Name：HONG Bin

Department：Department of Biotechnology

Tel: (8610)63028003

Email: hongbin@imb.pumc.edu.cn; binhong69@hotmail.com

Education & Research Experience

1996/08 – Now Research assistant Professor, associate Professor, Professor, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences

1999/04 –2000/06 Postdoc with Prof. Jozef Anné, Rega Institute, Katholeike Universiteit Leuven, Leuven, Belgium

2005/07–2006/06 Visiting scholar, Department of Biology, Leeds University, Leeds, UK

1991/09 – 1996/07 Ph.D. in Microbial Pharmacy, Peking Union Medical College, Beijing, China

1987/09 – 1991/07 B.S. in Biochemistry, Nanjing University, Nanjing, China

Research Field：

Synthetic biology, Drug discovery and development

Research Interests：

Dr. Hong has been engaged in the biosynthesis and regulation mechanism of microbial natural products, and synthetic biology for drug innovation. She is also engaged in the drug discovery and development of novel anti-atherosclerosis, anti-virus drugs and antibiotics, and the mechanism of drug action.

Selected Publications

1. Yuanyuan Shi, Zhibo Jiang, Xiaowen Hu, Xiaomin Hu, Renjie Gu, Bingya Jiang, Lijie Zuo, Xingxing Li, Hongmin Sun, Cong Zhang, Lifei Wang, Linzhuan Wu*, Bin Hong*. The cytochrome P450 catalyzing C-S bond formation in S-heterocyclization of chuangxinmycin biosynthesis. Angew Chem Int Ed, 2021, doi: 10.1002/anie.202015814.

2. Xingxing Li^#, Chunyan Su^#, Zhibo Jiang, Yuxin Yang, Yue Zhang, Mengxia Yang, Xiumin Zhang, Yu Du, Jin Zhang, Li Wang*, Jiandong Jiang*, Bin Hong*. Berberine Attenuates Choline-Induced Atherosclerosis by Inhibiting Trimethylamine and Trimethylamine-N-Oxide production via Manipulating the Gut Microbiome. npj Biofilms Microbiomes, 2021, 7:36.

3. Xuelei Wang, Xiaofang Chen, Xiumin Zhang, Chunyan Su, Mengxia Yang, Wei He, Yu Du, Shuyi Si, Li Wang*, Bin Hong*. A small-molecule inhibitor of PCSK9 transcription ameliorates atherosclerosis through the modulation of FoxO1/3 and HNF1α. EBioMedicine, 2020, (52):102650.

4. Yu Du, Xingxing Li, Chunyan Su, Mei Xi, Xiumin Zhang, Zhibo Jiang, Li Wang, Bin Hong*. Butyrate protects against high-fat diet-induced atherosclerosis via up-regulating ABCA1 expression in apolipoprotein E-deficiency mice. Br J Pharmacol, 2020, 177:1754-1772.

5. Xingxing Li, Tengfei Yu, Qing He, Kenneth J. McDowall, Bingya Jiang, Zhibo Jiang, Linzhuan Wu, Guangwei Li, Qinglian Li, Songmei Wang, Yuanyuan Shi, Lifei Wang*, Bin Hong*. Binding of a biosynthetic intermediate to AtrA modulates the production of lidamycin by Streptomyces globisporus. Mol Microbiol, 2015, 96(6):1257-1271. (F1000Prime Recommendation)

Awards and Honors

2003 Beijing Science and Technology Rising Star

2003 Excellent Young Teachers Program of MOE, China

2006 New Century Excellent Talents in University, MOE, China

2011 Distinguished Professor of “Scholar of Peking Union Medical College”

Academic Appointments

Editorial board member of 《Expert Opinion on Drug Discovery》,《Acta Microbiologica Sinica》,《International Journal of Pharmaceutical Research》,《Chinese Journal of Antibiotics》,《Chinese Medicinal Biotechnology》, Member of Professional Committee of Enzyme and Fermentation Biotechnology, China Medicinal Biotechnology Association