Pharmacology

Tel: (8610) 67010489

Email: xuefuyou@imb.pumc.edu.cn

Education & Research Experience

2004/09 –present Professor, Department of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences

1998/03–2004/08 Associate Professor, Department of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences

1993/06–1998/02 Assistant Professor, Department of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences

1990/09–1993/05 Research Assistant, Department of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences

1987/09–1990/07 MS in Microbial and Biochemical Pharmacy, Peking Union Medical College

1985/09–1987/07  Assistant, Department of Pharmacology, Jiangxi Medical Health School

1980/09–1985/07 Bachelor in Medicine, College of Medicine, Nanchang University

Research Field：

Pharmacological study of antimicrobial agents and mechanisms of bacterial resistance

Research Interests：

YOU Xuefu has been working in areas of pharmacological study of antibacterial agents and mechanisms of bacterial resistance for over 30 years. His research interests include: 1) discovery and strategy of new antimicrobial agents; 2) pharmacodynamics and molecular mechanisms of new antibacterial drugs; 3) pharmacokinetics and PK/PD of new antibacterial drugs; 3) mechanisms of bacterial resistance.

Selected Publications

Li Congran, You Xuefu*. Coagulation factors: a novel class of endogenous host antimicrobial proteins against drug-resistant gram-negative bacteria. Signal Transduct Target Ther. 2019 Nov 8;4:46. doi:10.1038/s41392-019-0083-4 (Research highlight)

1. Genzhu Wang^#, Liang Li^#, Xiukun Wang, Xue Li, Youwen Zhang, Jie Yu, Jiandong Jiang, Xuefu You*, Yan Q Xiong*. Hypericin enhances β-lactam antibiotics activity through inhibition of sarA in Methicillin-Resistant Staphylococcus aureus. Acta Pharmaceutica Sinica B. 2019;9(6):1174-82

2. Qing Wang^#, Yuemeng Lv^#, Jing Pang, Xue Li, Xi Lu, Xiukun Wang, Xinxin Hu, Tongying Nie, Xinyi Yang, Yan Q. Xiong, Jiandong Jiang, Congran Li*, Xuefu You*. In vitro and in vivo Activity of D-Ser in Combination with β-lactam Antibiotics against Methicillin-Resistant Staphylococcus aureus. Acta Pharmaceutica Sinica B. 2019;9(3):496-504

3. Zhai Q, Pang J, Li G, Li C, Yang X, Yu L, Wang Y, Li J, You X*. Validated LC--MS/MS method for determination of YH-8, a novel PKnB inhibitor, in rat plasma and its application to pharmacokinetic study. Acta Pharmaceutica Sinica B.2015 Sep; 5(5):467-72

4. Nie L^#, Lv Y^#, Yuan M, Hu X, Nie T, Yang X, Li G, Pang J, Zhang J, Li C, Wang X*, You X*. Genetic basis of high level aminoglycoside resistance in Acinetobacter baumannii from Beijing, China. Acta Pharmaceutica Sinica B. 2014 Aug;4(4):295-300

5. Cui AL^#, Hu XX^#, Gao Y, Jin J, Yi H, Wang XK, Nie TY, Chen Y, He QY, Guo HF, Jiang JD, You XF*, Li ZR*.The Synthesis and Bioactivity Investigation of the Individual Components of Cyclic Lipopeptide Antibiotics. Journal of Medicinal Chemistry. 2018, 61: 1845-1857

6. Dong LM, Pang J, Wang XK, Zhang YW, Li GQ, Hu XX, Yang XY, Lu CD, Li CR*,You XF*. Mechanism of pyocyanin abolishment caused by mvaT mvaU double knockout in Pseudomonas aeruginosa PAO1. Virulence. 2020,11(1): 57-67

7. Guo-Qing Li^#, Xiao-Gang Bai^#, Cong-Ran Li, Xin-Yi Yang, Xin-Xin Hu, Min Yuan, Wei-Xin Zhang, Ren-Hui Lou, Hui-Yuan Guo, Jian-Dong Jiang‡ and Xue-Fu You*‡. In vivo antibacterial activity of Chinfloxacin, a new fluoroquinolone antibiotic. J Antimicrobial Chemotherapy. 2012, 67(4): 955-961

8. Cong-Ran Li^#, Yi Li^#, Guo-Qing Li, Xin-Yi Yang, Wei-Xin Zhang, Ren-Hui Lou, Jing-Fang Liu, Min Yuan, Philip Huang, Shan Cen, Li-Yan Yu, Li-Xun Zhao, Jian-Dong Jiang* and Xue-Fu You*. In vivo antibacterial activity of nemonoxacin, a novel non-fluorinated quinolone. J Antimicrobial Chemotherapy. 2010; 65(11): 2411-2415

9. Youwen Zhang, XiukunWang, Xue Li, Limin Dong, Xinxin Hu, Xi Lu, JingPang, Guoqing Li, Xinyi Yang, Congran Li and Xuefu You*. Synergistic effect of colistin combined with PFK-158 against colistin-resistant Enterobacteriaceae. Antimicrob Agents Chemother. 2019 Jun 24;63(7). pii:e00271-19. doi: 10.1128/AAC.00271-19

Awards and Honors

1. Ten Thousand Talent Program Leading Scientist in 2017.

2. Establishment and application of the key technology of preclinical pharmacodynamic evaluation platform of antimicrobial agents in China, The second prize of National Prize for Progress in Science and Technology in 2011.

3. Outstanding Mid-Aged Expert of the Ministry of Public Health in 2012.

4. Innovation Team of Key Fields of Ministry of Science and Technology: Antimicrobial Agents Innovation Team in 2015.

5. Beijing Training Project For The Leader Talents In Science and Technology in 2015.

6. The 14^th Wu Jieping-Paul Janssen Medical and Pharmaceutical Award in 2013.

Academic Appointments

1. Vice director member of the Member of Antibiotics Committee of Chinese Pharmaceutical Association.

2. Vice director member of the Chemotherapy Pharmacology Committee of Chinese Pharmacological Society.

3. Vice director member of the Anti-infective Pharmacology Committee of Beijing Pharmacological Society.

4. Vice director member of the Beijing Environmental Mutagen Society.

5. Director of Beijing Key Laboratory of Antimicrobial Agents.

6. Vice director of the Department of Microbial and Biochemical Pharmacy of PUMC.