Name：ZHANG Jingpu

Department：Pharmacology

Tel: (8610)63186645

Email: zhangjingpu@imb.pumc.edu.cn

Education & Research Experience

2007/03 – Now Professor, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences

1995/01 – 2007/03 Associate Professor, PI, Institute of Genetics and developmental Biology , Chinese Academy of Sciences

2001/09-2006/12 Ph.D, Graduate School of Chinese Academy of Sciences, Institute of Genetics and developmental Biology, Chinese Academy of Sciences

2000/11-12: Visit scholar in National University of Australia. Canberra, Australia 1999/03-06: Visit scholar in National University of Australia. Canberra, Australia

1994/01-1995/01 visiting fellow in Dept of Genetics, Umea University, Sweden

1987/08-1994/01 Assistant professor, Institute of Biophysics, Chinese Academy of Sciences

1984/09-1987/07 Master student, Graduate School of Chinese Academy of Agriculture Science

1982/08-1984/09 Assistant Researcher in the laboratory of Enzyme, Institute of  Microbiology, Hebei Academy of Science, Baoding, China

1978/09-1982/07 Bachelor student, Dept. of Biology, Lanzhou University. Lanzhou, China

Research Field：

Molecular toxicology of drugs and molecular mechanism of pharmacology in virus infectious diseases, glycolipid metabolic diseases and neurodegenerative diseases

Research Interests：

Prof. Zhang has been engaged in molecular toxicology of drugs and molecular mechanism of pharmacology in virus infectious diseases, glycolipid metabolic diseases and neurodegenerative diseases using the model animal zebrafish and cell models. She focuses on correlations of drug activity -disease-autophagy and has found a variety of important mechanisms of pathology and pharmacology; and new drug targets are developed based on the findings. Meanwhile, her group has been finding and researching new genes and their biological functions, and revealing new communication between immune system and autophagic mechanism. In drug toxicology, she mainly focuses on finding toxicity of drugs comprehensively and systematically in vivo using zebrafish.

Selected Publications

1. Miao-Qing Zhang, Qiong Zhao & Jing-Pu Zhang*. A new transcription factor ATG10S activates IFNL2 transcription by binding at an IRF1 site in HepG2 cells, Autophagy, 2020, 16(12):2167-2179.

2. Yuan-yuan Ma, Jian-rui Li, Zong-gen Peng, and Jing-pu Zhang*. IL28A protein homotetramer structure is required for autolysosomal degradation of HCV-NS5A in vitro. Cell Death Dis. 2020, 11(3): 200.

3. Yang-Min Zheng, Bo Chen, Jiandong Jiang, Jingpu Zhang*. Syntaxin 1B mediates berberine’s roles on epilepsy-like behavior in a pentylenetetrazole-induced seizure zebrafish model.  Front. Mol. Neurosci., 2018, 11:378.

4. Miao-Qing Zhang, Jian-Rui Li, Zong-Gen Peng and Jing-Pu Zhang* Zhang M-Q, Li J-R, Peng Z-G and Zhang J-P*. Differential Effects of Autophagy-Related 10 Protein on HCV Replication and Autophagy Flux Are Mediated by Its Cysteine44 and Cysteine135. Front. Immunol. 2018, 9:2176.

5. Zhan-ying Hu, Bo Chen, Jing-pu Zhang*, Yuan-yuan Ma. Up-regulation of autophagy-related gene 5 (ATG5) protects dopaminergic neurons in a zebrafish model of Parkinson's disease. J Biol Chem. 2017, 292(44): 18062–18074.

6. Qiong Zhao, Zhan-Ying Hu, Jing-Pu Zhang*, Jian-Dong Jiang, Yuan-yuan Ma, Jian-rui Li, Zong-gen Peng & Jin-hua Chen. Dual Roles of Two Isoforms of Autophagy-related Gene ATG10 in HCV-Subgenomic replicon Mediated Autophagy Flux and Innate Immunity. Scientific Reports. 2017, 7: 11250 | DOI:10.1038/s41598-017-11105-3.

7. Xiang-Hui Meng, Bo Chen and Jing-Pu Zhang*. Intracellular Insulin and Impaired Autophagy in a Zebrafish model and a Cell Model of Type 2 diabetes. International Journal of Biological Sciences.  2017, 13(8):985-995.

8. Z-y Hu, Q-y Zhang, W Qin, J-w Tong, Q Zhao, Y Han, J Meng and J-p Zhang*. Gene miles-apart is required for formation of otic vesicle and hair cells in zebrafish. Cell Death and Disease 2013, 4:e900.

9. Zhanying Hu, Jingpu Zhang* and Qingyou Zhang. Expression pattern and functions of autophagyrelated gene atg5 in zebrafish organogenesis. Autophagy 2011, 7:12, 1–14.