Name：Li，Xiaoyu

Department：immunology

Tel: (8610)63188604

Email: lixiaoyu@imb.pumc.edu.cn

Education & Research Experience

Working Experience

2020 – present: Professor, Institute of Medicinal Biotechnology, CAMS

2011 – 2020: Associate professor, Institute of Medicinal Biotechnology, CAMS

2002 –2005: Researcher, Shanghai Kehua Biotechnology Company Limited

1995 – 1999: Assistant Engineer, Lanzhou Institute of Biological Products

Education Experience

2010 – 2011 Post doctor, Lady Davis Institute, Jewish General Hospital, Montreal, Canada

2006 –2010 Ph.D., Mcgill Univercity, Canada

1999 –2002 Master, National Institute for Viral Disase Control and Prevention, CCDC

1991 –1995 Bachelor, Shool of Pharmacy lanzhou university

Research Field：

Anti-viral drug research, Endogenous retrovirus (retrotransposon) research

Research Interests：

The research field of our group involves basic research of virology and development of antiviral drugs, especially focusing on anti-viral host restriction factors. On the other hand, we also engage in studying the retrotransposon LINE-1, which is the only currently known active autonomous transposon in humans. LINE-1 transposition may cause deleterious effects on the structure and function of the host cell genomes, thus causing serious genetic disease. We are interested in studying defense strategies of host cells in restricting LINE-1 mobilization, as well as the relationship between the LINE-1 retrotransposition and tumorigenesis. So far, Dr. Li has successively directed or participated in many scientific research projects including the National Natural Science Foundation of China, the National Mega-Project for Infectious Disease, and the National Mega-Project for Significant New Drug Discovery and so on.

Selected Publications

1. Cui X, Zhou R, Huang C, Zhang R, Wang J, Zhang Y, Ding J, Li X, Zhou J, Cen S. Identification of Theaflavin-3,3'-Digallate as a Novel Zika Virus Protease Inhibitor. Front Pharmacol. 2020 Oct 21;11:514313. doi: 10.3389/fphar.2020.514313. eCollection 2020.

2. Liu Y, Wu M, WangT, Xie Y, Cui X, He L, He Y, Li X, Liu M, Hu L, Cen S, Zhou J. Structural Based Screening of Antiandrogen Targeting Activation Function-2 Binding Site. Front Pharmacol. 2018 Nov 30;9:1419. doi: 10.3389/fphar.2018.01419. eCollection 2018.

3. Xie Y, Ding J, Cui X, Wu M, Huang C, Zhang R, Wang J, Li X, Cen S, Zhou J. Screening of kinase inhibitors downregulating PD-L1 expression via on/in cell quantitative immunoblots. Eur J Pharm Sci. 2019 Oct 15:105088. doi: 10.1016/j.ejps.2019.105088.

4. Wu M, Xie Y, Cui X, Huang C, Zhang R, He Y, Li X, Liu M, Cen S, Zhou J. Rational drug design for androgen receptor and glucocorticoids receptor dual antagonist.Eur J Med Chem. 2019 Mar 15;166:232-242. doi: 10.1016/j.ejmech.2019.01.036.

5. Wang J, Zhang Y, Li Q, Zhao J, Yi D, Ding J, Zhao F, Hu S, Zhou J, Deng T, Li X*, Guo F, Liang C, Cen S. Influenza Virus Exploits an Interferon-Independent lncRNA to Preserve Viral RNA Synthesis through Stabilizing Viral RNA Polymerase PB1. Cell Rep. 2019 Jun 11;27(11):3295-3304.e4. doi: 10.1016/j.celrep.2019.05.036.

6. Ding J, Ma L, Zhao J, Xie Y, Zhou J, Li X* Cen S. An integrative genomic analysis of transcriptional profiles identifies characteristic genes and patterns in HIV-infected long-term non-progressors and elite controllers. J Transl Med. 2019 Jan 21;17(1):35. doi: 10.1186/s12967-019-1777-7.

