Name：LI Zhuorong

Department：Medicinal Chemistry

Tel: (8610)83152017

Email: lizhuorong@imb.pumc.edu.cn

Education & Research Experience

1983.08-now: successively served as Assistant Professor, Associate Professor, Professor, Director of the Organic Chemistry Laboratory, and Deputy Director of the Institute of Medicinal Biotechnology，Chinese Academy of Medical Sciences and Peking Union Medical College

1997/10-1999/08  Visiting scholar in Department of Medicinal Chemistry and Pharmaceutics, College of Pharmacy, Oklahoma University Health Sciences Center

1992/12-1994/12  Visiting researcher in The Kitasato Institute, The Kitasato University, Tokyo, Japan

1985/09-1988/07  Peking Union Medical College, Master

1979/09-1983/07  Beijing Medical University, Bachelor

Research Field：

Drug molecular design, synthesis and structure-activity relationship research and new drug development

Research Interests：

Professor Li's research field is medicinal chemistry, and the main research directions include molecular design and structure-activity relationship of antibacterial, antiviral, antitumor and antiosteoporosis drugs, and new drug development. Presided over more than 10 national science and technology projects. Published more than 160 papers in academic journals, including Autophagy, Hepatology, J. Med. Chem, Eur J Med. Chem., ACS Infectious Diseases, etc. Obtained more than 20 invention patents.

Selected Publications

1. Dai-Jie Chen,^1,* A-Long Cui,^2,* Jia-Rong Chen,³ Ping Yang,¹ Jie Jin,² Lei Shao,⁴ and Zhuo-Rong Li². The Low-Alkalinity Polymyxin Derivative, AL-6, Shows High Activity Against Multidrug-Resistant Acinetobacter baumannii Clinical Isolates In Vitro and A. baumannii ATCC 19606 In Vivo: Preliminary Analysis of the Antibacterial Mechanism. Microbial Drug Resistance, 2021. DOI: 10.1089/mdr.2019.0474.

2. Xinyue Hu^a,b‡, Hailun Jang^a‡, Weiqi Bai^a, Xiujun Liu^a, Qingfang Miao^a, Linlin Wang^a, Jie Jin^a, Along Cui^a, Rui Liu^a*, and Zhuorong Li^a*. Synthesis, characterization, and targeted chemotherapy of SCT200-linker-monomethyl auristatin E conjugates. Eur J Med Chem. 2021, 216:113297.

3. Si-tu Xue¹, Ke Li¹, Yang Gao, Lu-yao Zhao, Yan Gao, Hong Yi, Jian-dong Jiang^*, and Zhuo-rong Li^*. The role of the key autophagy kinase ULK1 in hepatocellular carcinoma and its validation as a treatment target. Autophagy, 2020, 16:10, 1823-1837.

4. Xinbei Jiang, Jiali Tan, YixuanWang, Jinhua Chen, Jianrui Li, Zhi Jiang, Yanni Quan, Jie Jin, Yuhuan Li, Shan Cen, Yanping Li^*, Zonggen Peng^*, Zhuorong Li^*. 2-((4-Arylpiperazin-1-yl)methyl)benzonitrile Derivatives as OrallyAvailable Inhibitors of Hepatitis C Virus with a Novel Mechanism of Action. Journal of Medicinal Chemistry. 2020; 63(11):5972-5989.

5. Si-tu Xue ¹, Lei Zhang ¹, Zhuo-song Xie, Jie Jin, Hui-Fang Guo, Hong Yi, Zong-ying Liu^**, Zhuo-rong Li^*. Substituted benzothiophene and benzofuran derivatives as a novel class of bone morphogenetic Protein-2 upregulators: Synthesis, antiosteoporosis efficacies in ovariectomized rats and a zebrafish model, and ADME properties. European Journal of Medicinal Chemistry, 2020, 200:112465.  

6. A-Long Cui^‡, Xin-Xin Hu^‡, Yang Chen^‡, Jie Jin, Hong Yi, Xiu-Kun Wang, Qi-Yang He, Xue-Fu You^*, Zhuo-Rong Li^*. Design, Synthesis, and Bioactivity of Cyclic Lipopeptide Antibiotics with Varied Polarity, Hydrophobicity, and Positive Charge Distribution. ACS Infectious Diseases, 2020, 6(7):1796-1806.

7. Jing Geng, Yuhong Wang, Lei Zhang, Co Li, Weijin Sheng^*, Zhuorong Li^*, Min Jiang1. The Cajanine Derivative LJ101019C Regulates the Proliferation and Enhances the Activity of NK Cells via Kv1.3 Channel-Driven Activation of the AKT/mTOR Pathway. Phytomedicine, 2020, 66:153113.

