Name：Li Yan

Department：National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College

Tel: (8610)63180623

Email: liyan@imb.pumc.edu.cn

Education & Research

2007/9 – Now Assistant research professor and associate research professor in the Institute of Medicinal Biotechnology, Peking Union Medical College & Chinese Academy of Medical Sciences. I got the qualification of research professor at 2020。

2004/9-2007/7 ph.D in Institute of Medicinal Biotechnology & Chinese Academy of Medical Sciences.

2004/9-2007/7 Master in Foundation Research Institute &Shandong Academy Medical Sciences.

2004/9-2007/7 Bachelor in Department of biology & Shandong Normal University.

Research Field：

Discovery of anti-fungal and anti-bacterial antibiotics and the pharmacological study of antibiotics

Research Interests：

I have been engaged in discovery and research of anti-Gram negative bacteria antibiotics targeting outer membrane synthesis and pharmacology of anti-fungal antibiotics

Selected Publications

Representative articles in the field of antibiotics published （the first and corresponding authors）in recent years：

(1)Lin,Yuan^#; Li,Yan^#; Zhu,Yuanjun; Zhang,Jing; Li,Yongzhen; Liu,Xiao; Jiang,Wei;Yu,Shishan; You,Xuefu; Xiao,Chunling; Hong,Bin; Wang,Yanchang*; Jiang,Jiandong*; Si,Shuyi*. Identification of novel anti-tuberculosis agents that target ribosome subunit interaction using yeast two-hybrid system. PNAS, 2012,43(109): 17412 -17417.
(2)Wang,Weiwei; Liu,Chao; Zhu,Ningyu; Lin,Yuan; Jiang,Jiandong; Wang, Yanchang; Li,Yan*; Si,Shuyi*. Identification of anti-Gram-negative bacteria agents targeting the interaction between ribosomal proteins L12 and L10.ACTA PHARMACEUTICA SINICA B, 2018, 5(8):772-783.

(3)Xuelian Zhang^#; Yan Li^#; Weiwei Wang; Jing Zhang; Yuan Lin; Bin Hong; Xuefu You; Danqing Song; Yanchang Wang; Jiandong Jiang*; Shuyi Si*. Identification of an anti-Gram-negative bacteria agent disruption the interaction between lipopolysaccharide transporters LptA and LptC. Int J Antimicrob Agents, 2019, 53(4):442-448.

(4)Li,Yan^#; Zhu,Xiaohong^#; Zhang,Jing; Lin,Yuan; You,Xuefu; Chen,Minghua; Wang,Yanchang; Zhu,Ningyu*; Si,Shuyi*. Idengtification of a Compound That Inhibitis the Growth of Gram-Negative Bacteria by Blocking BamA-BamD Interaction. Frontiers in Microbiology,2020,11.

(5)Li,Yan^#; Sunhong Min^#; Zhu,xiaohong; Bian,Cong; Wang,Yangchang*; Si,Shuyi*. Identification of New Antifungal Agents Targeting Chitin Synthesis by a Chemical-Genetic Method. Molecules, 2019,24(17).

(6)代晓伟，朱小红，司书毅，李妍*，袁丽杰*。基于BLI技术的脂多糖转运蛋白LptA/LptC相互作用检测方法的建立。生物工程学报，2021，2月。

(7)Yunyu Chen, Xiayi Niu, Yan Li*, Xiaoping Liu*. Development of an ELISA-based high throughput screening method for novel anticancer agents targeting β-catenin/Lef1 interaction.  Chin J Biotech, 2019, 34（4）: 707-717. 

Awards and Honors

2013 Satoshi ōmura award of Institute of Medicinal Biotechnology.

2017 Second prize of the Second Micro Class Teaching Competition of Institute of Medicinal Biotechnology.