Microbial and Biochemical Pharmacy
CHEN Minghua
Natural Medicinal Chemistry—Bioactive compounds from terrestrial microorganisms and Traditional Chinese Medicine
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time：2021-11-15
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Name：CHEN Minghua
Department：National Laboratory for Screening New Microbial Drugs
Tel: (8610)83162728
Email: chenminghua@imb.pumc.edu.cn
Education & Research Experience
Research Experience
2016/9 – Now Associate Professor, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College
2012/9-2016/9 Research Associate, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College
Education
2009/09 – 2012/07 Ph.D., Medicinal Chemistry, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College
2006/09 – 2009/07 M.Sc., Natural Medicinal Chemistry, Traditional Chinese Pharmacy, China Pharmaceutical University
Research Field：
Natural Medicinal Chemistry—Bioactive compounds from terrestrial microorganisms and Traditional Chinese Medicine.
Research Interests：
Natural Products Discovery: Our research focus on the discovery and development of new medicinally valuable lead compounds from terrestrial microorganisms, including lichen and traditional Chinese medicine endophytes fungi, and marine derived microorganisms. The identification of new antitumor biotics and antivirus compounds are the major focus of our research.
Selected Publications
Dongsheng Li,# Chao Liu,# Xinhai Jiang, Yuan Lin, Jing Zhang, Yan Li, Xuefu You,Wei Jiang, Minghua Chen,* Yanni Xu,* Shuyi Si.* Design, synthesis, and evaluation of substituted 2-acylamide-1,3-benzo[d]zole analogues as agents against MDR- and XDR-MTB. Eur J Med Chem. 2021, 209: 112898.
1. Jiao Li,# Minghua Chen,# Xiaomeng Hao,# Shasha Li, Fang Li, Liyan Yu, Chunling Xiao, Maoluo Gan.* Structural revision and absolute configuration of burnettramic acid A. Org. Lett. 2020, 22: 98-101.
2. Minghua Chen,# Renzhong Wang,# Wuli Zhao, Liyan Yu, Conghui Zhang, Shanshan Chang, Yan Li, Tao Zhang, Jianguo Xing, Maoluo Gan,* Feng Feng,* Shuyi Si.* Isocoumarindole A, a chlorinated isocoumarin and indole alkaloid hybrid metabolite from an endolichenic fungus Aspergillus sp. Org. Lett. 2019, 21:1530-1533.
3. Jiao Li,# Yuanyuan Hu,# Xiaomeng Hao, Jiali Tan, Fang Li, Xinran Qiao, Shuzhen Chen, Chunling Xiao, Minghua Chen,* Zonggen Peng,* Maoluo Gan.* Raistrickindole A, an anti-HCV oxazinoindole alkaloid from Penicillium raistrickii IMB17-034. J. Nat. Prod. 2019, 82: 1391-1395.
4. Fang Wang,# Wuli Zhao,# Conghui Zhang, Shanshan Chang, Rongguang Shao, Jianguo Xing, Minghua Chen,* Yixuan Zhang,* Shuyi Si.* Cytotoxic metabolites from the endophytic fungus Chaetomium globosum 7951. RSC Adv., 2019, 9: 16035.
5. Qin-Mei Zhou,# Ming-Hua Chen,# Xiao-Hong Li, Cheng Peng,* Da-Sheng Lin, Xiao-Nian Li, Yang He, Liang Xiong.* Absolute configurations and bioactivities of guaiane-type sesquiterpenoids isolated from Pogostemon cablin. J. Nat. Prod. 2018, 81: 1919-1927.
6. Ling-Yan Wang,# Ming-Hua Chen,# Jiang Wu, Hua Sun, Wei Liu, Yu-Hong Qu, Yan-Cheng Li, Yu-Zhuo Wu, Rui Li, Dan Zhang, Su-Juan Wang, Sheng Lin.* Bioactive glycosides from the twigs of Litsea cubeba. J. Nat. Prod. 2017, 80: 1808-1818.