8. Hailun Jiang^†, Li Zeng^1†, Xueqi Dong, Shuilong Guo, Jianguo Xing, Zhuorong Li^*, Rui Liu^*. Tilianin Extracted From Dracocephalum moldavica L. Induces Intrinsic Apoptosis and Drives Inflammatory Microenvironment Response on Pharyngeal Squamous Carcinoma Cells via Regulating TLR4 Signaling Pathways. Front Pharmacol, 2020; 11: 205.

9. Wang Linlin^#, Fang Jiansong^#, Jiang Hailun, Wang Qian, Xue Situ, Li Zhuorong^*, Liu Rui^*. 7-pyrrolidinethoxy-4'-methoxyisoflavone prevents amyloid β–induced injury by regulating histamine H3 receptor-mediated cAMP/CREB and AKT/GSK3β pathways. Front Neurosci, 2019, 13:334.

10. Wang Linlin^#, Liu Jianghong^#, Wang Qian, Jiang Hailun, Zeng Li, Li Zhuorong^*, Liu Rui^*. MicroRNA-200a-3p mediates neuroprotection in Alzheimer-related deficits and attenuates amyloid-beta overproduction and tau hyperphosphorylation via coregulating BACE1 and PRKACB. Front Pharmacol, 2019, 10:806.

11. Xin-yue Hu^‡, Rong Wang^‡, Jie Jin, Xiu-jun Liu, A-long Cui, Lian-qi Sun, Yan-ping Li, Yi Li, Yu-cheng Wang, Yong-su Zhen, Qing-fang Miao^*, Zhuo-rong Li^*. An EGFR-Targeting Antibody-Drug Conjugate LR004-VC-MMAE: Potential in Esophageal Squamous Cell Carcinoma and Other Malignancies. Molecular oncology, 2019; 13(2):246-263.

12. A-Long Cui^‡, Xin-Xin Hu^‡, Yan Gao, Jie Jin, Hong Yi, Xiu-Kun Wang, Tong-Ying Nie, Yang Chen, Qi-Yang He, Hui-Fang Guo, Jian-Dong Jiang, Xue-Fu You^*, Zhuo-Rong Li^*. The Synthesis and Bioactivity Investigation of the Individual Components of Cyclic Lipopeptide Antibiotics. Journal of Medicinal Chemistry, 2018, 61, 1845-1857.

13. Xing-Yue Ji, Jin-Hua Chen, Guang-Hui Zheng, Meng-Hao Huang, Lei Zhang, Hong Yi, Jie Jin, Jian-Dong Jiang, Zong-Gen Peng^*, Zhuo-Rong Li^*. Design and Synthesis of Cajanine Analogues against Hepatitis C Virus through Down-Regulating Host Chondroitin Sulfate N-Acetylgalactosaminyltransferase 1. J Med Chem, 2016, 59(22):10268-10284.

14. Zong-Gen Peng, Zhi-Yun Zhao, Yan-Ping Li, Yu-Ping Wang, Lan-Hu Hao, Bo Fan, Yu-Huan Li, Yue-Ming Wang, Yong-Qiang Shan, Yan-Xing Han, Yan-Ping Zhu, Jian-Rui Li, Xue-Fu You, Zhuo-Rong Li^*, Jian-Dong Jiang^*. Host Apolipoprotein B Messenger RNA-Editing Enzyme Catalytic Polypeptide-Like 3G Is an Innate Defensive Factor and Drug Target Against Hepatitis C Virus. Hepatology, 2011, 53 (4): 1080-1089.

15. Hui-fang Guo^†, Hua-yi Shao^†, Zhao-yong Yang^†, Si-tu Xue, Xue Li, Zong-ying Liu, Xiao-bo He, Jian-dong Jiang, Yue-qin Zhang, Shu-yi Si^* and Zhuo-rong Li^*. Substituted Benzothiophene or Benzofuran Derivatives as a Novel Class of Bone Morphogenetic Protein-2 Up-Regulators: Synthesis, Structure-Activity Relationships, and Preventive Bone Loss Efficacies in SAMP6 and Ovariectomized Rats. Journal of Medicinal Chemistry, 2010; 53, 1819-1829.

Awards and Honors

2019: Biomedical Innovation Award of Chinese Pharmaceutical Association

2017: Expert on Outstanding Contribution of the National Ministry of Health

2009: Specialist Allowance of the Chinese State Department.

Academic Appointments

Served as a member of many professional associations in the field of pharmacy or journal editors: member of the Biochemical and Biotechnology Professional Committee of the Chinese Pharmaceutical Association, member of the Medicinal Chemistry Professional Committee of the Chinese Pharmaceutical Association, member of the Expert Committee of the Polypeptide Medicine Branch of the Chinese Biochemical Pharmaceutical Association, and Vice Chairman of Medicinal Chemistry Professional Committee of the Beijing Pharmaceutical Association, editorial board of Acta Pharmacentica Sinica B,  Acta Pharmacentica Sinica, Chinese Journal of Antibiotics, Chinese Journal of Medical Biotechnology, etc.