Name：Wang Apeng

Department：Department of Organic Chemistry

Tel: (8610)63165265

Email: wangapeng@imb.pumc.edu.cn

Education & Research Experience

2019/7 –Now Associate research fellow, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences

2016/9 – 2019/7 Assistant research fellow, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences

2013/9 - 2016/7，Ph.D. in Institute of Materia Medica，Chinese Academy of Medical Sciences

2007/9 - 2013/7，B.S. and M.S. in Beijing University of Chemical Technology

Research Field

Our research interests mainly focuse on pharmaceutical chemistry research of antibacterial, antiviral and anti-tumor drugs.

Research Interests

I have been engaged in pharmaceutical chemistry research of anti-MDR-TB drugs, Quorum sensing inhibitors and antiviral drugs via Computer-Aided Drug Design, structure optimization, activity assay and druggability evaluation. I am also interested in the anti-tumor drugs development via the ProTide and prodrug technologies.

Selected Publications

1. Apeng Wang, Yang Yang, Yangsheng Jun, Bin Wang, Kai Lv, Mingliang Liu, Huiyuan Guo,Yu Lu，Synthesis, evaluation and CoMFA/CoMSIA study of nitrofuranyl methylN-heterocycles as novel antitubercular agents，Bioorganic & Medicinal Chemistry. 2018，26，2073-2084.

2. Apeng Wang, Kai Lv, Linhu Li, Hongtao Liu, Zeyu Tao, Bin Wang, Mingliang Liu, Chao Ma, Xican Ma, Bing Han, Aoyu Wang, Yu Lu，Design, synthesis and biological activity of N-(2-phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamides as new antitubercular agents，European Journal of Medicinal Chemistry. 2019, 178, 715-725.

3. Apeng Wang, Shuo Wu, Zeyu Tao, Xiaoning Li, Kai Lv, Chao Ma, Yuhuan Li, Linhu Li，Mingliang Liu，Design, Synthesis, and Anti-HBV Activity of New Bis(L‑amino acid) Ester Tenofovir Prodrugs，ACS Med. Chem. Lett. 2019, 10, 991−995.

4. Apeng Wang, Kai Lv, Zeyu Tao, Jian Gu, Lei Fu, Mingliang Liu, Baojie Wan, Scott G. Franzblau, Chao Ma , Xican Ma, Bing Han, Aoyu Wang, Shijie Xu,Yu Lu，Identification of benzothiazinones containing an oxime functional moiety as new anti-tuberculosis agents，European Journal of Medicinal Chemistry. 2019, 181, 111595.

5. Apeng Wang, Chao Ma, Yun Chai, Xiujun Liu, Kai Lv, Lei Fu, Bin Wang, Xuedong Jia, Mingliang Liu, Yu Lu，Identification of benzothiazinones containing 2-benzyl-2,7-diazaspiro[3.5]nonane moieties as new antitubercular agents，European Journal of Medicinal Chemistry. 2020, 200, 112409.

6. Apeng Wang, Yu Lu, Kai Lv, Chao Ma, Shijie Xu, Bin Wang, Aoyu Wang, Guimin Xia, Mingliang Liu，Design, synthesis and antimycobacterial activity of new benzothiazinones inspired by rifampicin/rifapentine，Bioorganic Chemistry. 2020, 102, 104135.

7. Apeng Wang, Shijie Xu, Yun Chai, Guimin Xia, Bin Wang, Kai Lv,Chao Ma, Dan Wang, Aoyu Wang, Xiaoyu Qin, Mingliang Liu, Yu Lu，Design, synthesis and biological activity of N-(amino)piperazine-containing benzothiazinones against Mycobacterium tuberculosis, European Journal of Medicinal Chemistry. 2021, 218, 113398.