7. Yi DR, An N, Liu ZL, Xu FW, Raniga K, Li QJ, Zhou R, Wang J, Zhang YX, Zhou JM, Zhang LL, An J, Qin CF, Guo F, Li XY, Liang C, Cen S. Human MxB inhibits the replication of HCV. J Virol. 2018 Dec 10;93(1). pii: e01285-18. doi: 10.1128/JVI.01285-18.

8. Li Q, Ma L, Yi D, Wang H, Wang J, Zhang Y, Guo Y, Li X, Zhou J, Shi Y, Gao GF, Cen S.Novel cyclo-peptides inhibit Ebola pseudotyped virus entry by targeting primed GP protein.Antiviral Res. 2018 Jul;155:1-11. doi: 10.1016/j.antiviral.2018.04.020. Epub 2018 Apr 27.

9. Ding J, Zhao J, Zhou J, Li X, Wu Y, Ge M, Cen S. Association of gene polymorphism of SDF1(CXCR12) with susceptibility to HIV-1 infection and AIDS disease progression: A meta-analysis. PLoS One. 2018 Feb 8;13(2):e0191930. doi: 10.1371/journal.pone.0191930. eCollection 2018.

10. Ma L, Zhang Z, Liu Z, Pan Q, Wang J, Li X*, Guo F, Liang C, Hu L, Zhou J, Cen S. Identification of small molecule compounds targeting the interaction of HIV-1 Vif and human APOBEC3G by virtual screening and biological evaluation. Sci Rep. 2018 May 23;8(1):8067. doi: 10.1038/s41598-018-26318-3.

11. Wang J, Wang Y, Zhou R, Zhao J, Zhang Y, Yi D, Li Q, Zhou J, Guo F, Liang C, Li X, Cen S. Host Long Noncoding RNA lncRNA-PAAN Regulates the Replication of Influenza A Virus. Viruses. 2018 Jun 16;10(6). pii: E330. doi: 10.3390/v10060330.

12. Zhang YX, Huang YM, Li QJ, Li XY, Zhou YD, Guo F, Zhou JM, Cen S. A highly conserved amino acid in VP1 regulates maturation of enterovirus 71. PLoS Pathog. 2017 Sep 22;13(9):e1006625. doi: 10.1371/journal.ppat.1006625. eCollection 2017 Sep.

13. Zhai C, Ma L, Zhang Z, Ding J, Wang J, Zhang Y1, Li X, Guo F, Yu L, Zhou J, Cen S. Identification and characterization of loop7 motif and its role in regulating biological function of human APOBEC3G through molecular modeling and biological assay.Acta Pharm Sin B. 2017 Sep;7(5):571-582. doi: 10.1016/j.apsb.2017.05.002. Epub 2017 Jun 2.

14. Ding J, Zhao J, Yang Z, Ma L, Mi Z, Wu Y, Guo J, Zhou J, Li X, Guo Y, Peng Z, Wei T, Yu H, Zhang L, Ge M, Cen S. Microbial Natural Product Alternariol 5-O-Methyl Ether Inhibits HIV-1 Integration by Blocking Nuclear Import of the Pre-Integration Complex.Viruses. 2017 May 10;9(5). pii: E105. doi: 10.3390/v9050105.

15. He Y, Wu M, Liu Y, Li Q, Li X, Hu L, Cen S, Zhou J. Identification of Triptophenolide from Tripterygium wilfordii as a Pan-antagonist of Androgen Receptor. ACS Med Chem Lett. 2016 Sep 28;7(12):1024-1027. eCollection 2016.

16. Li Q, Fan S, Li X, Jin Y, He W, Zhou J, Cen S, Yang Z. Insights into the Phosphoryl Transfer Mechanism of Human Ubiquitous Mitochondrial Creatine Kinase. Sci Rep. 2016 Dec 2; 6:38088.

17. Q Zhang, Z Mi, Y Huang, L Ma, J Ding, J Wang, Y Zhang, J Zhou, F Guo, X Li*, S Cen*. 2-thio-6-azauridine Inhibits Vpu Mediated BST-2 Degradation. Retrovirology. 2016 Mar 2;13(1):13. doi: 10.1186/s12977-016-0247-z.