Name：LI Guiling

Department：Pharmaceutics Laboratory

Tel: (8610)67022156

Email: liguiling@imb.pumc.edu.cn

Education & Research

Education

1995/09-1998/07  M.S. in Pharmaceutics, Shenyang Pharmaceutical University

1991/09-1995/07  B.S. in Pharmaceutics, Shenyang Pharmaceutical University

Research

2015.09-Now Research professor, Institute of Medicinal and Biotechnology, Chinese Academy of Medical Sciences

2008.09-2015.08 Research associate professor, Institute of Medicinal and Biotechnology, Chinese Academy of Medical Sciences

2002.09-2008.08 Research assistant professor, Institute of Medicinal and Biotechnology, Chinese Academy of Medical Sciences

1998.09-2002.08 Research assistant, Institute of Medicinal and Biotechnology, Chinese Academy of Medical Sciences

Research Field：

Preparation of new drugs and innovative drug delivery systems

Research Interests

Dr. Li has been engaged in the preparation of new drugs and innovative drug delivery systems (DDS), specifically for anti-fibrosis drug delivery system, multifunctional nanoparticles targeting drug-resistant bacteria and their microenvironment, novel sustained and controlled release and targeted DDS as well as in-situ-gel DDS recently.

Selected Publications

[1] Xia Niu^#, Xiaomei Wang^#, Bingyu Niu, Guoqing Li, Xinyi Yang, Yucheng Wang* and Guiling Li*. Novel IMB16-4 Compound Loaded into Silica Nanoparticles Exhibits Enhanced Oral Bioavailability and Increased Anti-Liver Fibrosis In Vitro. Molecules. (IF=3.267), Molecules, 2021, 26: 1545.

[2] Xucheng Hou, Wenxi Zhang, Yansha Meng, Wenkai Zhou, Guanghua Peng, Jiongxi Lei, Shuangchen Cong, Maoyuan Song, Guiling Li*, and Xinru Li*. A new anti-immune evasion strategy against methicillin-resistant Staphylococcus aureus (MRSA) infections: simulating complement immunotherapy based on complement-mimic antibiotic delivery system. Advanced Therapeutics. 2020, DOI: 10.1002/202000167.

[3] Maoyuan Song^#, Jiaxing Wang^#, Jiongxi Lei, Guanghua Peng, Wenxi Zhang, Yuanyuan Zhang, Mengya Yin, Jiajia Li, Yajie Liu, Xiaomeng Wei, Xinru Li^* and Guiling Li^*. Preparation and Evaluation of Liposomes Co-Loaded with Doxorubicin, Phospholipase D Inhibitor 5-Fluoro-2-Indolyl Deschlorohalopemide (FIPI) and D-Alpha Tocopheryl Acid Succinate (α-TOS) for Anti-Metastasis. Nanoscale Research Letters (IF=3.159), 2019, 14 (1): 138.

[4] Hongqiang Zhai^#, Yuli Wang^#, Menghua Wang, Shuai Liu, Feifei Yu, Chunsheng Gao, Guiling Li^*, Qiang Wu*. Construction of a Glutathione-Responsive and Silica-Based Nanocomposite for Controlled Release of Chelator Dimercaptosuccinic Acid.International Journal of Molecular Sciences (IF=4.183), 2018, 19, 3790.

[5] Guanghua Peng, Xucheng Hou, Wenxi Zhang, Maoyuan Song, Mengya Yin, Jiaxing Wang, Jiajia Li, Yajie Liu, Yuanyuan Zhang, Wenkai Zhou, Xinru Li*, Guiling Li*. Alkyl rhamnosides, a series of amphiphilic materials exerting broad-spectrum anti-biofilm activity against pathogenic bacteria via multiple mechanisms. Artificial Cells, Nanomedicine and Biotechnology (IF=4.462).  2018, 46(sup3): S217-S232.

[6] Yansha Meng^#, Xucheng Hou^#, Jiongxi Lei, Mengmeng Chen, Shuangchen Cong, Yuanyuan Zhang, Weiming Ding, Guiling Li*, and Xinru Li*. Multi-functional Liposomes Enhancing Target and Antibacterial Immunity for Antimicrobial and Anti-Biofilm against Methicillin-Resistant Staphylococcus aureus. Pharmaceutical Research (IF=3.002)，2016, 33:763–775.

[7] Xinru Li*, Xucheng Hou, Weiming Ding, Shuangchen Cong, Yuanyuan Zhang, Mengmeng Chen, Yansha Meng, Jiongxi Lei, Yan Liu and Guiling Li*. Sirolimus-loaded polymeric micelles with honokiol for oral delivery. Journal of Pharmacy and Pharmacology (IF=2.363), 2015, 67(12):1663-1672.

[8] Weiming Ding^#, Xucheng Hou^#, Shuangchen Cong, Yuanyuan Zhang, Mengmeng Chen, Jiongxi Lei, Yansha Meng, Xinru Li^*, and Guiling Li^*. Co-delivery of honokiol, a constituent of Magnolia species, in a self-microemulsifying drug delivery system for improved oral transport of lipophilic sirolimus. Drug Delivery (IF=6.402), 2016, 23(7): 2513-2523.

[9] Weiming Ding, Yanfang Li, Xucheng Hou, Guiling Li^*. Bleomycin A6-loaded anionic liposomes with in situ gel as a new antitumoral drug delivery system. Drug Delivery (IF=6.402), 2016, 23(1): 88-94.