7. Ming-Hua Chen,# Shan-Shan Chang,# Biao Dong, Li-Yan Yu, Ye-Xiang Wu, Ren-Zhong Wang, Wei Jiang, Zeng-Ping Gao,* Shu-Yi Si.* Ahmpatinin iBu, a new HIV-1 protease inhibitor, from Streptomyces sp. CPCC 202950, RSC Adv., 2018, 8: 5138-5144.
8. An-Qi Lu,# Ming-Hua Chen,# Jie Gao, Lu Wang, Han-Yu Yang, Lan Li, Bo Zhang, Hao-Ke He, Su-Juan Wang.* A tri-O-bridged Diels-Alder adduct from Cortex Mori radicis, Molecules, 2018, 23(1): 133.
9. Peng-Yu Zhuang#, Ming-Hua Chen#, Ya-Nan Wang, Xiao-Xia Wang, Ya-Jing Feng, Dan-Yang Zhang, Neolignan and phenylpropanoid compounds from the fruits of Illicium simonsii Maxim, Nat. Prod. Res., 2018, 32(20): 2468-2475.
10. Chengbo Xu#, Yijing Xin#, Minghua Chen, Mingyu Ba, Qinglan Guo, Chenggen Zhu, Ying Guo#, Jiangong Shi#. Discovery, synthesis, and optimization of an N-alkoxy indolylacetamide against HIV-1 carrying NNRTI-resistant mutations from the Isatis indigotica root. Eur J Med. Chem. 2020, 189: 112071.
11. Qinglan Guo, Chengbo Xu, Minghua Chen, Sheng Lin, Yuhuan Li, Chenggen Zhu, Jiandong Jiang, Yongchun Yang, Jiangong Shi.* Sulfur-enriched alkaloids from the root of Isatis indigotica. Acta Pharm Sin B. 2018, 8(6): 933-943.
12. Yu Liu,# Fei Liu,# Ming-Ming Qiao, Li Guo, Ming-Hua Chen, Cheng Peng,* Liang Xiong.* Curcumanes A and B, two bicyclic sesquiterpenoids with significant vasorelaxant activity from Curcuma longa. Org. Lett. 2019, 21(4): 1197-1201.
13. Bin Liu,# Jiao Li,# Minghua Chen, Xiaomeng Hao, Fei Cao, Yi Tan, Yuhui Ping, Yiguang Wang, Chunling Xiao, Maoluo Gan*, Seco-tetracenomycins from the marine-derived actinomycete Saccharothrix sp. 10-10. Mar Drugs. 2018, 16(10): 345.
14. Jing Jin, Xiaoyan Yang, Tan Liu, Hua Xiao, Guiyang Wang, Mengjie Zhou, Fawang Liu, Yingtao Zhang, Dong Liu, Minghua Chen, Wei Cheng, Donghui Yang*, Ming Ma*. Fluostatins M–Q featuring a 6-5-6-6 ring skeleton and high oxidized A-rings from marine Streptomyces sp. PKU-MA00045. Mar Drugs. 2018, 16(3): 87.
15. Jian Xu, Yun-Wei Hu, Wei Qu, Ming-Hua Chen, Liang-Sheng Zhou, Qi-Rui Bia, Jian-Guang Luo, Wen-Yuan Liu, Feng Feng,* Jie Zhang.* Cytotoxic and neuroprotective activities of constituents from Alternaria alternate, a fungal endophyte of Psidium littorale. Bioorg Chem. 2019, 90:103046.
16. Jimei Liu,# Xiaona Jia,# Jinlian Zhao, Jiamin Feng, Minghua Chen, Ridao Chen, Kebo Xie, Dawei Chen, Yan Li, Dan Zhang, Ying Peng, Shuyi Si, Jungui Dai.* Bistachybotrysins L–V, bioactive phenylspirodrimane dimers from the fungus Stachybotrys chartarum. Org. Chem. Front., 2020, 7: 531-542.
